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The herbal preparation STW5 (lberogast) has potent and region-specific effects on gastric motility.
Neurogastroenterol Motil. 2004 Dec; 16(6):765-73.NM

Abstract

Functional dyspepsia (FD) is amongst the most common functional gastrointestinal disorders. Symptomatic treatment includes the use of herbal preparations whose effects on gastric motility are unclear. The present study aimed at investigating the effects of STW 5 (Iberogast), a fixed combination of hydroethanolic herbal extracts, on gastric motility in vitro. Muscle strips from guinea-pig gastric fundus, corpus and antrum were set up in organ baths either in circular or longitudinal orientation. Addition of ethanol-free STW 5 to the organ baths (32-512 microg mL(-1)) dose-dependently evoked a sustained and reversible relaxation of circular and longitudinal fundus and corpus muscle strips without changes in phasic activity. In contrast, antral muscle strips responded to STW 5 with a significant increase in the contractile force of phasic contractions without changes in tone. All effects were resistant to tetrodotoxin (0.5 micromol L(-1)), atropine (1 micromol L(-1)), omega-conotoxin GVIA (0.5 micromol L(-1)), capsaicin (1 micromol L(-1)) or L-NAME (100 micromol L(-1)), suggesting that neither nerves nor nitric oxide pathways were involved. These data demonstrate that STW 5 profoundly alters gastric motility in a region-specific but not layer-specific manner and thus implicates Iberogast in the treatment of FD patients suffering from motility disorders with impaired fundus accommodation and/or antral hypomotility.

Authors+Show Affiliations

Department of Human Biology, Technical University Munich, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15601427

Citation

Hohenester, B, et al. "The Herbal Preparation STW5 (lberogast) Has Potent and Region-specific Effects On Gastric Motility." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 16, no. 6, 2004, pp. 765-73.
Hohenester B, Rühl A, Kelber O, et al. The herbal preparation STW5 (lberogast) has potent and region-specific effects on gastric motility. Neurogastroenterol Motil. 2004;16(6):765-73.
Hohenester, B., Rühl, A., Kelber, O., & Schemann, M. (2004). The herbal preparation STW5 (lberogast) has potent and region-specific effects on gastric motility. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 16(6), 765-73.
Hohenester B, et al. The Herbal Preparation STW5 (lberogast) Has Potent and Region-specific Effects On Gastric Motility. Neurogastroenterol Motil. 2004;16(6):765-73. PubMed PMID: 15601427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The herbal preparation STW5 (lberogast) has potent and region-specific effects on gastric motility. AU - Hohenester,B, AU - Rühl,A, AU - Kelber,O, AU - Schemann,M, PY - 2004/12/17/pubmed PY - 2005/2/3/medline PY - 2004/12/17/entrez SP - 765 EP - 73 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 16 IS - 6 N2 - Functional dyspepsia (FD) is amongst the most common functional gastrointestinal disorders. Symptomatic treatment includes the use of herbal preparations whose effects on gastric motility are unclear. The present study aimed at investigating the effects of STW 5 (Iberogast), a fixed combination of hydroethanolic herbal extracts, on gastric motility in vitro. Muscle strips from guinea-pig gastric fundus, corpus and antrum were set up in organ baths either in circular or longitudinal orientation. Addition of ethanol-free STW 5 to the organ baths (32-512 microg mL(-1)) dose-dependently evoked a sustained and reversible relaxation of circular and longitudinal fundus and corpus muscle strips without changes in phasic activity. In contrast, antral muscle strips responded to STW 5 with a significant increase in the contractile force of phasic contractions without changes in tone. All effects were resistant to tetrodotoxin (0.5 micromol L(-1)), atropine (1 micromol L(-1)), omega-conotoxin GVIA (0.5 micromol L(-1)), capsaicin (1 micromol L(-1)) or L-NAME (100 micromol L(-1)), suggesting that neither nerves nor nitric oxide pathways were involved. These data demonstrate that STW 5 profoundly alters gastric motility in a region-specific but not layer-specific manner and thus implicates Iberogast in the treatment of FD patients suffering from motility disorders with impaired fundus accommodation and/or antral hypomotility. SN - 1350-1925 UR - https://www.unboundmedicine.com/medline/citation/15601427/The_herbal_preparation_STW5__lberogast__has_potent_and_region_specific_effects_on_gastric_motility_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1350-1925&date=2004&volume=16&issue=6&spage=765 DB - PRIME DP - Unbound Medicine ER -