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Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection.

Abstract

In recent years, a number of newer designer drugs have entered the illicit drug market. The methylenedioxy-derivates of amphetamine represent the largest group of designer drugs. This paper describes a method for screening for and quantification of ten 2,5-methylenedioxy-derivates of amphetamine and phenylethylamine in human urine, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validates according to international guidelines.

Authors+Show Affiliations

Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Italy. gboatto@uniss.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

15607712

Citation

Boatto, Gianpiero, et al. "Determination of Amphetamine-derived Designer Drugs in Human Urine By SPE Extraction and Capillary Electrophoresis With Mass Spectrometry Detection." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 814, no. 1, 2005, pp. 93-8.
Boatto G, Nieddu M, Carta A, et al. Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;814(1):93-8.
Boatto, G., Nieddu, M., Carta, A., Pau, A., Palomba, M., Asproni, B., & Cerri, R. (2005). Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 814(1), 93-8.
Boatto G, et al. Determination of Amphetamine-derived Designer Drugs in Human Urine By SPE Extraction and Capillary Electrophoresis With Mass Spectrometry Detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 5;814(1):93-8. PubMed PMID: 15607712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection. AU - Boatto,Gianpiero, AU - Nieddu,Maria, AU - Carta,Antonio, AU - Pau,Amedeo, AU - Palomba,Michele, AU - Asproni,Battistina, AU - Cerri,Riccardo, PY - 2004/06/25/received PY - 2004/10/04/accepted PY - 2004/12/21/pubmed PY - 2005/5/21/medline PY - 2004/12/21/entrez SP - 93 EP - 8 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 814 IS - 1 N2 - In recent years, a number of newer designer drugs have entered the illicit drug market. The methylenedioxy-derivates of amphetamine represent the largest group of designer drugs. This paper describes a method for screening for and quantification of ten 2,5-methylenedioxy-derivates of amphetamine and phenylethylamine in human urine, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validates according to international guidelines. SN - 1570-0232 UR - https://www.unboundmedicine.com/medline/citation/15607712/Determination_of_amphetamine_derived_designer_drugs_in_human_urine_by_SPE_extraction_and_capillary_electrophoresis_with_mass_spectrometry_detection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(04)00803-7 DB - PRIME DP - Unbound Medicine ER -