Tags

Type your tag names separated by a space and hit enter

Treatment of electrical status epilepticus during slow-wave sleep with high-dose corticosteroid.
Pediatr Neurol. 2005 Jan; 32(1):64-7.PN

Abstract

A 4-year-old female patient with epilepsy with continuous spike-and-waves during slow-wave sleep not classified as Landau-Klefner syndrome, refractory to antiepileptic drugs including valproate, benzodiazepines, and lamotrigine, was treated successfully with high-dose intravenous methylprednisolone therapy. Valproate, clobazam, and lamotrigine were continued at the same dose during and after high-dose intravenous corticosteroid therapy. During corticosteroid therapy, awake and sleep electroencephalogram was recorded every day. On day 7, a dramatic clinical and electroencephalographic response was observed. After high-dose intravenous methylprednisolone, prednisolone was administered orally (2 mg/kg daily) for 2 months, then gradually withdrawn. After the withdrawal of corticosteroid therapy, the patient maintained the clinical improvement in behavior, and no continuous spike-and-wave electrical status epilepticus during slow-wave sleep occurred on routine monthly sleep electroencephalogram performed for the last 6 months. In the present case, an add-on high-dose intravenous corticosteroid seems to be effective in the treatment of patients with electrical status epilepticus during slow-wave sleep syndrome, especially when antiepileptic drugs fail.

Authors+Show Affiliations

Department of Pediatric Neurology, Mersin University Medical Faculty, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15607609

Citation

Okuyaz, Cetin, et al. "Treatment of Electrical Status Epilepticus During Slow-wave Sleep With High-dose Corticosteroid." Pediatric Neurology, vol. 32, no. 1, 2005, pp. 64-7.
Okuyaz C, Aydin K, Gücüyener K, et al. Treatment of electrical status epilepticus during slow-wave sleep with high-dose corticosteroid. Pediatr Neurol. 2005;32(1):64-7.
Okuyaz, C., Aydin, K., Gücüyener, K., & Serdaroğlu, A. (2005). Treatment of electrical status epilepticus during slow-wave sleep with high-dose corticosteroid. Pediatric Neurology, 32(1), 64-7.
Okuyaz C, et al. Treatment of Electrical Status Epilepticus During Slow-wave Sleep With High-dose Corticosteroid. Pediatr Neurol. 2005;32(1):64-7. PubMed PMID: 15607609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of electrical status epilepticus during slow-wave sleep with high-dose corticosteroid. AU - Okuyaz,Cetin, AU - Aydin,Kürşad, AU - Gücüyener,Kivilcim, AU - Serdaroğlu,Ayşe, PY - 2004/02/16/received PY - 2004/06/15/accepted PY - 2004/12/21/pubmed PY - 2005/2/26/medline PY - 2004/12/21/entrez SP - 64 EP - 7 JF - Pediatric neurology JO - Pediatr Neurol VL - 32 IS - 1 N2 - A 4-year-old female patient with epilepsy with continuous spike-and-waves during slow-wave sleep not classified as Landau-Klefner syndrome, refractory to antiepileptic drugs including valproate, benzodiazepines, and lamotrigine, was treated successfully with high-dose intravenous methylprednisolone therapy. Valproate, clobazam, and lamotrigine were continued at the same dose during and after high-dose intravenous corticosteroid therapy. During corticosteroid therapy, awake and sleep electroencephalogram was recorded every day. On day 7, a dramatic clinical and electroencephalographic response was observed. After high-dose intravenous methylprednisolone, prednisolone was administered orally (2 mg/kg daily) for 2 months, then gradually withdrawn. After the withdrawal of corticosteroid therapy, the patient maintained the clinical improvement in behavior, and no continuous spike-and-wave electrical status epilepticus during slow-wave sleep occurred on routine monthly sleep electroencephalogram performed for the last 6 months. In the present case, an add-on high-dose intravenous corticosteroid seems to be effective in the treatment of patients with electrical status epilepticus during slow-wave sleep syndrome, especially when antiepileptic drugs fail. SN - 0887-8994 UR - https://www.unboundmedicine.com/medline/citation/15607609/Treatment_of_electrical_status_epilepticus_during_slow_wave_sleep_with_high_dose_corticosteroid_ DB - PRIME DP - Unbound Medicine ER -