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Perinatal outcomes in severe preeclampsia-eclampsia with and without HELLP syndrome.
Gynecol Obstet Invest. 2005; 59(2):113-8.GO

Abstract

OBJECTIVE

Our purpose was to find out and compare perinatal outcomes in pregnancies complicated by severe preeclampsia-eclampsia with and without HELLP syndrome.

METHODS

Clinical and laboratory findings, and perinatal-neonatal outcomes of all pregnants with severe preeclampsia, eclampsia and HELLP have been prospectively recorded. Results were compared by means of Student's t test, chi2 analysis and Fisher's exact test as appropriate.

RESULTS

Among 367 consecutive severe preeclampsia, 106 (29%) had HELLP syndrome, 261 (71%) had severe preeclampsia and eclampsia. Mean gestational age and birth weight at delivery in severe preeclampsia without HELLP syndrome and in HELLP syndrome were 34.1 +/- 6.1 vs. 33.0 +/- 5.8 weeks (p = 0.119) and 1,886 +/- 764 vs. 1,724 +/- 776 g (p = 0.063), respectively. Comparing overall fetal mortality (4.6 vs. 10.3%, p = 0.009) and perinatal mortality (8.0% vs. 16.8%, p = 0.026) in severe preeclampsia-eclampsia and HELLP syndrome, respectively, there were statistically significant differences. But when analyses were performed according to gestational age before and after 32nd gestational week, the difference of perinatal mortality between the two groups was non-significant (p = 0.644 and p = 0.250), suggesting borderline difference. The most common contributing factor for fetal death after 32nd week was due to abruptio placenta without prenatal follow-up. Neonatal morbidity and neonatal mortality (4.8 vs. 6.3%, p = 0.905) in severe preeclampsia-eclampsia and HELLP syndrome respectively were similar and the difference was statistically nonsignificant.

CONCLUSIONS

Perinatal mortality and neonatal morbidity-mortality according to gestational age before and after the 32nd week were similar in HELLP syndrome compared with severe preeclampsia-eclampsia without HELLP but overall fetal mortality was higher in HELLP syndrome with no regular prenatal care.

Authors+Show Affiliations

Maternal and Fetal Unit, Istanbul SSK Bakirkoy Women and Children Hospital, Istanbul, Turkey. ahmetgul@ttnet.net.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15591806

Citation

Gul, Ahmet, et al. "Perinatal Outcomes in Severe Preeclampsia-eclampsia With and Without HELLP Syndrome." Gynecologic and Obstetric Investigation, vol. 59, no. 2, 2005, pp. 113-8.
Gul A, Cebeci A, Aslan H, et al. Perinatal outcomes in severe preeclampsia-eclampsia with and without HELLP syndrome. Gynecol Obstet Invest. 2005;59(2):113-8.
Gul, A., Cebeci, A., Aslan, H., Polat, I., Ozdemir, A., & Ceylan, Y. (2005). Perinatal outcomes in severe preeclampsia-eclampsia with and without HELLP syndrome. Gynecologic and Obstetric Investigation, 59(2), 113-8.
Gul A, et al. Perinatal Outcomes in Severe Preeclampsia-eclampsia With and Without HELLP Syndrome. Gynecol Obstet Invest. 2005;59(2):113-8. PubMed PMID: 15591806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal outcomes in severe preeclampsia-eclampsia with and without HELLP syndrome. AU - Gul,Ahmet, AU - Cebeci,Altan, AU - Aslan,Halil, AU - Polat,Ibrahim, AU - Ozdemir,Aykut, AU - Ceylan,Yavuz, Y1 - 2004/12/09/ PY - 2004/02/25/received PY - 2004/10/09/accepted PY - 2004/12/14/pubmed PY - 2005/5/27/medline PY - 2004/12/14/entrez SP - 113 EP - 8 JF - Gynecologic and obstetric investigation JO - Gynecol Obstet Invest VL - 59 IS - 2 N2 - OBJECTIVE: Our purpose was to find out and compare perinatal outcomes in pregnancies complicated by severe preeclampsia-eclampsia with and without HELLP syndrome. METHODS: Clinical and laboratory findings, and perinatal-neonatal outcomes of all pregnants with severe preeclampsia, eclampsia and HELLP have been prospectively recorded. Results were compared by means of Student's t test, chi2 analysis and Fisher's exact test as appropriate. RESULTS: Among 367 consecutive severe preeclampsia, 106 (29%) had HELLP syndrome, 261 (71%) had severe preeclampsia and eclampsia. Mean gestational age and birth weight at delivery in severe preeclampsia without HELLP syndrome and in HELLP syndrome were 34.1 +/- 6.1 vs. 33.0 +/- 5.8 weeks (p = 0.119) and 1,886 +/- 764 vs. 1,724 +/- 776 g (p = 0.063), respectively. Comparing overall fetal mortality (4.6 vs. 10.3%, p = 0.009) and perinatal mortality (8.0% vs. 16.8%, p = 0.026) in severe preeclampsia-eclampsia and HELLP syndrome, respectively, there were statistically significant differences. But when analyses were performed according to gestational age before and after 32nd gestational week, the difference of perinatal mortality between the two groups was non-significant (p = 0.644 and p = 0.250), suggesting borderline difference. The most common contributing factor for fetal death after 32nd week was due to abruptio placenta without prenatal follow-up. Neonatal morbidity and neonatal mortality (4.8 vs. 6.3%, p = 0.905) in severe preeclampsia-eclampsia and HELLP syndrome respectively were similar and the difference was statistically nonsignificant. CONCLUSIONS: Perinatal mortality and neonatal morbidity-mortality according to gestational age before and after the 32nd week were similar in HELLP syndrome compared with severe preeclampsia-eclampsia without HELLP but overall fetal mortality was higher in HELLP syndrome with no regular prenatal care. SN - 0378-7346 UR - https://www.unboundmedicine.com/medline/citation/15591806/Perinatal_outcomes_in_severe_preeclampsia_eclampsia_with_and_without_HELLP_syndrome_ DB - PRIME DP - Unbound Medicine ER -