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Efficacy of oral vaccination in the final stage of fox rabies elimination in Switzerland.
J Vet Med B Infect Dis Vet Public Health. 2004 Dec; 51(10):433-7.JV

Abstract

Subsequent to rabies vaccination campaigns, two well-established methods for the determination of the proportion of vaccinated foxes--the detection of tetracycline (TC) in bones and the detection of virus neutralizing antibodies (VNA) in thoracic fluids--were used and compared. Special emphasis was given to the effect of a new method of bait distribution at the den, which is primarily targeted at young foxes. The overall proportion of vaccinated animals estimated by TC was 60% as compared to 50% by VNA. In young foxes overall, significantly lower proportions of vaccinated animals (58% by TC and 40% by VNA) than in adult foxes (75 and 59%) were estimated with both methods. Low proportions of vaccinated young animals were found after spring (39 and 18%), but also after autumn vaccination (56 and 35%). In contrast, after den vaccination the level of vaccination of young foxes reached that of adult foxes. The theoretical implication of the successful elimination of fox rabies in Switzerland in spite of a relatively low overall proportion of VNA-positive animals is discussed.

Authors+Show Affiliations

Institute of Cell Biology, Swiss Federal Institute of Technology, Zürich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15606866

Citation

Bugnon, P, et al. "Efficacy of Oral Vaccination in the Final Stage of Fox Rabies Elimination in Switzerland." Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health, vol. 51, no. 10, 2004, pp. 433-7.
Bugnon P, Breitenmoser U, Peterhans E, et al. Efficacy of oral vaccination in the final stage of fox rabies elimination in Switzerland. J Vet Med B Infect Dis Vet Public Health. 2004;51(10):433-7.
Bugnon, P., Breitenmoser, U., Peterhans, E., & Zanoni, R. (2004). Efficacy of oral vaccination in the final stage of fox rabies elimination in Switzerland. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health, 51(10), 433-7.
Bugnon P, et al. Efficacy of Oral Vaccination in the Final Stage of Fox Rabies Elimination in Switzerland. J Vet Med B Infect Dis Vet Public Health. 2004;51(10):433-7. PubMed PMID: 15606866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of oral vaccination in the final stage of fox rabies elimination in Switzerland. AU - Bugnon,P, AU - Breitenmoser,U, AU - Peterhans,E, AU - Zanoni,R, PY - 2004/12/21/pubmed PY - 2005/2/12/medline PY - 2004/12/21/entrez SP - 433 EP - 7 JF - Journal of veterinary medicine. B, Infectious diseases and veterinary public health JO - J Vet Med B Infect Dis Vet Public Health VL - 51 IS - 10 N2 - Subsequent to rabies vaccination campaigns, two well-established methods for the determination of the proportion of vaccinated foxes--the detection of tetracycline (TC) in bones and the detection of virus neutralizing antibodies (VNA) in thoracic fluids--were used and compared. Special emphasis was given to the effect of a new method of bait distribution at the den, which is primarily targeted at young foxes. The overall proportion of vaccinated animals estimated by TC was 60% as compared to 50% by VNA. In young foxes overall, significantly lower proportions of vaccinated animals (58% by TC and 40% by VNA) than in adult foxes (75 and 59%) were estimated with both methods. Low proportions of vaccinated young animals were found after spring (39 and 18%), but also after autumn vaccination (56 and 35%). In contrast, after den vaccination the level of vaccination of young foxes reached that of adult foxes. The theoretical implication of the successful elimination of fox rabies in Switzerland in spite of a relatively low overall proportion of VNA-positive animals is discussed. SN - 0931-1793 UR - https://www.unboundmedicine.com/medline/citation/15606866/Efficacy_of_oral_vaccination_in_the_final_stage_of_fox_rabies_elimination_in_Switzerland_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0931-1793&date=2004&volume=51&issue=10&spage=433 DB - PRIME DP - Unbound Medicine ER -