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Schizophrenia and obesity: impact of antipsychotic medications.
J Clin Psychiatry. 2004; 65 Suppl 18:13-26.JC

Abstract

Obesity is an epidemic in this country and much of the rest of the developed world. It is a major contributor to a range of metabolic disorders responsible for much of the medical morbidity and mortality that burden our society. The combination of the costs to society of the chronic illness of schizophrenia with the costs of obesity and the chronic illnesses associated with it, e.g., metabolic disorders, diabetes, dyslipidemias, and cardiovascular disease, represents a major public health problem. Obesity in schizophrenia is accentuated even further largely through illness-related factors, like poor dietary conditions and more sedentary lifestyles, and particularly because many of the psychiatric medications (antipsychotics, mood stabilizers, and antidepressants) used to combat this devastating illness themselves result in weight gain that, if untreated, may result in the usual obesity-associated morbidity and mortality. This article is intended to review some of the physiology of obesity and obesity-related metabolic disorders, the risks to schizophrenia patients engendered by obesity, the evidence for weight gain associated with the antipsychotic drugs, and the possible mechanisms involved in antipsychotic medication-associated weight gain.

Authors+Show Affiliations

Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Donna.Wirshing@med.va.gov

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15600381

Citation

Wirshing, Donna A.. "Schizophrenia and Obesity: Impact of Antipsychotic Medications." The Journal of Clinical Psychiatry, vol. 65 Suppl 18, 2004, pp. 13-26.
Wirshing DA. Schizophrenia and obesity: impact of antipsychotic medications. J Clin Psychiatry. 2004;65 Suppl 18:13-26.
Wirshing, D. A. (2004). Schizophrenia and obesity: impact of antipsychotic medications. The Journal of Clinical Psychiatry, 65 Suppl 18, 13-26.
Wirshing DA. Schizophrenia and Obesity: Impact of Antipsychotic Medications. J Clin Psychiatry. 2004;65 Suppl 18:13-26. PubMed PMID: 15600381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Schizophrenia and obesity: impact of antipsychotic medications. A1 - Wirshing,Donna A, PY - 2004/12/17/pubmed PY - 2005/2/3/medline PY - 2004/12/17/entrez SP - 13 EP - 26 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 65 Suppl 18 N2 - Obesity is an epidemic in this country and much of the rest of the developed world. It is a major contributor to a range of metabolic disorders responsible for much of the medical morbidity and mortality that burden our society. The combination of the costs to society of the chronic illness of schizophrenia with the costs of obesity and the chronic illnesses associated with it, e.g., metabolic disorders, diabetes, dyslipidemias, and cardiovascular disease, represents a major public health problem. Obesity in schizophrenia is accentuated even further largely through illness-related factors, like poor dietary conditions and more sedentary lifestyles, and particularly because many of the psychiatric medications (antipsychotics, mood stabilizers, and antidepressants) used to combat this devastating illness themselves result in weight gain that, if untreated, may result in the usual obesity-associated morbidity and mortality. This article is intended to review some of the physiology of obesity and obesity-related metabolic disorders, the risks to schizophrenia patients engendered by obesity, the evidence for weight gain associated with the antipsychotic drugs, and the possible mechanisms involved in antipsychotic medication-associated weight gain. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/15600381/Schizophrenia_and_obesity:_impact_of_antipsychotic_medications_ L2 - http://www.psychiatrist.com/jcp/article/pages/2004/v65s18/v65s1802.aspx DB - PRIME DP - Unbound Medicine ER -