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Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa.
Trans R Soc Trop Med Hyg. 2005 Feb; 99(2):91-100.TR

Abstract

Controversy exists about which antimalarial chemoprophylaxis regimen should be used among travellers to Africa: the WHO and other experts recommend the use of mefloquine throughout sub-Saharan Africa, whereas French experts still support the combination of chloroquine and proguanil in most of West Africa (the so-called zone 2 countries). In this case-control study based at a travel clinic, we examined the compliance with antimalarial chemoprophylaxis and its efficacy among travellers to tropical areas. Cases were patients with Plasmodium falciparum malaria (n = 131). Controls were patients who had a negative malaria film (n = 158). Of all controls, only 36 (22.8%) were adequately protected (i.e. compliant with an adapted regimen of chemoprophylaxis). In zone 2 countries, the efficacy of the combined chloroquine and proguanil was 58% (95% CI 22-78%) for all users, but increased to 100% (95% CI 89-100%) for compliant users. In zone 3 countries, the efficacy of mefloquine was 90% (95% CI 51-98%) and 100% (95% CI 58-100%) for all users and compliant users, respectively.

Authors+Show Affiliations

Unité d'Epidémiologie des Maladies Emergentes, Institut Pasteur, 28, rue du Docteur Roux, Paris 75015, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15607335

Citation

Fontanet, Arnaud L., et al. "Efficacy of Antimalarial Chemoprophylaxis Among French Residents Travelling to Africa." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 99, no. 2, 2005, pp. 91-100.
Fontanet AL, Houzé S, Keundjian A, et al. Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa. Trans R Soc Trop Med Hyg. 2005;99(2):91-100.
Fontanet, A. L., Houzé, S., Keundjian, A., Schiemann, R., Ralaimazava, P., Durand, R., Cha, O., Coulaud, J. P., Le Bras, J., & Bouchaud, O. (2005). Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99(2), 91-100.
Fontanet AL, et al. Efficacy of Antimalarial Chemoprophylaxis Among French Residents Travelling to Africa. Trans R Soc Trop Med Hyg. 2005;99(2):91-100. PubMed PMID: 15607335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa. AU - Fontanet,Arnaud L, AU - Houzé,Sandrine, AU - Keundjian,Annick, AU - Schiemann,Ricarda, AU - Ralaimazava,Pascal, AU - Durand,Rémy, AU - Cha,Olivier, AU - Coulaud,Jean-Pierre, AU - Le Bras,Jacques, AU - Bouchaud,Olivier, PY - 2003/07/30/received PY - 2003/08/01/revised PY - 2004/01/08/accepted PY - 2004/12/21/pubmed PY - 2005/5/13/medline PY - 2004/12/21/entrez SP - 91 EP - 100 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 99 IS - 2 N2 - Controversy exists about which antimalarial chemoprophylaxis regimen should be used among travellers to Africa: the WHO and other experts recommend the use of mefloquine throughout sub-Saharan Africa, whereas French experts still support the combination of chloroquine and proguanil in most of West Africa (the so-called zone 2 countries). In this case-control study based at a travel clinic, we examined the compliance with antimalarial chemoprophylaxis and its efficacy among travellers to tropical areas. Cases were patients with Plasmodium falciparum malaria (n = 131). Controls were patients who had a negative malaria film (n = 158). Of all controls, only 36 (22.8%) were adequately protected (i.e. compliant with an adapted regimen of chemoprophylaxis). In zone 2 countries, the efficacy of the combined chloroquine and proguanil was 58% (95% CI 22-78%) for all users, but increased to 100% (95% CI 89-100%) for compliant users. In zone 3 countries, the efficacy of mefloquine was 90% (95% CI 51-98%) and 100% (95% CI 58-100%) for all users and compliant users, respectively. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/15607335/Efficacy_of_antimalarial_chemoprophylaxis_among_French_residents_travelling_to_Africa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035920304001324 DB - PRIME DP - Unbound Medicine ER -