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Insulin resistance in a rural Maori community.
N Z Med J. 2004 Dec 17; 117(1207):U1208.NZ

Abstract

AIM

To determine the prevalence of insulin resistance, impaired fasting glycaemia, impaired glucose tolerance, and diabetes mellitus in a rural Maori community, and to compare different methods for identifying individuals with insulin resistance.

METHODS

589 randomly selected individuals from the Ngati Porou Hauora Register aged 25 years and over and resident on New Zealand's East Coast north of Gisborne were invited to participate in the study. A questionnaire was administered, anthropometric measures made, and blood samples taken for an oral glucose tolerance test and biochemical analysis. Impaired fasting glycaemia, impaired glucose tolerance, and diabetes mellitus were defined according to World Health Organization (WHO) diagnostic criteria, and among those persons with normal glucose tolerance, insulin resistance was calculated according to the McAuley formula and three other recognised methods for calculating insulin sensitivity.

RESULTS

The overall age-standardised prevalence of diabetes (both known and newly diagnosed) was 10.6% and the age-standardised prevalence of insulin resistance was 37.0%. Age-specific diabetes rates were high among the older age groups, peaking at 34.1% for 60-69 year olds, whereas age-specific insulin resistance rates were high among the young age groups with the highest rate (44.3%) occurring among 30-39 year olds. Persons identifying as insulin-resistant reported higher rates of gout and family history of diabetes--and were found to have a higher waist circumference, blood pressure, and lower high-density lipoprotein (HDL) cholesterol than those without a glucose metabolism disorder.

CONCLUSION

Diabetes is a common disorder among this population, but insulin resistance is even more prevalent, especially among young age groups. This is considerable cause for concern given that insulin resistance is believed to be the underlying cause of most cases of type 2 diabetes mellitus, and is confirmed by these data to be associated with a high degree of cardiovascular risk.

Authors+Show Affiliations

Edgar National Centre for Diabetes Research, University of Otago, Dunedin, New Zealand. davidt@nph.co.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15608803

Citation

Tipene-Leach, David, et al. "Insulin Resistance in a Rural Maori Community." The New Zealand Medical Journal, vol. 117, no. 1207, 2004, pp. U1208.
Tipene-Leach D, Pahau H, Joseph N, et al. Insulin resistance in a rural Maori community. N Z Med J. 2004;117(1207):U1208.
Tipene-Leach, D., Pahau, H., Joseph, N., Coppell, K., McAuley, K., Booker, C., Williams, S., & Mann, J. (2004). Insulin resistance in a rural Maori community. The New Zealand Medical Journal, 117(1207), U1208.
Tipene-Leach D, et al. Insulin Resistance in a Rural Maori Community. N Z Med J. 2004 Dec 17;117(1207):U1208. PubMed PMID: 15608803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance in a rural Maori community. AU - Tipene-Leach,David, AU - Pahau,Helen, AU - Joseph,Nathan, AU - Coppell,Kirsten, AU - McAuley,Kirsten, AU - Booker,Chris, AU - Williams,Sheila, AU - Mann,Jim, Y1 - 2004/12/17/ PY - 2004/12/21/pubmed PY - 2005/3/25/medline PY - 2004/12/21/entrez SP - U1208 EP - U1208 JF - The New Zealand medical journal JO - N Z Med J VL - 117 IS - 1207 N2 - AIM: To determine the prevalence of insulin resistance, impaired fasting glycaemia, impaired glucose tolerance, and diabetes mellitus in a rural Maori community, and to compare different methods for identifying individuals with insulin resistance. METHODS: 589 randomly selected individuals from the Ngati Porou Hauora Register aged 25 years and over and resident on New Zealand's East Coast north of Gisborne were invited to participate in the study. A questionnaire was administered, anthropometric measures made, and blood samples taken for an oral glucose tolerance test and biochemical analysis. Impaired fasting glycaemia, impaired glucose tolerance, and diabetes mellitus were defined according to World Health Organization (WHO) diagnostic criteria, and among those persons with normal glucose tolerance, insulin resistance was calculated according to the McAuley formula and three other recognised methods for calculating insulin sensitivity. RESULTS: The overall age-standardised prevalence of diabetes (both known and newly diagnosed) was 10.6% and the age-standardised prevalence of insulin resistance was 37.0%. Age-specific diabetes rates were high among the older age groups, peaking at 34.1% for 60-69 year olds, whereas age-specific insulin resistance rates were high among the young age groups with the highest rate (44.3%) occurring among 30-39 year olds. Persons identifying as insulin-resistant reported higher rates of gout and family history of diabetes--and were found to have a higher waist circumference, blood pressure, and lower high-density lipoprotein (HDL) cholesterol than those without a glucose metabolism disorder. CONCLUSION: Diabetes is a common disorder among this population, but insulin resistance is even more prevalent, especially among young age groups. This is considerable cause for concern given that insulin resistance is believed to be the underlying cause of most cases of type 2 diabetes mellitus, and is confirmed by these data to be associated with a high degree of cardiovascular risk. SN - 1175-8716 UR - https://www.unboundmedicine.com/medline/citation/15608803/Insulin_resistance_in_a_rural_Maori_community_ L2 - https://medlineplus.gov/nativehawaiianandpacificislanderhealth.html DB - PRIME DP - Unbound Medicine ER -