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Abnormalities of glucose metabolism associated with atypical antipsychotic drugs.
J Clin Psychiatry. 2004; 65 Suppl 18:36-46.JC

Abstract

The introduction of atypical antipsychotic drugs has provided a clear benefit for many schizophrenia patients, with less risk for the extrapyramidal side effects associated with conventional antipsychotics. However, some antipsychotics are associated with an increased risk of adverse metabolic outcomes, including weight gain, dyslipidemia, and hyperglycemia. Increases in adiposity and disturbances in glucose and lipid metabolism represent a serious health risk in a patient that may be predisposed to these metabolic conditions. The increased risk for diabetes with certain antipsychotics may be associated with the risk of treatment-induced weight gain. However, other mechanisms, including effects on central neurotransmitters and direct effects on glucose metabolism, may contribute to the development of disordered glucose metabolism. The purpose of this article is to review the association between antipsychotic medications and obesity, insulin resistance, and diabetes, including the mechanisms through which these changes might be effected.

Authors+Show Affiliations

Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. newcomerj@psychiatry.wustl.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15600383

Citation

Newcomer, John W.. "Abnormalities of Glucose Metabolism Associated With Atypical Antipsychotic Drugs." The Journal of Clinical Psychiatry, vol. 65 Suppl 18, 2004, pp. 36-46.
Newcomer JW. Abnormalities of glucose metabolism associated with atypical antipsychotic drugs. J Clin Psychiatry. 2004;65 Suppl 18:36-46.
Newcomer, J. W. (2004). Abnormalities of glucose metabolism associated with atypical antipsychotic drugs. The Journal of Clinical Psychiatry, 65 Suppl 18, 36-46.
Newcomer JW. Abnormalities of Glucose Metabolism Associated With Atypical Antipsychotic Drugs. J Clin Psychiatry. 2004;65 Suppl 18:36-46. PubMed PMID: 15600383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormalities of glucose metabolism associated with atypical antipsychotic drugs. A1 - Newcomer,John W, PY - 2004/12/17/pubmed PY - 2005/2/3/medline PY - 2004/12/17/entrez SP - 36 EP - 46 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 65 Suppl 18 N2 - The introduction of atypical antipsychotic drugs has provided a clear benefit for many schizophrenia patients, with less risk for the extrapyramidal side effects associated with conventional antipsychotics. However, some antipsychotics are associated with an increased risk of adverse metabolic outcomes, including weight gain, dyslipidemia, and hyperglycemia. Increases in adiposity and disturbances in glucose and lipid metabolism represent a serious health risk in a patient that may be predisposed to these metabolic conditions. The increased risk for diabetes with certain antipsychotics may be associated with the risk of treatment-induced weight gain. However, other mechanisms, including effects on central neurotransmitters and direct effects on glucose metabolism, may contribute to the development of disordered glucose metabolism. The purpose of this article is to review the association between antipsychotic medications and obesity, insulin resistance, and diabetes, including the mechanisms through which these changes might be effected. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/15600383/Abnormalities_of_glucose_metabolism_associated_with_atypical_antipsychotic_drugs_ L2 - http://www.psychiatrist.com/jcp/article/pages/2004/v65s18/v65s1804.aspx DB - PRIME DP - Unbound Medicine ER -