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Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency.
Med Hypotheses 2005; 64(2):316-7MH

Abstract

The association between liver cirrhosis and variations of glucose tolerance has been extensively documented and discussed. Zinc is an essential trace element necessary for normal protein metabolism, for the function of more than 200 zinc metalloenzymes, and for a host of physiologic functions. A poor zinc status is common in both liver cirrhosis and diabetes mellitus. Many of the clinical features of liver cirrhosis and diabetes mellitus have been linked to zinc deficiency. Zinc supplementation improved in patients with liver cirrhosis and hepatic encephalopathy with and without diabetes mellitus neurological symptoms and signs of malnutrition. Furthermore, zinc supplementation increased glucose disposal. Summarising these facts, we hypothesise that zinc deficiency is a link between liver cirrhosis and the "liver" diabetes mellitus.

Authors+Show Affiliations

dr.kgruengreiff@t-online.deNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15607563

Citation

Grüngreiff, Kurt, and Dirk Reinhold. "Liver Cirrhosis and "liver" Diabetes Mellitus Are Linked By Zinc Deficiency." Medical Hypotheses, vol. 64, no. 2, 2005, pp. 316-7.
Grüngreiff K, Reinhold D. Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency. Med Hypotheses. 2005;64(2):316-7.
Grüngreiff, K., & Reinhold, D. (2005). Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency. Medical Hypotheses, 64(2), pp. 316-7.
Grüngreiff K, Reinhold D. Liver Cirrhosis and "liver" Diabetes Mellitus Are Linked By Zinc Deficiency. Med Hypotheses. 2005;64(2):316-7. PubMed PMID: 15607563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver cirrhosis and "liver" diabetes mellitus are linked by zinc deficiency. AU - Grüngreiff,Kurt, AU - Reinhold,Dirk, PY - 2003/08/08/received PY - 2004/04/05/accepted PY - 2004/12/21/pubmed PY - 2005/3/30/medline PY - 2004/12/21/entrez SP - 316 EP - 7 JF - Medical hypotheses JO - Med. Hypotheses VL - 64 IS - 2 N2 - The association between liver cirrhosis and variations of glucose tolerance has been extensively documented and discussed. Zinc is an essential trace element necessary for normal protein metabolism, for the function of more than 200 zinc metalloenzymes, and for a host of physiologic functions. A poor zinc status is common in both liver cirrhosis and diabetes mellitus. Many of the clinical features of liver cirrhosis and diabetes mellitus have been linked to zinc deficiency. Zinc supplementation improved in patients with liver cirrhosis and hepatic encephalopathy with and without diabetes mellitus neurological symptoms and signs of malnutrition. Furthermore, zinc supplementation increased glucose disposal. Summarising these facts, we hypothesise that zinc deficiency is a link between liver cirrhosis and the "liver" diabetes mellitus. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/15607563/Liver_cirrhosis_and_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(04)00427-X DB - PRIME DP - Unbound Medicine ER -