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Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section.
Anaesthesia 2005; 60(1):28-34A

Abstract

This study compared the effects of intravenous infusions of ephedrine and mephentermine for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine. Hypotension was defined as a decrease in systolic blood pressure of > or = 20% from the baseline value or an absolute value of <100 mmHg, whichever was higher. The vasopressor infusion was titrated to maintain systolic blood pressure between 'hypotension' and baseline values. Baseline haemodynamic parameters, haemodynamic changes subsequent to the start of vasopressor infusion, duration of hypotension and amount of vasopressor required were statistically similar for both groups. Neonatal APGAR scores and acid-base profiles were also comparable. To conclude, mephentermine can be used as safely and effectively as ephedrine for the management of hypotension during spinal anaesthesia in patients undergoing elective Caesarean section.

Authors+Show Affiliations

Department of Anaesthesiology and Critical care, University College of Medical Sciences, Guru Teg Bahadur Hospital, Delhi 110096, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15601269

Citation

Kansal, A, et al. "Randomised Trial of Intravenous Infusion of Ephedrine or Mephentermine for Management of Hypotension During Spinal Anaesthesia for Caesarean Section." Anaesthesia, vol. 60, no. 1, 2005, pp. 28-34.
Kansal A, Mohta M, Sethi AK, et al. Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. Anaesthesia. 2005;60(1):28-34.
Kansal, A., Mohta, M., Sethi, A. K., Tyagi, A., & Kumar, P. (2005). Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. Anaesthesia, 60(1), pp. 28-34.
Kansal A, et al. Randomised Trial of Intravenous Infusion of Ephedrine or Mephentermine for Management of Hypotension During Spinal Anaesthesia for Caesarean Section. Anaesthesia. 2005;60(1):28-34. PubMed PMID: 15601269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. AU - Kansal,A, AU - Mohta,M, AU - Sethi,A K, AU - Tyagi,A, AU - Kumar,P, PY - 2004/12/17/pubmed PY - 2005/1/28/medline PY - 2004/12/17/entrez SP - 28 EP - 34 JF - Anaesthesia JO - Anaesthesia VL - 60 IS - 1 N2 - This study compared the effects of intravenous infusions of ephedrine and mephentermine for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine. Hypotension was defined as a decrease in systolic blood pressure of > or = 20% from the baseline value or an absolute value of <100 mmHg, whichever was higher. The vasopressor infusion was titrated to maintain systolic blood pressure between 'hypotension' and baseline values. Baseline haemodynamic parameters, haemodynamic changes subsequent to the start of vasopressor infusion, duration of hypotension and amount of vasopressor required were statistically similar for both groups. Neonatal APGAR scores and acid-base profiles were also comparable. To conclude, mephentermine can be used as safely and effectively as ephedrine for the management of hypotension during spinal anaesthesia in patients undergoing elective Caesarean section. SN - 0003-2409 UR - https://www.unboundmedicine.com/medline/citation/15601269/Randomised_trial_of_intravenous_infusion_of_ephedrine_or_mephentermine_for_management_of_hypotension_during_spinal_anaesthesia_for_Caesarean_section_ L2 - https://doi.org/10.1111/j.1365-2044.2004.03994.x DB - PRIME DP - Unbound Medicine ER -