Tags

Type your tag names separated by a space and hit enter

Persistence of human papillomavirus infection as a predictor for recurrence in carcinoma of the cervix after radiotherapy.
Am J Obstet Gynecol 2004; 191(6):1907-13AJ

Abstract

OBJECTIVE

This study was undertaken to examine a possible correlation between clearance or persistence of human papillomavirus (HPV) infection and radiation response in carcinoma of the cervix.

STUDY DESIGN

We reviewed 97 patients with HPV-positive cervical squamous cell carcinoma (International Federation of Gynecology and Obstetrics [FIGO] stage IB-IVA) treated with radiotherapy. Examination of HPV DNA was performed by the polymerase chain reaction-based assay.

RESULTS

Cervical HPV DNA cleared in 42 patients (43.3%) and persisted in 55 patients (56.7%) at the end of irradiation. All of 42 HPV-cleared patients (100.0%) and 50 of 55 HPV-persistent patients (90.9%) had complete response. Of 92 patients with complete response, 20 (21.7%) had local recurrence develop. The recurrence rate was significantly higher in HPV-persisted patients (34.0%) than in HPV-cleared patients (7.1%) (P = .0016). Univariate analysis demonstrated the significant differences for both 5-year local disease-free survival (LDFS) and overall survival (OAS) between HPV-cleared and HPV-persisted groups. Multivariate analysis showed that persistence of HPV DNA was the most powerful independent predictor for LDFS and OAS compared with other prognostic factors, such as FIGO stage or node swelling.

CONCLUSION

In HPV-positive cervical carcinoma, persistence of HPV DNA in the cervix at the end of irradiation was highly predictive of LDFS and OAS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus, 207 Uehara Nishihara-Machi, Nakagami-Gun, Okinawa 903-0215, Japan. ynagai@med.u-ryukyu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15592271

Citation

Nagai, Yutaka, et al. "Persistence of Human Papillomavirus Infection as a Predictor for Recurrence in Carcinoma of the Cervix After Radiotherapy." American Journal of Obstetrics and Gynecology, vol. 191, no. 6, 2004, pp. 1907-13.
Nagai Y, Toma T, Moromizato H, et al. Persistence of human papillomavirus infection as a predictor for recurrence in carcinoma of the cervix after radiotherapy. Am J Obstet Gynecol. 2004;191(6):1907-13.
Nagai, Y., Toma, T., Moromizato, H., Maehama, T., Asato, T., Kariya, K., & Kanazawa, K. (2004). Persistence of human papillomavirus infection as a predictor for recurrence in carcinoma of the cervix after radiotherapy. American Journal of Obstetrics and Gynecology, 191(6), pp. 1907-13.
Nagai Y, et al. Persistence of Human Papillomavirus Infection as a Predictor for Recurrence in Carcinoma of the Cervix After Radiotherapy. Am J Obstet Gynecol. 2004;191(6):1907-13. PubMed PMID: 15592271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistence of human papillomavirus infection as a predictor for recurrence in carcinoma of the cervix after radiotherapy. AU - Nagai,Yutaka, AU - Toma,Takashi, AU - Moromizato,Hidehiko, AU - Maehama,Toshiyuki, AU - Asato,Tsuyoshi, AU - Kariya,Ken-Ichi, AU - Kanazawa,Koji, PY - 2004/12/14/pubmed PY - 2005/1/28/medline PY - 2004/12/14/entrez SP - 1907 EP - 13 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 191 IS - 6 N2 - OBJECTIVE: This study was undertaken to examine a possible correlation between clearance or persistence of human papillomavirus (HPV) infection and radiation response in carcinoma of the cervix. STUDY DESIGN: We reviewed 97 patients with HPV-positive cervical squamous cell carcinoma (International Federation of Gynecology and Obstetrics [FIGO] stage IB-IVA) treated with radiotherapy. Examination of HPV DNA was performed by the polymerase chain reaction-based assay. RESULTS: Cervical HPV DNA cleared in 42 patients (43.3%) and persisted in 55 patients (56.7%) at the end of irradiation. All of 42 HPV-cleared patients (100.0%) and 50 of 55 HPV-persistent patients (90.9%) had complete response. Of 92 patients with complete response, 20 (21.7%) had local recurrence develop. The recurrence rate was significantly higher in HPV-persisted patients (34.0%) than in HPV-cleared patients (7.1%) (P = .0016). Univariate analysis demonstrated the significant differences for both 5-year local disease-free survival (LDFS) and overall survival (OAS) between HPV-cleared and HPV-persisted groups. Multivariate analysis showed that persistence of HPV DNA was the most powerful independent predictor for LDFS and OAS compared with other prognostic factors, such as FIGO stage or node swelling. CONCLUSION: In HPV-positive cervical carcinoma, persistence of HPV DNA in the cervix at the end of irradiation was highly predictive of LDFS and OAS. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/15592271/Persistence_of_human_papillomavirus_infection_as_a_predictor_for_recurrence_in_carcinoma_of_the_cervix_after_radiotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937804007112 DB - PRIME DP - Unbound Medicine ER -