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Antiulcer activity of methanol fraction of Barleria lupulina Lindl. in animal models.
Phytother Res. 2004 Nov; 18(11):925-9.PR

Abstract

The objective of the present study was to evaluate the gastric cytoprotective activity of the methanol extract of aerial parts of the plant Barleria lupulina Lindl (Acanthaceae) in albino rats using various models of ulcers such as drug induced ulcers, restraint ulcers, duodenal ulcers and pylorus ligated ulcers. The effect of the extract on gastric secretion and lipid peroxidation (thiobarbituric acid reacting substances TBARS) was also studied in rats. The extract at the tested dose of 200 mg/kg significantly reduced the volume of gastric juice, total acidity and the ulcer index in pylorus ligated rats. It also afforded significant protection against alcohol and indomethacin induced ulcer as well as stress induced ulceration. TBARS in the stomach of indomethacin treated rats was also reduced. In addition, it gave protection against duodenal ulcers. The study suggests that the methanol extract of aerial parts of Barleria lupulina Lindl. has a protective effect against experimental gastric and duodenal ulcers.

Authors+Show Affiliations

Suba V
Department of Pharmaceutical Technology, Jadavpur University, Calcutta-700 032, India.
Murugesan T
No affiliation info available
Pal M
No affiliation info available
Mandal SC
No affiliation info available
Saha BP
No affiliation info available

MeSH

AcanthaceaeAnimalsAnti-Ulcer AgentsDuodenal UlcerEthanolFemaleGastric MucosaIndomethacinLipid PeroxidationMalePhytotherapyPlant Components, AerialPlant ExtractsRatsStomachStomach UlcerThiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15597309

Citation

Suba, V, et al. "Antiulcer Activity of Methanol Fraction of Barleria Lupulina Lindl. in Animal Models." Phytotherapy Research : PTR, vol. 18, no. 11, 2004, pp. 925-9.
Suba V, Murugesan T, Pal M, et al. Antiulcer activity of methanol fraction of Barleria lupulina Lindl. in animal models. Phytother Res. 2004;18(11):925-9.
Suba, V., Murugesan, T., Pal, M., Mandal, S. C., & Saha, B. P. (2004). Antiulcer activity of methanol fraction of Barleria lupulina Lindl. in animal models. Phytotherapy Research : PTR, 18(11), 925-9.
Suba V, et al. Antiulcer Activity of Methanol Fraction of Barleria Lupulina Lindl. in Animal Models. Phytother Res. 2004;18(11):925-9. PubMed PMID: 15597309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcer activity of methanol fraction of Barleria lupulina Lindl. in animal models. AU - Suba,V, AU - Murugesan,T, AU - Pal,M, AU - Mandal,Subhash C, AU - Saha,B P, PY - 2004/12/15/pubmed PY - 2005/3/1/medline PY - 2004/12/15/entrez SP - 925 EP - 9 JF - Phytotherapy research : PTR JO - Phytother Res VL - 18 IS - 11 N2 - The objective of the present study was to evaluate the gastric cytoprotective activity of the methanol extract of aerial parts of the plant Barleria lupulina Lindl (Acanthaceae) in albino rats using various models of ulcers such as drug induced ulcers, restraint ulcers, duodenal ulcers and pylorus ligated ulcers. The effect of the extract on gastric secretion and lipid peroxidation (thiobarbituric acid reacting substances TBARS) was also studied in rats. The extract at the tested dose of 200 mg/kg significantly reduced the volume of gastric juice, total acidity and the ulcer index in pylorus ligated rats. It also afforded significant protection against alcohol and indomethacin induced ulcer as well as stress induced ulceration. TBARS in the stomach of indomethacin treated rats was also reduced. In addition, it gave protection against duodenal ulcers. The study suggests that the methanol extract of aerial parts of Barleria lupulina Lindl. has a protective effect against experimental gastric and duodenal ulcers. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/15597309/Antiulcer_activity_of_methanol_fraction_of_Barleria_lupulina_Lindl__in_animal_models_ DB - PRIME DP - Unbound Medicine ER -