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[Risk factors for cognitive impairment].

Abstract

Cognitive impairment is an invalidating condition and its prevalence increases significantly with age. It is very important to identify the risk factors for cognitive impairment. Aside from age, sex, familiary history and educational level, the other major risk factors (hypertension, hypercolesterolemia, diabetes mellitus and tobacco), known to be associated frequently with different cerebrovascular diseases, might also contribute to degenerative forms of cognitive impairment because they might favour cerebral microvascular alterations with hypoperfusion, demyelinization and ischemic lesions of subcortical white matter. Longitudinal epidemiological studies detected that arterial hypertension, hypercolesterolemia and tobacco are frequently associated with degenerative forms of cognitive impairment. Some studies show there is no relationship between cognitive impairment and diabetes mellitus, while other underline its role; light alcohol drinking might protect against cognitive impairment. Other recently identified risk factors might be hyperhomocysteinemia and high C-reactive protein blood levels because they seem to be associated with cognitive impairment.

Authors+Show Affiliations

,

Dipartimento di Scienze dell'Invecchiamento, Università La Sapienza, Roma. paolocicconetti@tin.it

, , ,

Source

Recenti progressi in medicina 95:11 2004 Nov pg 535-45

MeSH

Age Factors
Aged
Aged, 80 and over
Alcohol Drinking
Alzheimer Disease
C-Reactive Protein
Cerebrovascular Disorders
Cognition Disorders
Cohort Studies
Comorbidity
Cross-Sectional Studies
Dementia
Diabetes Mellitus
Diagnosis, Differential
Female
Humans
Hypercholesterolemia
Hyperhomocysteinemia
Hypertension
Longitudinal Studies
Male
Middle Aged
Placebos
Randomized Controlled Trials as Topic
Risk Factors
Sex Factors
Smoking

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Review

Language

ita

PubMed ID

15598092

Citation

Cicconetti, Paolo, et al. "[Risk Factors for Cognitive Impairment]." Recenti Progressi in Medicina, vol. 95, no. 11, 2004, pp. 535-45.
Cicconetti P, Riolo N, Priami C, et al. [Risk factors for cognitive impairment]. Recenti Prog Med. 2004;95(11):535-45.
Cicconetti, P., Riolo, N., Priami, C., Tafaro, L., & Ettore, E. (2004). [Risk factors for cognitive impairment]. Recenti Progressi in Medicina, 95(11), pp. 535-45.
Cicconetti P, et al. [Risk Factors for Cognitive Impairment]. Recenti Prog Med. 2004;95(11):535-45. PubMed PMID: 15598092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Risk factors for cognitive impairment]. AU - Cicconetti,Paolo, AU - Riolo,Noemi, AU - Priami,Carolina, AU - Tafaro,Laura, AU - Ettore,Evaristo, PY - 2004/12/16/pubmed PY - 2005/1/11/medline PY - 2004/12/16/entrez SP - 535 EP - 45 JF - Recenti progressi in medicina JO - Recenti Prog Med VL - 95 IS - 11 N2 - Cognitive impairment is an invalidating condition and its prevalence increases significantly with age. It is very important to identify the risk factors for cognitive impairment. Aside from age, sex, familiary history and educational level, the other major risk factors (hypertension, hypercolesterolemia, diabetes mellitus and tobacco), known to be associated frequently with different cerebrovascular diseases, might also contribute to degenerative forms of cognitive impairment because they might favour cerebral microvascular alterations with hypoperfusion, demyelinization and ischemic lesions of subcortical white matter. Longitudinal epidemiological studies detected that arterial hypertension, hypercolesterolemia and tobacco are frequently associated with degenerative forms of cognitive impairment. Some studies show there is no relationship between cognitive impairment and diabetes mellitus, while other underline its role; light alcohol drinking might protect against cognitive impairment. Other recently identified risk factors might be hyperhomocysteinemia and high C-reactive protein blood levels because they seem to be associated with cognitive impairment. SN - 0034-1193 UR - https://www.unboundmedicine.com/medline/citation/15598092/[Risk_factors_for_cognitive_impairment]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -