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Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Int J Cancer. 2005 May 01; 114(5):824-30.IJ

Abstract

We studied the association between dietary folate and specific K-ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer. After 7.3 years of follow-up, 448 colon and 160 rectal cancer patients and 3,048 sub-cohort members (55-69 years at baseline) were available for data analyses. Mutation analysis of the K-ras gene was carried out on all archival adenocarcinoma specimens. Case-cohort analyses were used to compute adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) for colon and rectal cancer overall and for K-ras mutation status subgroups according to 100 mug/day increased intake in dietary folate. Dietary folate intake was not significantly associated with colon cancer risk for men or women, neither overall nor with K-ras mutation status. For rectal cancer, folate intake was associated with a decreased disease risk in men and was most pronounced for K-ras mutated tumors, whereas an increased association was observed for women. Regarding the K-ras mutation status in women, an increased association was observed for both wild-type and mutated K-ras tumors. Specifically, folate intake was associated with an increased risk of G>T and G>C transversions in rectal tumors (RR = 2.69, 95% CI = 1.43-5.09), but inversely associated with G>A transitions (RR = 0.08, 95% CI = 0.01-0.53). Our data suggest that the effect of folate on rectal cancer risk is different for men and women and depends on the K-ras mutation status of the tumor.

Authors+Show Affiliations

Research Institute Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15609319

Citation

Brink, Mirian, et al. "Dietary Folate Intake and K-ras Mutations in Sporadic Colon and Rectal Cancer in the Netherlands Cohort Study." International Journal of Cancer, vol. 114, no. 5, 2005, pp. 824-30.
Brink M, Weijenberg MP, de Goeij AF, et al. Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. Int J Cancer. 2005;114(5):824-30.
Brink, M., Weijenberg, M. P., de Goeij, A. F., Roemen, G. M., Lentjes, M. H., de Bruïne, A. P., van Engeland, M., Goldbohm, R. A., & van den Brandt, P. A. (2005). Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. International Journal of Cancer, 114(5), 824-30.
Brink M, et al. Dietary Folate Intake and K-ras Mutations in Sporadic Colon and Rectal Cancer in the Netherlands Cohort Study. Int J Cancer. 2005 May 1;114(5):824-30. PubMed PMID: 15609319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. AU - Brink,Mirian, AU - Weijenberg,Matty P, AU - de Goeij,Anton F P M, AU - Roemen,Guido M J M, AU - Lentjes,Marjolein H F M, AU - de Bruïne,Adriaan P, AU - van Engeland,Manon, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, PY - 2004/12/21/pubmed PY - 2005/4/14/medline PY - 2004/12/21/entrez SP - 824 EP - 30 JF - International journal of cancer JO - Int. J. Cancer VL - 114 IS - 5 N2 - We studied the association between dietary folate and specific K-ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer. After 7.3 years of follow-up, 448 colon and 160 rectal cancer patients and 3,048 sub-cohort members (55-69 years at baseline) were available for data analyses. Mutation analysis of the K-ras gene was carried out on all archival adenocarcinoma specimens. Case-cohort analyses were used to compute adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) for colon and rectal cancer overall and for K-ras mutation status subgroups according to 100 mug/day increased intake in dietary folate. Dietary folate intake was not significantly associated with colon cancer risk for men or women, neither overall nor with K-ras mutation status. For rectal cancer, folate intake was associated with a decreased disease risk in men and was most pronounced for K-ras mutated tumors, whereas an increased association was observed for women. Regarding the K-ras mutation status in women, an increased association was observed for both wild-type and mutated K-ras tumors. Specifically, folate intake was associated with an increased risk of G>T and G>C transversions in rectal tumors (RR = 2.69, 95% CI = 1.43-5.09), but inversely associated with G>A transitions (RR = 0.08, 95% CI = 0.01-0.53). Our data suggest that the effect of folate on rectal cancer risk is different for men and women and depends on the K-ras mutation status of the tumor. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/15609319/Dietary_folate_intake_and_k_ras_mutations_in_sporadic_colon_and_rectal_cancer_in_The_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1002/ijc.20775 DB - PRIME DP - Unbound Medicine ER -