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Rapid intake of alcohol (binge drinking) inhibits platelet adhesion to fibrinogen under flow.

Abstract

BACKGROUND

Moderate alcohol consumption is associated with decreased mortality from cardiovascular disease. Drinking large amounts in a short period (binge drinking) is associated with increased cardiovascular morbidity. We tested whether rapid consumption of a large dose of alcohol affects platelet aggregation and adhesion.

METHODS

Healthy volunteers (n = 20) were asked to drink three glasses of alcohol or red wine in a 45-min period. Thereafter, another 45 min was allowed for absorption of alcohol. Ninety minutes after the start of the experiment, blood was collected. This entire cycle was repeated once, resulting in consumption of six alcohol-containing drinks in 3 hr. Adenosine-diphosphate (ADP)-induced aggregation was measured and platelet adhesion to fibrinogen and collagen was measured in a perfusion chamber at shear rates of 300/sec and 1600/sec. Platelet coverage and aggregate size were measured.

RESULTS

Acute alcohol intake significantly increased platelet aggregation in suspension when stimulated with low concentrations of ADP (0.1 and 0.5 microg/ml). This effect was not observed when consuming red wine. In contrast, adhesion to fibrinogen was significantly inhibited by alcohol but not red wine at high shear rate after six drinks (p = 0.025). The inhibition was accompanied by a reduction in aggregate size at 90 and 180 min after the start of the experiment. Adhesion to collagen was not altered by either alcohol or red wine.

CONCLUSIONS

Rapid intake of alcohol increases platelet aggregation, which might contribute to the increased mortality associated with binge drinking. Red wine does not show increased platelet aggregation, which might support the reduction of cardiovascular disease in red wine consumers. However, alcohol inhibits platelet adhesion to fibrinogen-coated surface under flow. The diminished adhesion might contribute to the cardioprotective effects of alcohol.

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  • Authors+Show Affiliations

    ,

    Thrombosis and Haemostasis Laboratory, University Medical Center Utrecht and Institute for Biomembranes University Utrecht, The Netherlands. D.W.deLange@azu.nl

    , , , , ,

    Source

    MeSH

    Adult
    Alcohol Drinking
    Analysis of Variance
    Ethanol
    Female
    Fibrinogen
    Humans
    Male
    Platelet Adhesiveness
    Platelet Aggregation
    Time Factors
    Wine

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15597090

    Citation

    de Lange, Dylan W., et al. "Rapid Intake of Alcohol (binge Drinking) Inhibits Platelet Adhesion to Fibrinogen Under Flow." Alcoholism, Clinical and Experimental Research, vol. 28, no. 10, 2004, pp. 1562-8.
    de Lange DW, Hijmering ML, Lorsheyd A, et al. Rapid intake of alcohol (binge drinking) inhibits platelet adhesion to fibrinogen under flow. Alcohol Clin Exp Res. 2004;28(10):1562-8.
    de Lange, D. W., Hijmering, M. L., Lorsheyd, A., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., & van de Wiel, A. (2004). Rapid intake of alcohol (binge drinking) inhibits platelet adhesion to fibrinogen under flow. Alcoholism, Clinical and Experimental Research, 28(10), pp. 1562-8.
    de Lange DW, et al. Rapid Intake of Alcohol (binge Drinking) Inhibits Platelet Adhesion to Fibrinogen Under Flow. Alcohol Clin Exp Res. 2004;28(10):1562-8. PubMed PMID: 15597090.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Rapid intake of alcohol (binge drinking) inhibits platelet adhesion to fibrinogen under flow. AU - de Lange,Dylan W, AU - Hijmering,Michael L, AU - Lorsheyd,Anouk, AU - Scholman,Wilco L G, AU - Kraaijenhagen,Rob J, AU - Akkerman,Jan-Willem N, AU - van de Wiel,Albert, PY - 2004/12/15/pubmed PY - 2005/1/19/medline PY - 2004/12/15/entrez SP - 1562 EP - 8 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 28 IS - 10 N2 - BACKGROUND: Moderate alcohol consumption is associated with decreased mortality from cardiovascular disease. Drinking large amounts in a short period (binge drinking) is associated with increased cardiovascular morbidity. We tested whether rapid consumption of a large dose of alcohol affects platelet aggregation and adhesion. METHODS: Healthy volunteers (n = 20) were asked to drink three glasses of alcohol or red wine in a 45-min period. Thereafter, another 45 min was allowed for absorption of alcohol. Ninety minutes after the start of the experiment, blood was collected. This entire cycle was repeated once, resulting in consumption of six alcohol-containing drinks in 3 hr. Adenosine-diphosphate (ADP)-induced aggregation was measured and platelet adhesion to fibrinogen and collagen was measured in a perfusion chamber at shear rates of 300/sec and 1600/sec. Platelet coverage and aggregate size were measured. RESULTS: Acute alcohol intake significantly increased platelet aggregation in suspension when stimulated with low concentrations of ADP (0.1 and 0.5 microg/ml). This effect was not observed when consuming red wine. In contrast, adhesion to fibrinogen was significantly inhibited by alcohol but not red wine at high shear rate after six drinks (p = 0.025). The inhibition was accompanied by a reduction in aggregate size at 90 and 180 min after the start of the experiment. Adhesion to collagen was not altered by either alcohol or red wine. CONCLUSIONS: Rapid intake of alcohol increases platelet aggregation, which might contribute to the increased mortality associated with binge drinking. Red wine does not show increased platelet aggregation, which might support the reduction of cardiovascular disease in red wine consumers. However, alcohol inhibits platelet adhesion to fibrinogen-coated surface under flow. The diminished adhesion might contribute to the cardioprotective effects of alcohol. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/15597090/Rapid_intake_of_alcohol__binge_drinking__inhibits_platelet_adhesion_to_fibrinogen_under_flow_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2004&volume=28&issue=10&spage=1562 DB - PRIME DP - Unbound Medicine ER -