Tags

Type your tag names separated by a space and hit enter

A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients.
Acta Ophthalmol Scand 2004; 82(6):730-7AO

Abstract

PURPOSE

To evaluate the effects of dorzolamide/timolol fixed combination (D/T) compared to latanoprost on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in primary open-angle glaucoma (POAG) patients.

METHODS

Thirty patients with POAG were randomized in an open-label, cross-over study. Intraocular pressure reduction was achieved by 4 weeks medical therapy with D/T twice daily or latanoprost 0.005% dosed once in the evening. During a 4-week run-in and a 4-week wash-out period between study arms, patients ceased use of all other glaucoma medications and used timolol maleate 0.5% twice daily. Primary efficacy variables were IOP and POBF.

RESULTS

There was no difference in baseline IOP and POBF parameters between the two study arms. Both D/T and latanoprost statistically significantly reduced IOP by 4.6 mmHg (p < 0.0001) and 3.75 mmHg (p < 0.0001) and increased POBF by 2.048 microl/second (p = 0.0030) and 2.147 microl/second (p = 0.0009), respectively. Repeated measures anova detected significant changes in POBF with treatment (p = 0.0361). Dorzolamide/timolol fixed combination statistically significantly increased pulse volume by 0.767 microl (p = 0.0087), while latanoprost therapy had no significant effect (p = 0.2407).

CONCLUSIONS

Both drugs had similar effects in terms of IOP reduction. Dorzolamide/timolol significantly increased pulse volume while latanoprost had no effect. Further studies are necessary to establish whether the enhancement of choroidal blood flow can prevent glaucoma progression.

Authors+Show Affiliations

Eye Clinic of Kaunas University of Medicine, Kaunas, Lithuania. ingrida@kmu.ltNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15606472

Citation

Janulevicienë, I, et al. "A Comparison of the Effects of Dorzolamide/timolol Fixed Combination Versus Latanoprost On Intraocular Pressure and Pulsatile Ocular Blood Flow in Primary Open-angle Glaucoma Patients." Acta Ophthalmologica Scandinavica, vol. 82, no. 6, 2004, pp. 730-7.
Janulevicienë I, Harris A, Kagemann L, et al. A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients. Acta Ophthalmol Scand. 2004;82(6):730-7.
Janulevicienë, I., Harris, A., Kagemann, L., Siesky, B., & McCranor, L. (2004). A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients. Acta Ophthalmologica Scandinavica, 82(6), pp. 730-7.
Janulevicienë I, et al. A Comparison of the Effects of Dorzolamide/timolol Fixed Combination Versus Latanoprost On Intraocular Pressure and Pulsatile Ocular Blood Flow in Primary Open-angle Glaucoma Patients. Acta Ophthalmol Scand. 2004;82(6):730-7. PubMed PMID: 15606472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients. AU - Janulevicienë,I, AU - Harris,A, AU - Kagemann,L, AU - Siesky,B, AU - McCranor,L, PY - 2004/12/21/pubmed PY - 2005/3/1/medline PY - 2004/12/21/entrez SP - 730 EP - 7 JF - Acta ophthalmologica Scandinavica JO - Acta Ophthalmol Scand VL - 82 IS - 6 N2 - PURPOSE: To evaluate the effects of dorzolamide/timolol fixed combination (D/T) compared to latanoprost on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in primary open-angle glaucoma (POAG) patients. METHODS: Thirty patients with POAG were randomized in an open-label, cross-over study. Intraocular pressure reduction was achieved by 4 weeks medical therapy with D/T twice daily or latanoprost 0.005% dosed once in the evening. During a 4-week run-in and a 4-week wash-out period between study arms, patients ceased use of all other glaucoma medications and used timolol maleate 0.5% twice daily. Primary efficacy variables were IOP and POBF. RESULTS: There was no difference in baseline IOP and POBF parameters between the two study arms. Both D/T and latanoprost statistically significantly reduced IOP by 4.6 mmHg (p < 0.0001) and 3.75 mmHg (p < 0.0001) and increased POBF by 2.048 microl/second (p = 0.0030) and 2.147 microl/second (p = 0.0009), respectively. Repeated measures anova detected significant changes in POBF with treatment (p = 0.0361). Dorzolamide/timolol fixed combination statistically significantly increased pulse volume by 0.767 microl (p = 0.0087), while latanoprost therapy had no significant effect (p = 0.2407). CONCLUSIONS: Both drugs had similar effects in terms of IOP reduction. Dorzolamide/timolol significantly increased pulse volume while latanoprost had no effect. Further studies are necessary to establish whether the enhancement of choroidal blood flow can prevent glaucoma progression. SN - 1395-3907 UR - https://www.unboundmedicine.com/medline/citation/15606472/A_comparison_of_the_effects_of_dorzolamide/timolol_fixed_combination_versus_latanoprost_on_intraocular_pressure_and_pulsatile_ocular_blood_flow_in_primary_open_angle_glaucoma_patients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1395-3907&amp;date=2004&amp;volume=82&amp;issue=6&amp;spage=730 DB - PRIME DP - Unbound Medicine ER -