Tags

Type your tag names separated by a space and hit enter

IgE reactivity pattern to timothy and birch pollen allergens in Finnish and Russian Karelia.
Int Arch Allergy Immunol. 2005 Jan; 136(1):33-8.IA

Abstract

BACKGROUND

Little is known about differences in IgE reactivity patterns to individual allergens in random populations. We studied the IgE reactivity profile to individual recombinant (r) and native (n) allergens in sera from subjects sensitized to timothy and/or birch pollen living in Finnish and Russian Karelia.

METHODS

Sera from IgE-sensitized adults were obtained from an epidemiological study on a random sample of 1,177 subjects. The IgE reactivity to pollen extracts and eight timothy (rPhl p 1, 2, 5, 6, 7, 11, 12 and nPhl p 4) and three birch pollen allergens (rBet v 1, 2 and 4) were analyzed with UniCAP.

RESULTS

The levels of IgE antibodies to timothy and birch pollen were higher in Finnish (median 5.2, range 0.35 to >100 kUA/l,) than in Russian Karelia (median 1.8 kUA/l, range 0.43-25.2 kUA/l, p <0.01). There was a significantly higher prevalence of IgE reactivity to three timothy pollen allergens in Finnish (n=57) than in Russian Karelia (n=12): rPhl p 2, 28 vs. 0%; rPhl p 5, 60 vs. 0%; rPhl p 6, 47 vs. 0%. The prevalence of IgE reactivity to the birch pollen allergens was similar in the two populations. IgE reactivity to rPhl p 2, 5, 6 and 11 was associated with hay fever symptoms. The timothy-pollen-specific serum IgE levels and the numbers of IgE reactivities to individual allergens correlated significantly (rs=0.87, p <0.0001).

CONCLUSIONS

The data indicate that timothy- and birch pollen-specific IgE levels are higher in Finnish compared to Russian Karelia. This is reflected in wider IgE reactivity to individual timothy pollen allergens in Finnish Karelia, including the major allergen Phl p 5, and increased pollen allergy.

Authors+Show Affiliations

Pharmacia Diagnostics AB and Uppsala University, Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala, Sweden. robert.moverare@diagnostics.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15591811

Citation

Movérare, Robert, et al. "IgE Reactivity Pattern to Timothy and Birch Pollen Allergens in Finnish and Russian Karelia." International Archives of Allergy and Immunology, vol. 136, no. 1, 2005, pp. 33-8.
Movérare R, Petays T, Vartiainen E, et al. IgE reactivity pattern to timothy and birch pollen allergens in Finnish and Russian Karelia. Int Arch Allergy Immunol. 2005;136(1):33-8.
Movérare, R., Petays, T., Vartiainen, E., & Haahtela, T. (2005). IgE reactivity pattern to timothy and birch pollen allergens in Finnish and Russian Karelia. International Archives of Allergy and Immunology, 136(1), 33-8.
Movérare R, et al. IgE Reactivity Pattern to Timothy and Birch Pollen Allergens in Finnish and Russian Karelia. Int Arch Allergy Immunol. 2005;136(1):33-8. PubMed PMID: 15591811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgE reactivity pattern to timothy and birch pollen allergens in Finnish and Russian Karelia. AU - Movérare,Robert, AU - Petays,Tuula, AU - Vartiainen,Erkki, AU - Haahtela,Tari, Y1 - 2004/12/08/ PY - 2003/11/26/received PY - 2004/09/24/accepted PY - 2004/12/14/pubmed PY - 2005/3/4/medline PY - 2004/12/14/entrez SP - 33 EP - 8 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 136 IS - 1 N2 - BACKGROUND: Little is known about differences in IgE reactivity patterns to individual allergens in random populations. We studied the IgE reactivity profile to individual recombinant (r) and native (n) allergens in sera from subjects sensitized to timothy and/or birch pollen living in Finnish and Russian Karelia. METHODS: Sera from IgE-sensitized adults were obtained from an epidemiological study on a random sample of 1,177 subjects. The IgE reactivity to pollen extracts and eight timothy (rPhl p 1, 2, 5, 6, 7, 11, 12 and nPhl p 4) and three birch pollen allergens (rBet v 1, 2 and 4) were analyzed with UniCAP. RESULTS: The levels of IgE antibodies to timothy and birch pollen were higher in Finnish (median 5.2, range 0.35 to >100 kUA/l,) than in Russian Karelia (median 1.8 kUA/l, range 0.43-25.2 kUA/l, p <0.01). There was a significantly higher prevalence of IgE reactivity to three timothy pollen allergens in Finnish (n=57) than in Russian Karelia (n=12): rPhl p 2, 28 vs. 0%; rPhl p 5, 60 vs. 0%; rPhl p 6, 47 vs. 0%. The prevalence of IgE reactivity to the birch pollen allergens was similar in the two populations. IgE reactivity to rPhl p 2, 5, 6 and 11 was associated with hay fever symptoms. The timothy-pollen-specific serum IgE levels and the numbers of IgE reactivities to individual allergens correlated significantly (rs=0.87, p <0.0001). CONCLUSIONS: The data indicate that timothy- and birch pollen-specific IgE levels are higher in Finnish compared to Russian Karelia. This is reflected in wider IgE reactivity to individual timothy pollen allergens in Finnish Karelia, including the major allergen Phl p 5, and increased pollen allergy. SN - 1018-2438 UR - https://www.unboundmedicine.com/medline/citation/15591811/IgE_reactivity_pattern_to_timothy_and_birch_pollen_allergens_in_Finnish_and_Russian_Karelia_ L2 - https://www.karger.com?DOI=10.1159/000082582 DB - PRIME DP - Unbound Medicine ER -