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Hepatitis C and nonalcoholic fatty liver disease.
Semin Liver Dis. 2004 Nov; 24(4):399-413.SL

Abstract

Hepatitis C virus (HCV) and nonalcoholic fatty liver disease (NAFLD) are the two most common causes of chronic liver disease in North America. NAFLD represents a spectrum of liver lesions that occur in individuals who either do not consume any alcohol or only consume alcohol in quantities generally considered not to be harmful to the liver. This spectrum consists of isolated hepatic macrovesicular steatosis at one end and nonalcoholic steatohepatitis (NASH) at the other. Hepatic steatosis is present in approximately 50% of the subjects with HCV. Genotype 3 is independently associated with hepatic steatosis. In those with genotype 1 infection, steatosis is associated with features of the metabolic syndrome. The presence of hepatic steatosis correlates with the stage of hepatic fibrosis in patients with HCV. This has been related to the presence of insulin resistance. Hepatic steatosis also adversely affects the virologic response rates to anti-HCV therapy. In this article, we will review the epidemiology of HCV and NAFLD, their impact on each other, and the course of the liver disease in individuals afflicted with both conditions.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15605308

Citation

Ramesh, Seela, and Arun J. Sanyal. "Hepatitis C and Nonalcoholic Fatty Liver Disease." Seminars in Liver Disease, vol. 24, no. 4, 2004, pp. 399-413.
Ramesh S, Sanyal AJ. Hepatitis C and nonalcoholic fatty liver disease. Semin Liver Dis. 2004;24(4):399-413.
Ramesh, S., & Sanyal, A. J. (2004). Hepatitis C and nonalcoholic fatty liver disease. Seminars in Liver Disease, 24(4), 399-413.
Ramesh S, Sanyal AJ. Hepatitis C and Nonalcoholic Fatty Liver Disease. Semin Liver Dis. 2004;24(4):399-413. PubMed PMID: 15605308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C and nonalcoholic fatty liver disease. AU - Ramesh,Seela, AU - Sanyal,Arun J, PY - 2004/12/18/pubmed PY - 2005/3/19/medline PY - 2004/12/18/entrez SP - 399 EP - 413 JF - Seminars in liver disease JO - Semin Liver Dis VL - 24 IS - 4 N2 - Hepatitis C virus (HCV) and nonalcoholic fatty liver disease (NAFLD) are the two most common causes of chronic liver disease in North America. NAFLD represents a spectrum of liver lesions that occur in individuals who either do not consume any alcohol or only consume alcohol in quantities generally considered not to be harmful to the liver. This spectrum consists of isolated hepatic macrovesicular steatosis at one end and nonalcoholic steatohepatitis (NASH) at the other. Hepatic steatosis is present in approximately 50% of the subjects with HCV. Genotype 3 is independently associated with hepatic steatosis. In those with genotype 1 infection, steatosis is associated with features of the metabolic syndrome. The presence of hepatic steatosis correlates with the stage of hepatic fibrosis in patients with HCV. This has been related to the presence of insulin resistance. Hepatic steatosis also adversely affects the virologic response rates to anti-HCV therapy. In this article, we will review the epidemiology of HCV and NAFLD, their impact on each other, and the course of the liver disease in individuals afflicted with both conditions. SN - 0272-8087 UR - https://www.unboundmedicine.com/medline/citation/15605308/Hepatitis_C_and_nonalcoholic_fatty_liver_disease_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-860869 DB - PRIME DP - Unbound Medicine ER -