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Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy.
J Med Microbiol 2005; 54(Pt 1):83-5JM

Abstract

The objective of this study was to investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who presented with acute otitis media (AOM) or otitis media that recurred after amoxicillin therapy. Nasopharyngeal cultures obtained from 72 patients, 40 with AOM and 32 with recurrent otitis media (ROM), were analysed. Thirty-six potentially pathogenic organisms were recovered in 34 (85 %) of the children from the AOM group, and 42 were isolated from 29 (91 %) of the children from the ROM group. The organisms isolated were Streptococcus pneumoniae (n = 26), Haemophilus influenzae non-type b (n = 22), Moraxella catarrhalis (n = 13), Streptococcus pyogenes (n = 8) and Staphylococcus aureus (n = 9). Resistance to the eight antimicrobial agents used was found in 37 instances in the AOM group as compared to 99 instances in the ROM group (P < 0.005). The difference between AOM and ROM was significant with Streptococcus pneumoniae resistance to amoxicillin (P < 0.005), to amoxicillin/clavulanate (P < 0.005), to trimethoprim/sulfamethoxazole (P < 0.01), to cefixime (P < 0.01) and to azithromycin (P < 0.01), and for H. influenzae resistance to amoxicillin (P < 0.025). These data illustrate the higher recovery rate of antimicrobial-resistant Streptococcus pneumoniae and H. influenzae from the nasopharynx of children who had otitis media that recurred after amoxicillin therapy than those with AOM.

Authors+Show Affiliations

Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington DC 20016, USA. ib6@georgetown.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15591260

Citation

Brook, Itzhak, and Alan E. Gober. "Antimicrobial Resistance in the Nasopharyngeal Flora of Children With Acute Otitis Media and Otitis Media Recurring After Amoxicillin Therapy." Journal of Medical Microbiology, vol. 54, no. Pt 1, 2005, pp. 83-5.
Brook I, Gober AE. Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy. J Med Microbiol. 2005;54(Pt 1):83-5.
Brook, I., & Gober, A. E. (2005). Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy. Journal of Medical Microbiology, 54(Pt 1), pp. 83-5.
Brook I, Gober AE. Antimicrobial Resistance in the Nasopharyngeal Flora of Children With Acute Otitis Media and Otitis Media Recurring After Amoxicillin Therapy. J Med Microbiol. 2005;54(Pt 1):83-5. PubMed PMID: 15591260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy. AU - Brook,Itzhak, AU - Gober,Alan E, PY - 2004/12/14/pubmed PY - 2005/2/12/medline PY - 2004/12/14/entrez SP - 83 EP - 5 JF - Journal of medical microbiology JO - J. Med. Microbiol. VL - 54 IS - Pt 1 N2 - The objective of this study was to investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who presented with acute otitis media (AOM) or otitis media that recurred after amoxicillin therapy. Nasopharyngeal cultures obtained from 72 patients, 40 with AOM and 32 with recurrent otitis media (ROM), were analysed. Thirty-six potentially pathogenic organisms were recovered in 34 (85 %) of the children from the AOM group, and 42 were isolated from 29 (91 %) of the children from the ROM group. The organisms isolated were Streptococcus pneumoniae (n = 26), Haemophilus influenzae non-type b (n = 22), Moraxella catarrhalis (n = 13), Streptococcus pyogenes (n = 8) and Staphylococcus aureus (n = 9). Resistance to the eight antimicrobial agents used was found in 37 instances in the AOM group as compared to 99 instances in the ROM group (P < 0.005). The difference between AOM and ROM was significant with Streptococcus pneumoniae resistance to amoxicillin (P < 0.005), to amoxicillin/clavulanate (P < 0.005), to trimethoprim/sulfamethoxazole (P < 0.01), to cefixime (P < 0.01) and to azithromycin (P < 0.01), and for H. influenzae resistance to amoxicillin (P < 0.025). These data illustrate the higher recovery rate of antimicrobial-resistant Streptococcus pneumoniae and H. influenzae from the nasopharynx of children who had otitis media that recurred after amoxicillin therapy than those with AOM. SN - 0022-2615 UR - https://www.unboundmedicine.com/medline/citation/15591260/Antimicrobial_resistance_in_the_nasopharyngeal_flora_of_children_with_acute_otitis_media_and_otitis_media_recurring_after_amoxicillin_therapy_ L2 - http://jmm.microbiologyresearch.org/pubmed/content/journal/jmm/10.1099/jmm.0.45819-0 DB - PRIME DP - Unbound Medicine ER -