Tags

Type your tag names separated by a space and hit enter

Stability study of lipoic acid in the presence of vitamins A and E in o/w emulsions for cosmetic application.
J Cosmet Sci. 2004 Sep-Oct; 55(5):449-61.JC

Abstract

The effectiveness of any cosmetic product containing a functional ingredient is determined by the skin delivery of the active molecule, which is influenced by the type of carrier and the molecule itself. Furthermore, the functional ingredient should be stable in the formulation. The purpose of this paper is to study the stability of lipoic acid in the presence of vitamins A (as palmitate) and E (as acetate) in semisolids for cosmetic use. The systems formulated were studied in regard to their aspect, pH, stability under centrifugation, and rheological behavior. The chemical analyses of lipoic acid and vitamins A and E were carried out by HPLC after studying the specificity of the method employed in each case. The quantitation of the active principles was performed by HPLC with C18 (5 microm) columns. The mobile phase was methanol for the vitamins, with spectrophotometric detection at 325 nm for vitamin A and 230 nm for vitamin E. The mobile phase for lipoic acid was methanol:water (80:20) and phosphoric acid at pH 3.0, with spectrophotometric detection at 332 nm. All systems were stable to centrifugation, and no significant modification of rheological behavior was observed in relation to the base emulsion used as control. The chemical studies performed indicated that although lipoic acid is not very stable in these formulations, the presence of vitamin A favors its chemical stability.

Authors+Show Affiliations

Department of Pharmaceutical Technology, School of Pharmacy and Biochemistry, University of Buenos Aires. Junín 956, 1113 Buenos Aires.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15608995

Citation

Segall, A, et al. "Stability Study of Lipoic Acid in the Presence of Vitamins a and E in O/w Emulsions for Cosmetic Application." Journal of Cosmetic Science, vol. 55, no. 5, 2004, pp. 449-61.
Segall A, Sosa M, Alami A, et al. Stability study of lipoic acid in the presence of vitamins A and E in o/w emulsions for cosmetic application. J Cosmet Sci. 2004;55(5):449-61.
Segall, A., Sosa, M., Alami, A., Enero, C., Hormaechea, F., Pizzorno, M. T., Bregni, C., & Serrao, R. (2004). Stability study of lipoic acid in the presence of vitamins A and E in o/w emulsions for cosmetic application. Journal of Cosmetic Science, 55(5), 449-61.
Segall A, et al. Stability Study of Lipoic Acid in the Presence of Vitamins a and E in O/w Emulsions for Cosmetic Application. J Cosmet Sci. 2004 Sep-Oct;55(5):449-61. PubMed PMID: 15608995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability study of lipoic acid in the presence of vitamins A and E in o/w emulsions for cosmetic application. AU - Segall,A, AU - Sosa,M, AU - Alami,A, AU - Enero,C, AU - Hormaechea,F, AU - Pizzorno,M T, AU - Bregni,C, AU - Serrao,R, PY - 2004/07/07/accepted PY - 2004/12/21/pubmed PY - 2005/1/12/medline PY - 2004/12/21/entrez SP - 449 EP - 61 JF - Journal of cosmetic science JO - J Cosmet Sci VL - 55 IS - 5 N2 - The effectiveness of any cosmetic product containing a functional ingredient is determined by the skin delivery of the active molecule, which is influenced by the type of carrier and the molecule itself. Furthermore, the functional ingredient should be stable in the formulation. The purpose of this paper is to study the stability of lipoic acid in the presence of vitamins A (as palmitate) and E (as acetate) in semisolids for cosmetic use. The systems formulated were studied in regard to their aspect, pH, stability under centrifugation, and rheological behavior. The chemical analyses of lipoic acid and vitamins A and E were carried out by HPLC after studying the specificity of the method employed in each case. The quantitation of the active principles was performed by HPLC with C18 (5 microm) columns. The mobile phase was methanol for the vitamins, with spectrophotometric detection at 325 nm for vitamin A and 230 nm for vitamin E. The mobile phase for lipoic acid was methanol:water (80:20) and phosphoric acid at pH 3.0, with spectrophotometric detection at 332 nm. All systems were stable to centrifugation, and no significant modification of rheological behavior was observed in relation to the base emulsion used as control. The chemical studies performed indicated that although lipoic acid is not very stable in these formulations, the presence of vitamin A favors its chemical stability. SN - 1525-7886 UR - https://www.unboundmedicine.com/medline/citation/15608995/Stability_study_of_lipoic_acid_in_the_presence_of_vitamins_A_and_E_in_o/w_emulsions_for_cosmetic_application_ L2 - https://medlineplus.gov/cosmetics.html DB - PRIME DP - Unbound Medicine ER -