Tags

Type your tag names separated by a space and hit enter

A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy.
Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17843-8.PN

Abstract

Recently, MHC class I molecules have been shown to be important for the retraction of synaptic connections that normally occurs during development [Huh, G.S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M. & Shatz, C. J. (2000) Science 290, 2155-2158]. In the adult CNS, a classical response of neurons to axon lesion is the detachment of synapses from the cell body and dendrites. We have investigated whether MHC I molecules are involved also in this type of synaptic detachment by studying the synaptic input to sciatic motoneurons at 1 week after peripheral nerve transection in beta2-microglobulin or transporter associated with antigen processing 1-null mutant mice, in which cell surface MHC I expression is impaired. Surprisingly, lesioned motoneurons in mutant mice showed more extensive synaptic detachments than those in wild-type animals. This surplus removal of synapses was entirely directed toward inhibitory synapses assembled in clusters. In parallel, a significantly smaller population of motoneurons reinnervated the distal stump of the transected sciatic nerve in mutants. MHC I molecules, which traditionally have been linked with immunological mechanisms, are thus crucial for a selective maintenance of synapses during the synaptic removal process in neurons after lesion, and the lack of MHC I expression may impede the ability of neurons to regenerate axons.

Authors+Show Affiliations

Department of Neuroscience and Department of Microbiology, Tumor Biology Center, and Strategic Research Center IRIS, Karolinska Institutet, SE-171 77 Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15591351

Citation

Oliveira, Alexandre L R., et al. "A Role for MHC Class I Molecules in Synaptic Plasticity and Regeneration of Neurons After Axotomy." Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 51, 2004, pp. 17843-8.
Oliveira AL, Thams S, Lidman O, et al. A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. Proc Natl Acad Sci USA. 2004;101(51):17843-8.
Oliveira, A. L., Thams, S., Lidman, O., Piehl, F., Hökfelt, T., Kärre, K., Lindå, H., & Cullheim, S. (2004). A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. Proceedings of the National Academy of Sciences of the United States of America, 101(51), 17843-8.
Oliveira AL, et al. A Role for MHC Class I Molecules in Synaptic Plasticity and Regeneration of Neurons After Axotomy. Proc Natl Acad Sci USA. 2004 Dec 21;101(51):17843-8. PubMed PMID: 15591351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. AU - Oliveira,Alexandre L R, AU - Thams,Sebastian, AU - Lidman,Olle, AU - Piehl,Fredrik, AU - Hökfelt,Tomas, AU - Kärre,Klas, AU - Lindå,Hans, AU - Cullheim,Staffan, Y1 - 2004/12/10/ PY - 2004/12/14/pubmed PY - 2005/2/5/medline PY - 2004/12/14/entrez SP - 17843 EP - 8 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 101 IS - 51 N2 - Recently, MHC class I molecules have been shown to be important for the retraction of synaptic connections that normally occurs during development [Huh, G.S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M. & Shatz, C. J. (2000) Science 290, 2155-2158]. In the adult CNS, a classical response of neurons to axon lesion is the detachment of synapses from the cell body and dendrites. We have investigated whether MHC I molecules are involved also in this type of synaptic detachment by studying the synaptic input to sciatic motoneurons at 1 week after peripheral nerve transection in beta2-microglobulin or transporter associated with antigen processing 1-null mutant mice, in which cell surface MHC I expression is impaired. Surprisingly, lesioned motoneurons in mutant mice showed more extensive synaptic detachments than those in wild-type animals. This surplus removal of synapses was entirely directed toward inhibitory synapses assembled in clusters. In parallel, a significantly smaller population of motoneurons reinnervated the distal stump of the transected sciatic nerve in mutants. MHC I molecules, which traditionally have been linked with immunological mechanisms, are thus crucial for a selective maintenance of synapses during the synaptic removal process in neurons after lesion, and the lack of MHC I expression may impede the ability of neurons to regenerate axons. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/15591351/A_role_for_MHC_class_I_molecules_in_synaptic_plasticity_and_regeneration_of_neurons_after_axotomy_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=15591351 DB - PRIME DP - Unbound Medicine ER -