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Multicomponent complexes of piroxicam with cyclodextrins and hydroxypropyl methylcellulose.
Drug Dev Ind Pharm. 2004; 30(10):1051-60.DD

Abstract

The purpose of the study was to investigate the effect of hydroxypropyl methylcellulose (HPMC) on the complexation of piroxicam (PX) with beta-cyclodextrin (beta-CD) and dimethyl-beta-cyclodextrin (DM-beta-CD) in solution and in the solid state. Phase solubility study revealed a positive effect of the polymer on the drug complexation. Improvement in stability constants values, Ks, of ternary complexes clearly proves the benefit of the HPMC addition for promoting higher complexation efficiency. Solid binary and ternary complexes were prepared by spray drying. Drug-CD and drug-CD-polymer interactions were studied in the solid state by differential scanning calorimetry (DSC), zeta-potential measurements, and particle size distribution. A marked increase in the PX dissolution rate was observed even in binary and ternary complexes. The presence of HPMC in ternary complexes slightly retarded the release of PX. Cyclodextrin complexation increased the PX concentration gradient over the semipermeable membrane, resulting in an increased PX flux. The retarded diffusion of PX to the membrane interface decreased the PX flux values of the ternary complexes.

Authors+Show Affiliations

Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15595571

Citation

Jug, Mario, and Mira Bećirević-Laćan. "Multicomponent Complexes of Piroxicam With Cyclodextrins and Hydroxypropyl Methylcellulose." Drug Development and Industrial Pharmacy, vol. 30, no. 10, 2004, pp. 1051-60.
Jug M, Bećirević-Laćan M. Multicomponent complexes of piroxicam with cyclodextrins and hydroxypropyl methylcellulose. Drug Dev Ind Pharm. 2004;30(10):1051-60.
Jug, M., & Bećirević-Laćan, M. (2004). Multicomponent complexes of piroxicam with cyclodextrins and hydroxypropyl methylcellulose. Drug Development and Industrial Pharmacy, 30(10), 1051-60.
Jug M, Bećirević-Laćan M. Multicomponent Complexes of Piroxicam With Cyclodextrins and Hydroxypropyl Methylcellulose. Drug Dev Ind Pharm. 2004;30(10):1051-60. PubMed PMID: 15595571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multicomponent complexes of piroxicam with cyclodextrins and hydroxypropyl methylcellulose. AU - Jug,Mario, AU - Bećirević-Laćan,Mira, PY - 2004/12/15/pubmed PY - 2005/4/23/medline PY - 2004/12/15/entrez SP - 1051 EP - 60 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 30 IS - 10 N2 - The purpose of the study was to investigate the effect of hydroxypropyl methylcellulose (HPMC) on the complexation of piroxicam (PX) with beta-cyclodextrin (beta-CD) and dimethyl-beta-cyclodextrin (DM-beta-CD) in solution and in the solid state. Phase solubility study revealed a positive effect of the polymer on the drug complexation. Improvement in stability constants values, Ks, of ternary complexes clearly proves the benefit of the HPMC addition for promoting higher complexation efficiency. Solid binary and ternary complexes were prepared by spray drying. Drug-CD and drug-CD-polymer interactions were studied in the solid state by differential scanning calorimetry (DSC), zeta-potential measurements, and particle size distribution. A marked increase in the PX dissolution rate was observed even in binary and ternary complexes. The presence of HPMC in ternary complexes slightly retarded the release of PX. Cyclodextrin complexation increased the PX concentration gradient over the semipermeable membrane, resulting in an increased PX flux. The retarded diffusion of PX to the membrane interface decreased the PX flux values of the ternary complexes. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/15595571/Multicomponent_complexes_of_piroxicam_with_cyclodextrins_and_hydroxypropyl_methylcellulose_ L2 - https://www.tandfonline.com/doi/full/10.1081/ddc-200040245 DB - PRIME DP - Unbound Medicine ER -