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Is hypertension an inflammatory disease?
Med Hypotheses 2005; 64(2):236-40MH

Abstract

Hypertension has been recognized as a multi-factorial trait resulting from the effect of a combination of environmental and genetic factors, including excess dietary salt or alcohol intake, stress, age, genetics and family history, obesity, physical inactivity, as well as high saturated fat diet. During the past few years, however, a large amount of information has been collected on the vascular inflammation, indicating that inflammation may involve in the initiation as well as development of hypertension and allowing us to reconsidering the pathogenic mechanisms of hypertension. Evidence from animal models as well as patients, have indicated that hypertension, an established major risk factor for coronary artery disease, has been suggested to exert pro-inflammatory actions through the increased expression of several mediators, including leukocyte adhesion molecules, chemokines, specific growth factors, heat shock proteins, endothelin-1, and angiotensin. The association between inflammation and hypertension recalls also a similar association between low-grade inflammation and other components of the metabolic syndrome, and endothelial dysfunction as well as increased serum levels of C-reactive protein in patients with hypertension. Is hypertension an inflammatory disease? This question has stimulated research on the role of vascular inflammation in hypertension. A better understanding of the inflammatory mechanism in hypertension may, therefore, contribute to novel therapeutic strategies to decrease the morbidity as well as mortality of hypertension, and alleviated hypertensive target organ damage.

Authors+Show Affiliations

Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, People's Republic of China. lijnjn@yahoo.com.cnNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15607546

Citation

Li, Jian-Jun, et al. "Is Hypertension an Inflammatory Disease?" Medical Hypotheses, vol. 64, no. 2, 2005, pp. 236-40.
Li JJ, Fang CH, Hui RT. Is hypertension an inflammatory disease? Med Hypotheses. 2005;64(2):236-40.
Li, J. J., Fang, C. H., & Hui, R. T. (2005). Is hypertension an inflammatory disease? Medical Hypotheses, 64(2), pp. 236-40.
Li JJ, Fang CH, Hui RT. Is Hypertension an Inflammatory Disease. Med Hypotheses. 2005;64(2):236-40. PubMed PMID: 15607546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is hypertension an inflammatory disease? AU - Li,Jian-Jun, AU - Fang,Chun-Hong, AU - Hui,Rui-Tai, PY - 2004/05/25/received PY - 2004/06/02/accepted PY - 2004/12/21/pubmed PY - 2005/3/30/medline PY - 2004/12/21/entrez SP - 236 EP - 40 JF - Medical hypotheses JO - Med. Hypotheses VL - 64 IS - 2 N2 - Hypertension has been recognized as a multi-factorial trait resulting from the effect of a combination of environmental and genetic factors, including excess dietary salt or alcohol intake, stress, age, genetics and family history, obesity, physical inactivity, as well as high saturated fat diet. During the past few years, however, a large amount of information has been collected on the vascular inflammation, indicating that inflammation may involve in the initiation as well as development of hypertension and allowing us to reconsidering the pathogenic mechanisms of hypertension. Evidence from animal models as well as patients, have indicated that hypertension, an established major risk factor for coronary artery disease, has been suggested to exert pro-inflammatory actions through the increased expression of several mediators, including leukocyte adhesion molecules, chemokines, specific growth factors, heat shock proteins, endothelin-1, and angiotensin. The association between inflammation and hypertension recalls also a similar association between low-grade inflammation and other components of the metabolic syndrome, and endothelial dysfunction as well as increased serum levels of C-reactive protein in patients with hypertension. Is hypertension an inflammatory disease? This question has stimulated research on the role of vascular inflammation in hypertension. A better understanding of the inflammatory mechanism in hypertension may, therefore, contribute to novel therapeutic strategies to decrease the morbidity as well as mortality of hypertension, and alleviated hypertensive target organ damage. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/15607546/Is_hypertension_an_inflammatory_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(04)00396-2 DB - PRIME DP - Unbound Medicine ER -