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Interleukine-1beta and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization.
J Neuroimmunol. 2005 Jan; 158(1-2):14-25.JN

Abstract

MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces diminution of the dopamine in nigrostriatal pathway and cognitive deficits in mice. MPTP treatment also increases pro-inflammatory cytokine production in substantia nigra and striatum. Since, pro-inflammatory cytokines influence striatal dopamine content and provoke cognitive impairments, the cognitive defects induced by MPTP may be partly due to brain cytokine induction in other structures than nigrostriatal pathway. Furthermore, behavioral lateralization, as assessed by paw preference, influences cytokine production at the periphery and in the central nervous system. Behavioral lateralization may thus influence brain cytokine levels after MPTP. In order to address these issues, mice selected for paw preference were injected with 25 mg/kg MPTP i.p. for five consecutive days after which striatal dopamine and DOPAC contents were measured by HPLC and IL-1beta and IL-6 quantified by ELISA in the striatum, cerebral cortex, hippocampus and hypothalamus. The results showed that MPTP treatment induced dramatic loss of DA in striatum, simultaneously, IL-6 levels decreased in the striatum and increased in hippocampus and hypothalamus, while IL-1beta levels decreased in the striatum, cerebral cortex and hippocampus. Interestingly, striatal dopamine turnover under basal conditions as well as striatal IL-1beta and IL-6 levels under basal conditions and after MPTP depended on behavioral lateralization. Left pawed mice showed a higher decrease in dopamine turnover and lower cytokine levels as compared to right pawed animals. Behavioral lateralization also influenced IL-6 hippocampal levels under basal conditions and IL-1beta cortical levels after MPTP. From these results, it can be concluded that MPTP-induced cognitive defects are accompanied by an alteration of pro-inflammatory cytokine levels in brain structures other than those involved in the nigrostriatal pathway. In addition, MPTP-induced dopamine decrease is influenced by behavioral lateralization, possibly through an effect on brain cytokine levels.

Authors+Show Affiliations

Department of Microbiology and Immunology, Shantou University Medical College, 12 Raoping Road, Shantou, Guangdong 515031, P.R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15589033

Citation

Shen, Yan-Qin, et al. "Interleukine-1beta and Interleukine-6 Levels in Striatum and Other Brain Structures After MPTP Treatment: Influence of Behavioral Lateralization." Journal of Neuroimmunology, vol. 158, no. 1-2, 2005, pp. 14-25.
Shen YQ, Hebert G, Lin LY, et al. Interleukine-1beta and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization. J Neuroimmunol. 2005;158(1-2):14-25.
Shen, Y. Q., Hebert, G., Lin, L. Y., Luo, Y. L., Moze, E., Li, K. S., & Neveu, P. J. (2005). Interleukine-1beta and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization. Journal of Neuroimmunology, 158(1-2), 14-25.
Shen YQ, et al. Interleukine-1beta and Interleukine-6 Levels in Striatum and Other Brain Structures After MPTP Treatment: Influence of Behavioral Lateralization. J Neuroimmunol. 2005;158(1-2):14-25. PubMed PMID: 15589033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukine-1beta and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization. AU - Shen,Yan-Qin, AU - Hebert,Guillaum, AU - Lin,Ling-Yun, AU - Luo,Yan-Ling, AU - Moze,Elizabeth, AU - Li,Kang-Sheng, AU - Neveu,Pierre J, PY - 2004/03/03/received PY - 2004/05/27/revised PY - 2004/06/24/accepted PY - 2004/12/14/pubmed PY - 2005/3/8/medline PY - 2004/12/14/entrez SP - 14 EP - 25 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 158 IS - 1-2 N2 - MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces diminution of the dopamine in nigrostriatal pathway and cognitive deficits in mice. MPTP treatment also increases pro-inflammatory cytokine production in substantia nigra and striatum. Since, pro-inflammatory cytokines influence striatal dopamine content and provoke cognitive impairments, the cognitive defects induced by MPTP may be partly due to brain cytokine induction in other structures than nigrostriatal pathway. Furthermore, behavioral lateralization, as assessed by paw preference, influences cytokine production at the periphery and in the central nervous system. Behavioral lateralization may thus influence brain cytokine levels after MPTP. In order to address these issues, mice selected for paw preference were injected with 25 mg/kg MPTP i.p. for five consecutive days after which striatal dopamine and DOPAC contents were measured by HPLC and IL-1beta and IL-6 quantified by ELISA in the striatum, cerebral cortex, hippocampus and hypothalamus. The results showed that MPTP treatment induced dramatic loss of DA in striatum, simultaneously, IL-6 levels decreased in the striatum and increased in hippocampus and hypothalamus, while IL-1beta levels decreased in the striatum, cerebral cortex and hippocampus. Interestingly, striatal dopamine turnover under basal conditions as well as striatal IL-1beta and IL-6 levels under basal conditions and after MPTP depended on behavioral lateralization. Left pawed mice showed a higher decrease in dopamine turnover and lower cytokine levels as compared to right pawed animals. Behavioral lateralization also influenced IL-6 hippocampal levels under basal conditions and IL-1beta cortical levels after MPTP. From these results, it can be concluded that MPTP-induced cognitive defects are accompanied by an alteration of pro-inflammatory cytokine levels in brain structures other than those involved in the nigrostriatal pathway. In addition, MPTP-induced dopamine decrease is influenced by behavioral lateralization, possibly through an effect on brain cytokine levels. SN - 0165-5728 UR - https://www.unboundmedicine.com/medline/citation/15589033/Interleukine_1beta_and_interleukine_6_levels_in_striatum_and_other_brain_structures_after_MPTP_treatment:_influence_of_behavioral_lateralization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(04)00208-5 DB - PRIME DP - Unbound Medicine ER -