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Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women.

Abstract

The relationship between MTHFR (C677T) genotypes of the methylenetetrahydrofolate reductase, bone mineral density (BMD), and vertebral fracture was studied in 657 Chinese men and women. No association between MTHFR (C677T) and BMD was found in postmenopausal women (aged 55-59 years, n=178), elderly women (aged 70-79 years, n=247), or elderly men (aged 70-79 years, n=232) at the hip, spine, or total body (P >0.05 by ANCOVA). In all study groups, there was no effect of an interaction between MTHFR (C677T) and daily dietary calcium intake on BMD (P >0.05 for the interaction effects by two-way ANCOVA). No statistically significant association was observed between MTHFR (C677T) genotypes and vertebral fracture. The MTHFR (C677T) genotypes for CC, CT, and TT among elderly women with or without vertebral fracture were 5%, 33%, 62%; 6%, 37%, and 57%, respectively, and those for elderly men with and without vertebral fracture were 9%, 31%, 60%; 5%, 35%, and 60%, respectively. The prevalence of TT in our study group was 5% compared to 8% in the Danish or 18.6% in the Japanese. We found no association between MTHFR (C677T) and BMD of Chinese men or women. It would be interesting to study the interactions with folate, B12, and homocysteine.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. Martinli@cuhk.edu.hk

    ,

    Source

    Bone 35:6 2004 Dec pg 1369-74

    MeSH

    Aged
    Asian Continental Ancestry Group
    Bone Density
    Cytosine
    Female
    Genotype
    Humans
    Male
    Methylenetetrahydrofolate Reductase (NADPH2)
    Middle Aged
    Polymorphism, Genetic
    Thymine

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    15589218

    Citation

    Li, M, et al. "Methylenetetrahydrofolate Reductase Polymorphism (MTHFR C677T) and Bone Mineral Density in Chinese Men and Women." Bone, vol. 35, no. 6, 2004, pp. 1369-74.
    Li M, Lau EM, Woo J. Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women. Bone. 2004;35(6):1369-74.
    Li, M., Lau, E. M., & Woo, J. (2004). Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women. Bone, 35(6), pp. 1369-74.
    Li M, Lau EM, Woo J. Methylenetetrahydrofolate Reductase Polymorphism (MTHFR C677T) and Bone Mineral Density in Chinese Men and Women. Bone. 2004;35(6):1369-74. PubMed PMID: 15589218.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women. AU - Li,M, AU - Lau,E M C, AU - Woo,J, PY - 2004/05/27/received PY - 2004/09/16/revised PY - 2004/09/20/accepted PY - 2004/12/14/pubmed PY - 2005/5/20/medline PY - 2004/12/14/entrez SP - 1369 EP - 74 JF - Bone JO - Bone VL - 35 IS - 6 N2 - The relationship between MTHFR (C677T) genotypes of the methylenetetrahydrofolate reductase, bone mineral density (BMD), and vertebral fracture was studied in 657 Chinese men and women. No association between MTHFR (C677T) and BMD was found in postmenopausal women (aged 55-59 years, n=178), elderly women (aged 70-79 years, n=247), or elderly men (aged 70-79 years, n=232) at the hip, spine, or total body (P >0.05 by ANCOVA). In all study groups, there was no effect of an interaction between MTHFR (C677T) and daily dietary calcium intake on BMD (P >0.05 for the interaction effects by two-way ANCOVA). No statistically significant association was observed between MTHFR (C677T) genotypes and vertebral fracture. The MTHFR (C677T) genotypes for CC, CT, and TT among elderly women with or without vertebral fracture were 5%, 33%, 62%; 6%, 37%, and 57%, respectively, and those for elderly men with and without vertebral fracture were 9%, 31%, 60%; 5%, 35%, and 60%, respectively. The prevalence of TT in our study group was 5% compared to 8% in the Danish or 18.6% in the Japanese. We found no association between MTHFR (C677T) and BMD of Chinese men or women. It would be interesting to study the interactions with folate, B12, and homocysteine. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/15589218/Methylenetetrahydrofolate_reductase_polymorphism__MTHFR_C677T__and_bone_mineral_density_in_Chinese_men_and_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(04)00372-2 DB - PRIME DP - Unbound Medicine ER -