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Frequency analyses of gastric pH in control and gastro-oesophageal reflux disease subjects treated with a proton-pump inhibitor.
Aliment Pharmacol Ther 2004; 20(11-12):1381-6AP

Abstract

BACKGROUND

We are unaware of any solid theoretical or pathophysiological basis for selecting pH 4 or any other pH value to assess gastric acidity.

AIM

To examine the frequency of different gastric pH values in control and GERD subjects.

METHODS

Gastric pH was measured for 24 h in 26 control subjects, 26 gastro-oesophageal reflux disease subjects at baseline and the same 26 gastro-oesophageal reflux disease subjects during treatment with a proton-pump inhibitor. Histograms were constructed using the 21 600 values generated from each recording and bins of 0.25 pH units.

RESULTS

The distribution of gastric pH values in gastro-oesophageal reflux disease subjects was significantly different from that in controls and in some instances the distributions detected significant differences that were not detected by integrated acidity. Proton-pump inhibitor treatment significantly altered the distribution of gastric pH values and the nature of this alteration during the postprandial period was different from that during the nocturnal period. Using time pH< or =4 can significantly underestimate the magnitude of inhibition of gastric acidity caused by a proton-pump inhibitor.

CONCLUSIONS

The distribution of gastric pH values provides a rationale for selecting a particular pH value to assess gastric acidity. In some instances, the distribution of gastric pH values detects significant differences between gastro-oesophageal reflux disease and normal subjects that are not detected by integrated acidity.

Authors+Show Affiliations

Science for Organizations, Inc., Chatham, NJ 07928, USA. gardnerj@scifororg.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15606401

Citation

Gardner, J D., et al. "Frequency Analyses of Gastric pH in Control and Gastro-oesophageal Reflux Disease Subjects Treated With a Proton-pump Inhibitor." Alimentary Pharmacology & Therapeutics, vol. 20, no. 11-12, 2004, pp. 1381-6.
Gardner JD, Sloan S, Robinson M, et al. Frequency analyses of gastric pH in control and gastro-oesophageal reflux disease subjects treated with a proton-pump inhibitor. Aliment Pharmacol Ther. 2004;20(11-12):1381-6.
Gardner, J. D., Sloan, S., Robinson, M., & Miner, P. B. (2004). Frequency analyses of gastric pH in control and gastro-oesophageal reflux disease subjects treated with a proton-pump inhibitor. Alimentary Pharmacology & Therapeutics, 20(11-12), pp. 1381-6.
Gardner JD, et al. Frequency Analyses of Gastric pH in Control and Gastro-oesophageal Reflux Disease Subjects Treated With a Proton-pump Inhibitor. Aliment Pharmacol Ther. 2004;20(11-12):1381-6. PubMed PMID: 15606401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency analyses of gastric pH in control and gastro-oesophageal reflux disease subjects treated with a proton-pump inhibitor. AU - Gardner,J D, AU - Sloan,S, AU - Robinson,M, AU - Miner,P B,Jr PY - 2004/12/21/pubmed PY - 2005/6/4/medline PY - 2004/12/21/entrez SP - 1381 EP - 6 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 20 IS - 11-12 N2 - BACKGROUND: We are unaware of any solid theoretical or pathophysiological basis for selecting pH 4 or any other pH value to assess gastric acidity. AIM: To examine the frequency of different gastric pH values in control and GERD subjects. METHODS: Gastric pH was measured for 24 h in 26 control subjects, 26 gastro-oesophageal reflux disease subjects at baseline and the same 26 gastro-oesophageal reflux disease subjects during treatment with a proton-pump inhibitor. Histograms were constructed using the 21 600 values generated from each recording and bins of 0.25 pH units. RESULTS: The distribution of gastric pH values in gastro-oesophageal reflux disease subjects was significantly different from that in controls and in some instances the distributions detected significant differences that were not detected by integrated acidity. Proton-pump inhibitor treatment significantly altered the distribution of gastric pH values and the nature of this alteration during the postprandial period was different from that during the nocturnal period. Using time pH< or =4 can significantly underestimate the magnitude of inhibition of gastric acidity caused by a proton-pump inhibitor. CONCLUSIONS: The distribution of gastric pH values provides a rationale for selecting a particular pH value to assess gastric acidity. In some instances, the distribution of gastric pH values detects significant differences between gastro-oesophageal reflux disease and normal subjects that are not detected by integrated acidity. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15606401/Frequency_analyses_of_gastric_pH_in_control_and_gastro_oesophageal_reflux_disease_subjects_treated_with_a_proton_pump_inhibitor_ L2 - https://doi.org/10.1111/j.1365-2036.2004.02279.x DB - PRIME DP - Unbound Medicine ER -