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Diabetic retinopathy screening using digital non-mydriatic fundus photography and automated image analysis.
Acta Ophthalmol Scand. 2004 Dec; 82(6):666-72.AO

Abstract

PURPOSE

To investigate the use of automated image analysis for the detection of diabetic retinopathy (DR) in fundus photographs captured with and without pharmacological pupil dilation using a digital non-mydriatic camera.

METHODS

A total of 83 patients (165 eyes) with type 1 or type 2 diabetes, representing the full spectrum of DR, were photographed with and without pharmacological pupil dilation using a digital non-mydriatic camera. Two sets of five overlapping, non-stereoscopic, 45-degree field images of each eye were obtained. All images were graded in a masked fashion by two readers according to ETDRS standards and disagreements were settled by an independent adjudicator. Automated detection of red lesions as well as image quality control was made: detection of a single red lesion or insufficient image quality was categorized as possible DR.

RESULTS

At patient level, the automated red lesion detection and image quality control combined demonstrated a sensitivity of 89.9% and specificity of 85.7% in detecting DR when used on images captured without pupil dilation, and a sensitivity of 97.0% and specificity of 75.0% when used on images captured with pupil dilation. For moderate non-proliferative or more severe DR the sensitivity was 100% for images captured both with and without pupil dilation.

CONCLUSION

Our results demonstrate that the described automated image analysis system, which detects the presence or absence of DR, can be used as a first-step screening tool in DR screening with considerable effectiveness.

Authors+Show Affiliations

Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark. anbha@herlevhosp.kbhamt.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15606461

Citation

Hansen, Anja B., et al. "Diabetic Retinopathy Screening Using Digital Non-mydriatic Fundus Photography and Automated Image Analysis." Acta Ophthalmologica Scandinavica, vol. 82, no. 6, 2004, pp. 666-72.
Hansen AB, Hartvig NV, Jensen MS, et al. Diabetic retinopathy screening using digital non-mydriatic fundus photography and automated image analysis. Acta Ophthalmol Scand. 2004;82(6):666-72.
Hansen, A. B., Hartvig, N. V., Jensen, M. S., Borch-Johnsen, K., Lund-Andersen, H., & Larsen, M. (2004). Diabetic retinopathy screening using digital non-mydriatic fundus photography and automated image analysis. Acta Ophthalmologica Scandinavica, 82(6), 666-72.
Hansen AB, et al. Diabetic Retinopathy Screening Using Digital Non-mydriatic Fundus Photography and Automated Image Analysis. Acta Ophthalmol Scand. 2004;82(6):666-72. PubMed PMID: 15606461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic retinopathy screening using digital non-mydriatic fundus photography and automated image analysis. AU - Hansen,Anja B, AU - Hartvig,Niels V, AU - Jensen,Maja S, AU - Borch-Johnsen,Knut, AU - Lund-Andersen,Henrik, AU - Larsen,Michael, PY - 2004/12/21/pubmed PY - 2005/3/1/medline PY - 2004/12/21/entrez SP - 666 EP - 72 JF - Acta ophthalmologica Scandinavica JO - Acta Ophthalmol Scand VL - 82 IS - 6 N2 - PURPOSE: To investigate the use of automated image analysis for the detection of diabetic retinopathy (DR) in fundus photographs captured with and without pharmacological pupil dilation using a digital non-mydriatic camera. METHODS: A total of 83 patients (165 eyes) with type 1 or type 2 diabetes, representing the full spectrum of DR, were photographed with and without pharmacological pupil dilation using a digital non-mydriatic camera. Two sets of five overlapping, non-stereoscopic, 45-degree field images of each eye were obtained. All images were graded in a masked fashion by two readers according to ETDRS standards and disagreements were settled by an independent adjudicator. Automated detection of red lesions as well as image quality control was made: detection of a single red lesion or insufficient image quality was categorized as possible DR. RESULTS: At patient level, the automated red lesion detection and image quality control combined demonstrated a sensitivity of 89.9% and specificity of 85.7% in detecting DR when used on images captured without pupil dilation, and a sensitivity of 97.0% and specificity of 75.0% when used on images captured with pupil dilation. For moderate non-proliferative or more severe DR the sensitivity was 100% for images captured both with and without pupil dilation. CONCLUSION: Our results demonstrate that the described automated image analysis system, which detects the presence or absence of DR, can be used as a first-step screening tool in DR screening with considerable effectiveness. SN - 1395-3907 UR - https://www.unboundmedicine.com/medline/citation/15606461/Diabetic_retinopathy_screening_using_digital_non_mydriatic_fundus_photography_and_automated_image_analysis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1395-3907&date=2004&volume=82&issue=6&spage=666 DB - PRIME DP - Unbound Medicine ER -