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Oesophageal pH has a power-law distribution in control and gastro-oesophageal reflux disease subjects.
Aliment Pharmacol Ther 2004; 20(11-12):1373-9AP

Abstract

BACKGROUND

We are unaware of any solid theoretical or pathophysiological basis for selecting pH 4 or any other pH value to assess oesophageal acid exposure or to define oesophageal reflux episodes.

AIM

To examine the frequency of different oesophageal pH values in control and GERD subjects.

METHODS

Oesophageal pH was measured for 24 h in 57 gastro-oesophageal reflux disease subjects and 26 control subjects. Histograms were constructed using the 21,600 values from each recording and bins of 0.25 pH units.

RESULTS

Compared with controls, gastro-oesophageal reflux disease subjects had significantly more low pH values and significantly fewer high pH values. In both gastro-oesophageal reflux disease and control subjects, the frequency of oesophageal pH values was characterized by a power-law distribution indicating that the same relationship that describes low pH values also describes high pH values, as well as all values in between.

CONCLUSIONS

The distribution of oesophageal pH values indicates that a variety of different pH values can be used to assess oesophageal acid exposure, but raises important questions regarding how oesophageal reflux episodes are defined.

Authors+Show Affiliations

Science for Organizations, Inc., Chatham, NJ 07928, USA. gardnerj@scifororg.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15606400

Citation

Gardner, J D., et al. "Oesophageal pH Has a Power-law Distribution in Control and Gastro-oesophageal Reflux Disease Subjects." Alimentary Pharmacology & Therapeutics, vol. 20, no. 11-12, 2004, pp. 1373-9.
Gardner JD, Sloan S, Robinson M, et al. Oesophageal pH has a power-law distribution in control and gastro-oesophageal reflux disease subjects. Aliment Pharmacol Ther. 2004;20(11-12):1373-9.
Gardner, J. D., Sloan, S., Robinson, M., & Miner, P. B. (2004). Oesophageal pH has a power-law distribution in control and gastro-oesophageal reflux disease subjects. Alimentary Pharmacology & Therapeutics, 20(11-12), pp. 1373-9.
Gardner JD, et al. Oesophageal pH Has a Power-law Distribution in Control and Gastro-oesophageal Reflux Disease Subjects. Aliment Pharmacol Ther. 2004;20(11-12):1373-9. PubMed PMID: 15606400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oesophageal pH has a power-law distribution in control and gastro-oesophageal reflux disease subjects. AU - Gardner,J D, AU - Sloan,S, AU - Robinson,M, AU - Miner,P B, PY - 2004/12/21/pubmed PY - 2005/6/4/medline PY - 2004/12/21/entrez SP - 1373 EP - 9 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 20 IS - 11-12 N2 - BACKGROUND: We are unaware of any solid theoretical or pathophysiological basis for selecting pH 4 or any other pH value to assess oesophageal acid exposure or to define oesophageal reflux episodes. AIM: To examine the frequency of different oesophageal pH values in control and GERD subjects. METHODS: Oesophageal pH was measured for 24 h in 57 gastro-oesophageal reflux disease subjects and 26 control subjects. Histograms were constructed using the 21,600 values from each recording and bins of 0.25 pH units. RESULTS: Compared with controls, gastro-oesophageal reflux disease subjects had significantly more low pH values and significantly fewer high pH values. In both gastro-oesophageal reflux disease and control subjects, the frequency of oesophageal pH values was characterized by a power-law distribution indicating that the same relationship that describes low pH values also describes high pH values, as well as all values in between. CONCLUSIONS: The distribution of oesophageal pH values indicates that a variety of different pH values can be used to assess oesophageal acid exposure, but raises important questions regarding how oesophageal reflux episodes are defined. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15606400/Oesophageal_pH_has_a_power_law_distribution_in_control_and_gastro_oesophageal_reflux_disease_subjects_ L2 - https://doi.org/10.1111/j.1365-2036.2004.02278.x DB - PRIME DP - Unbound Medicine ER -