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5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat.
Eur Neuropsychopharmacol. 2004 Dec; 14(6):487-95.EN

Abstract

Fluoxetine, a selective serotonin reuptake inhibitor, shows moderate efficacy and potency in the rat forced swimming depression test and the shock-induced ultrasonic vocalization anxiety test, whereas the 5-HT(1A) receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is highly efficient and potent in both models. Whereas the 5-HT(1A) receptor antagonist WAY 100,635 abolishes the effect of 8-OH-DPAT in both models, it only attenuates the antidepressant-like effect of fluoxetine. Pretreatment with the 5-HT-depleting agent parachlorophenylalanine attenuates the antidepressant-like effect of fluoxetine, but not that of 8-OH-DPAT. This suggests that the antidepressant-like effect of fluoxetine and 8-OH-DPAT results from indirect (via increased synaptic availability of 5-HT) and direct stimulation of postsynaptic 5-HT(1A) receptors, respectively; whereas the anxiolytic-like effect of fluoxetine is not mediated by 5-HT(1A) receptors. The data support the hypothesis that the antidepressant- and anxiolytic-like effect of 8-OH-DPAT is predominantly mediated by post- and presynaptic 5-HT(1A) receptors, respectively, and that 5-HT(1A) receptors are only partially involved in the antidepressant-like effect of fluoxetine.

Authors+Show Affiliations

CNS Research, Bayer HealthCare, Aprather Weg 18a, 42096 Wuppertal, Germany. Jean.DeVry@Grunenthal.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15589388

Citation

De Vry, J, et al. "5-HT1A Receptors Are Differentially Involved in the Anxiolytic- and Antidepressant-like Effects of 8-OH-DPAT and Fluoxetine in the Rat." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 14, no. 6, 2004, pp. 487-95.
De Vry J, Schreiber R, Melon C, et al. 5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat. Eur Neuropsychopharmacol. 2004;14(6):487-95.
De Vry, J., Schreiber, R., Melon, C., Dalmus, M., & Jentzsch, K. R. (2004). 5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 14(6), 487-95.
De Vry J, et al. 5-HT1A Receptors Are Differentially Involved in the Anxiolytic- and Antidepressant-like Effects of 8-OH-DPAT and Fluoxetine in the Rat. Eur Neuropsychopharmacol. 2004;14(6):487-95. PubMed PMID: 15589388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat. AU - De Vry,J, AU - Schreiber,R, AU - Melon,C, AU - Dalmus,M, AU - Jentzsch,K R, PY - 2003/10/21/received PY - 2004/01/06/revised PY - 2004/01/09/accepted PY - 2004/12/14/pubmed PY - 2005/1/14/medline PY - 2004/12/14/entrez SP - 487 EP - 95 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 14 IS - 6 N2 - Fluoxetine, a selective serotonin reuptake inhibitor, shows moderate efficacy and potency in the rat forced swimming depression test and the shock-induced ultrasonic vocalization anxiety test, whereas the 5-HT(1A) receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is highly efficient and potent in both models. Whereas the 5-HT(1A) receptor antagonist WAY 100,635 abolishes the effect of 8-OH-DPAT in both models, it only attenuates the antidepressant-like effect of fluoxetine. Pretreatment with the 5-HT-depleting agent parachlorophenylalanine attenuates the antidepressant-like effect of fluoxetine, but not that of 8-OH-DPAT. This suggests that the antidepressant-like effect of fluoxetine and 8-OH-DPAT results from indirect (via increased synaptic availability of 5-HT) and direct stimulation of postsynaptic 5-HT(1A) receptors, respectively; whereas the anxiolytic-like effect of fluoxetine is not mediated by 5-HT(1A) receptors. The data support the hypothesis that the antidepressant- and anxiolytic-like effect of 8-OH-DPAT is predominantly mediated by post- and presynaptic 5-HT(1A) receptors, respectively, and that 5-HT(1A) receptors are only partially involved in the antidepressant-like effect of fluoxetine. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/15589388/5_HT1A_receptors_are_differentially_involved_in_the_anxiolytic__and_antidepressant_like_effects_of_8_OH_DPAT_and_fluoxetine_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924977X04000185 DB - PRIME DP - Unbound Medicine ER -