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Coagulation and fibrinolysis parameters in type 2 diabetic patients with and without diabetic vascular complications.
Med Princ Pract. 2005 Jan-Feb; 14(1):22-30.MP

Abstract

OBJECTIVES

To investigate the markers of endogenous coagulation/fibrinolysis and vascular endothelial cell function, and to assess the relationships between hemostatic parameters and diabetic vascular complications in type 2 diabetic patients.

MATERIALS AND METHODS

Coagulation and fibrinolysis parameters were measured in 92 type 2 diabetic patients (43 male, 49 female, mean age 50.1 +/- 13.4 years) with (n = 44) and without (n = 48) vascular diabetic complications, and in 40 nondiabetic healthy subjects (20 male, 20 female, mean age 49.8 +/- 15.1 years). Common lipid parameters were also measured.

RESULTS

The plasma levels of fibrinogen, antithrombin III (AT III), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF) activity and prothrombin time were found to be significantly increased in the type 2 diabetic patients compared with the healthy subjects. Glycosylated hemoglobin lc was inversely correlated with plasma protein S and activated prothrombin time. Protein C and S activities were positively correlated with plasma vWF activity, and were negatively correlated with plasma t-PA levels. vWF activity was negatively correlated with plasma t-PA levels. AT III levels were positively correlated with plasma total cholesterol levels, plasma low density lipoprotein cholesterol levels, plasma triglycerides and D-dimer levels. Plasma PAI-1 levels and factor V activity in diabetic patients with microvascular complications were significantly higher than those of the diabetic patients without microvascular complications. The plasma PAI-1 and platelet count were increased in patients with diabetic retinopathy compared with the diabetic patients without retinopathy. Plasma PAI-1 levels and factor VII activity were significantly higher in the diabetic patients with nephropathy than in diabetic patients without nephropathy. Plasma concentrations of fibrinogen and PAI-1 were significantly higher in the diabetic patients with neuropathy than the diabetic patients without neuropathy.

CONCLUSIONS

The data demonstrated that patients with type 2 diabetes mellitus had a hypercoagulable state and hypofibrinolysis, thereby indicating that activation of coagulation with a reduced fibrinolytic activity may contribute to the increased risk of vascular disease in type 2 diabetic patients.

Authors+Show Affiliations

Department of Internal Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. cihangirerem@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15608477

Citation

Erem, Cihangir, et al. "Coagulation and Fibrinolysis Parameters in Type 2 Diabetic Patients With and Without Diabetic Vascular Complications." Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, vol. 14, no. 1, 2005, pp. 22-30.
Erem C, Hacihasanoğlu A, Celik S, et al. Coagulation and fibrinolysis parameters in type 2 diabetic patients with and without diabetic vascular complications. Med Princ Pract. 2005;14(1):22-30.
Erem, C., Hacihasanoğlu, A., Celik, S., Ovali, E., Ersöz, H. O., Ukinç, K., Deger, O., & Telatar, M. (2005). Coagulation and fibrinolysis parameters in type 2 diabetic patients with and without diabetic vascular complications. Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 14(1), 22-30.
Erem C, et al. Coagulation and Fibrinolysis Parameters in Type 2 Diabetic Patients With and Without Diabetic Vascular Complications. Med Princ Pract. 2005 Jan-Feb;14(1):22-30. PubMed PMID: 15608477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coagulation and fibrinolysis parameters in type 2 diabetic patients with and without diabetic vascular complications. AU - Erem,Cihangir, AU - Hacihasanoğlu,Arif, AU - Celik,Sükrü, AU - Ovali,Ercüment, AU - Ersöz,H Onder, AU - Ukinç,Kubilay, AU - Deger,Orhan, AU - Telatar,Münir, PY - 2003/07/06/received PY - 2004/02/07/accepted PY - 2004/12/21/pubmed PY - 2005/4/20/medline PY - 2004/12/21/entrez SP - 22 EP - 30 JF - Medical principles and practice : international journal of the Kuwait University, Health Science Centre JO - Med Princ Pract VL - 14 IS - 1 N2 - OBJECTIVES: To investigate the markers of endogenous coagulation/fibrinolysis and vascular endothelial cell function, and to assess the relationships between hemostatic parameters and diabetic vascular complications in type 2 diabetic patients. MATERIALS AND METHODS: Coagulation and fibrinolysis parameters were measured in 92 type 2 diabetic patients (43 male, 49 female, mean age 50.1 +/- 13.4 years) with (n = 44) and without (n = 48) vascular diabetic complications, and in 40 nondiabetic healthy subjects (20 male, 20 female, mean age 49.8 +/- 15.1 years). Common lipid parameters were also measured. RESULTS: The plasma levels of fibrinogen, antithrombin III (AT III), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF) activity and prothrombin time were found to be significantly increased in the type 2 diabetic patients compared with the healthy subjects. Glycosylated hemoglobin lc was inversely correlated with plasma protein S and activated prothrombin time. Protein C and S activities were positively correlated with plasma vWF activity, and were negatively correlated with plasma t-PA levels. vWF activity was negatively correlated with plasma t-PA levels. AT III levels were positively correlated with plasma total cholesterol levels, plasma low density lipoprotein cholesterol levels, plasma triglycerides and D-dimer levels. Plasma PAI-1 levels and factor V activity in diabetic patients with microvascular complications were significantly higher than those of the diabetic patients without microvascular complications. The plasma PAI-1 and platelet count were increased in patients with diabetic retinopathy compared with the diabetic patients without retinopathy. Plasma PAI-1 levels and factor VII activity were significantly higher in the diabetic patients with nephropathy than in diabetic patients without nephropathy. Plasma concentrations of fibrinogen and PAI-1 were significantly higher in the diabetic patients with neuropathy than the diabetic patients without neuropathy. CONCLUSIONS: The data demonstrated that patients with type 2 diabetes mellitus had a hypercoagulable state and hypofibrinolysis, thereby indicating that activation of coagulation with a reduced fibrinolytic activity may contribute to the increased risk of vascular disease in type 2 diabetic patients. SN - 1011-7571 UR - https://www.unboundmedicine.com/medline/citation/15608477/Coagulation_and_fibrinolysis_parameters_in_type_2_diabetic_patients_with_and_without_diabetic_vascular_complications_ L2 - https://www.karger.com?DOI=10.1159/000081919 DB - PRIME DP - Unbound Medicine ER -