Tags

Type your tag names separated by a space and hit enter

Disturbances of the parasympathetic branch of the autonomic nervous system in patients with gastroesophageal reflux disease (GERD) estimated by short-term heart rate variability recordings.
J Physiol Pharmacol. 2004 Jul; 55 Suppl 2:77-90.JP

Abstract

Gastro-esophageal reflux disease (GERD) is the result of the acid contents regurgitation back from the stomach into the esophagus. According to the endoscopic findings, GERD can be divided into two main forms: non-erosive (NERD) and erosive reflux esophagitis. The pathogenesis of GERD is associated with the impaired function of the antireflux barrier. Disturbances of the autonomic nervous system (ANS), especially parasympathetic part of the ANS, may be also involved in the pathogenesis of this disease. The aim of our study was to establish the parasympathetic activity in patients with reflux esophagitis and in patients with symptomatic endoscopically negative reflux. Working hypothesis was the question, whether the possible parasympathetic activity disturbances, which are observed in all GERD patients, may be regarded as the primary or secondary to the esophagitis. All the participants (20 pts. with NERD, 20 pts. with reflux esophagitis and 20 healthy controls) underwent esophageal manometry, 24-hour ambulatory pH-monitoring, resting heart rate variability (HRV) recording and the deep breathing (DB) test with the continuous HRV recording. The results of the spectral analysis both of the short-term, resting HRV recordings and DB-evoked revealed the disturbances of the main power spectra components - LF and HF in both groups of patients in comparison with the control group. In our opinion, the observed HRV spectra changes in both groups of patients support the hypothesis that not only is the parasympathetic activity impairment associated with the pathogenesis of GERD but it is also the primary factor contributing to the pathophysiological mechanism of reflux.

Authors+Show Affiliations

Department of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15608363

Citation

Dobrek, L, et al. "Disturbances of the Parasympathetic Branch of the Autonomic Nervous System in Patients With Gastroesophageal Reflux Disease (GERD) Estimated By Short-term Heart Rate Variability Recordings." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 55 Suppl 2, 2004, pp. 77-90.
Dobrek L, Nowakowski M, Mazur M, et al. Disturbances of the parasympathetic branch of the autonomic nervous system in patients with gastroesophageal reflux disease (GERD) estimated by short-term heart rate variability recordings. J Physiol Pharmacol. 2004;55 Suppl 2:77-90.
Dobrek, L., Nowakowski, M., Mazur, M., Herman, R. M., & Thor, P. J. (2004). Disturbances of the parasympathetic branch of the autonomic nervous system in patients with gastroesophageal reflux disease (GERD) estimated by short-term heart rate variability recordings. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 55 Suppl 2, 77-90.
Dobrek L, et al. Disturbances of the Parasympathetic Branch of the Autonomic Nervous System in Patients With Gastroesophageal Reflux Disease (GERD) Estimated By Short-term Heart Rate Variability Recordings. J Physiol Pharmacol. 2004;55 Suppl 2:77-90. PubMed PMID: 15608363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disturbances of the parasympathetic branch of the autonomic nervous system in patients with gastroesophageal reflux disease (GERD) estimated by short-term heart rate variability recordings. AU - Dobrek,L, AU - Nowakowski,M, AU - Mazur,M, AU - Herman,R M, AU - Thor,P J, PY - 2004/03/27/received PY - 2004/05/28/accepted PY - 2004/12/21/pubmed PY - 2008/1/18/medline PY - 2004/12/21/entrez SP - 77 EP - 90 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J. Physiol. Pharmacol. VL - 55 Suppl 2 N2 - Gastro-esophageal reflux disease (GERD) is the result of the acid contents regurgitation back from the stomach into the esophagus. According to the endoscopic findings, GERD can be divided into two main forms: non-erosive (NERD) and erosive reflux esophagitis. The pathogenesis of GERD is associated with the impaired function of the antireflux barrier. Disturbances of the autonomic nervous system (ANS), especially parasympathetic part of the ANS, may be also involved in the pathogenesis of this disease. The aim of our study was to establish the parasympathetic activity in patients with reflux esophagitis and in patients with symptomatic endoscopically negative reflux. Working hypothesis was the question, whether the possible parasympathetic activity disturbances, which are observed in all GERD patients, may be regarded as the primary or secondary to the esophagitis. All the participants (20 pts. with NERD, 20 pts. with reflux esophagitis and 20 healthy controls) underwent esophageal manometry, 24-hour ambulatory pH-monitoring, resting heart rate variability (HRV) recording and the deep breathing (DB) test with the continuous HRV recording. The results of the spectral analysis both of the short-term, resting HRV recordings and DB-evoked revealed the disturbances of the main power spectra components - LF and HF in both groups of patients in comparison with the control group. In our opinion, the observed HRV spectra changes in both groups of patients support the hypothesis that not only is the parasympathetic activity impairment associated with the pathogenesis of GERD but it is also the primary factor contributing to the pathophysiological mechanism of reflux. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/15608363/Disturbances_of_the_parasympathetic_branch_of_the_autonomic_nervous_system_in_patients_with_gastroesophageal_reflux_disease__GERD__estimated_by_short_term_heart_rate_variability_recordings_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -