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In vitro evaluation of griseofulvin against clinical isolates of dermatophytes from Isfahan.
Mycoses. 2004 Dec; 47(11-12):503-7.M

Abstract

Fifty dermatophyte isolates, recently obtained from clinical materials, belonging to Trichophyton mentagrophytes, T. verrucosum, Microsporum canis and Epidermophyton floccosum were examined for their susceptibility to griseofulvin. The minimum inhibitory concentration (MIC) values were obtained using the modified microdilution method. All 100% tested isolates had MIC geometric mean at a concentration between 0.43 and 0.95 microg ml(-1) The MIC(90)s and MIC(50)s were 8 microg ml(-1) and <0.25-1 microg ml(-1) respectively. From all isolates, 12% including three T. verrucosum, one M. canis and two T. mentagrophytes isolates had MIC values out of the standardized range, therefore, they were considered as relatively griseofulvin-resistant. At least some of the isolates tested might be difficult to eradicate in clinical terms with griseofulvin treatment in Isfahan.

Authors+Show Affiliations

Chadeganipour M
Mycology and Parasitology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. chadeganipour@med.mui.ac.ir
Nilipour S
No affiliation info available
Havaei A
No affiliation info available

MeSH

Antifungal AgentsArthrodermataceaeDrug Resistance, FungalEpidermophytonGriseofulvinIranMicrobial Sensitivity TestsMicrosporumTrichophyton

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15601457

Citation

Chadeganipour, Mostafa, et al. "In Vitro Evaluation of Griseofulvin Against Clinical Isolates of Dermatophytes From Isfahan." Mycoses, vol. 47, no. 11-12, 2004, pp. 503-7.
Chadeganipour M, Nilipour S, Havaei A. In vitro evaluation of griseofulvin against clinical isolates of dermatophytes from Isfahan. Mycoses. 2004;47(11-12):503-7.
Chadeganipour, M., Nilipour, S., & Havaei, A. (2004). In vitro evaluation of griseofulvin against clinical isolates of dermatophytes from Isfahan. Mycoses, 47(11-12), 503-7.
Chadeganipour M, Nilipour S, Havaei A. In Vitro Evaluation of Griseofulvin Against Clinical Isolates of Dermatophytes From Isfahan. Mycoses. 2004;47(11-12):503-7. PubMed PMID: 15601457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro evaluation of griseofulvin against clinical isolates of dermatophytes from Isfahan. AU - Chadeganipour,Mostafa, AU - Nilipour,Shahi, AU - Havaei,Asghar, PY - 2004/12/17/pubmed PY - 2005/7/7/medline PY - 2004/12/17/entrez SP - 503 EP - 7 JF - Mycoses JO - Mycoses VL - 47 IS - 11-12 N2 - Fifty dermatophyte isolates, recently obtained from clinical materials, belonging to Trichophyton mentagrophytes, T. verrucosum, Microsporum canis and Epidermophyton floccosum were examined for their susceptibility to griseofulvin. The minimum inhibitory concentration (MIC) values were obtained using the modified microdilution method. All 100% tested isolates had MIC geometric mean at a concentration between 0.43 and 0.95 microg ml(-1) The MIC(90)s and MIC(50)s were 8 microg ml(-1) and <0.25-1 microg ml(-1) respectively. From all isolates, 12% including three T. verrucosum, one M. canis and two T. mentagrophytes isolates had MIC values out of the standardized range, therefore, they were considered as relatively griseofulvin-resistant. At least some of the isolates tested might be difficult to eradicate in clinical terms with griseofulvin treatment in Isfahan. SN - 0933-7407 UR - https://www.unboundmedicine.com/medline/citation/15601457/In_vitro_evaluation_of_griseofulvin_against_clinical_isolates_of_dermatophytes_from_Isfahan_ DB - PRIME DP - Unbound Medicine ER -