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Possible relationship between Helicobacter pylori infection and cap polyposis of the colon.
Helicobacter. 2004 Dec; 9(6):651-6.H

Abstract

BACKGROUND

Cap polyposis is a rarely encountered disease characterized by multiple distinctive inflammatory colonic polyps located from the rectum to the distal colon. The etiology of this disease is still unknown, and no specific treatment has been established.

AIM

We report three cases of cap polyposis that were cured following eradication therapy for Helicobacter pylori infection.

METHODS AND RESULTS

Three women were referred to Shinshu University Hospital because of mucoid and/or bloody diarrhea. Laboratory data showed hypoproteinemia in all cases; markers of inflammation such as C-reactive protein were negative. Colonoscopy revealed multiple sessile polyps with mucus adherent on the apices of the mucosal folds in the rectum and/or the sigmoid colon. The intervening mucosa was normal. Microscopic examinations of biopsy specimens taken from sessile polyps revealed inflamed mucosa with elongated tortuous crypts attenuated towards the mucosal surface. A granulation tissue 'cap' was observed on the surface of the mucosa. Various treatments were unsuccessful, including administration of metronidazole or prednisolone, avoidance of straining at defecation, and surgical or endoscopic resection. All were diagnosed with H. pylori infection in the stomach. Helicobacter pylori was not detected in the biopsy specimens from the colonic inflammatory polyps by immunohistochemical study using polyclonal anti-H. pylori antibody. After successful eradication therapy the clinical symptoms improved. Disappearance of cap polyposis was confirmed by colonoscopy in all three cases.

CONCLUSION

We speculate that H. pylori infection might play a role in the pathogenesis of cap polyposis.

Authors+Show Affiliations

Department of Endoscopy, Shinshu University Hospital, Shinshu University School of Medicine, Matsumoto, Japan. ta07260@hsp.md.shinshu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15610079

Citation

Akamatsu, Taiji, et al. "Possible Relationship Between Helicobacter Pylori Infection and Cap Polyposis of the Colon." Helicobacter, vol. 9, no. 6, 2004, pp. 651-6.
Akamatsu T, Nakamura N, Kawamura Y, et al. Possible relationship between Helicobacter pylori infection and cap polyposis of the colon. Helicobacter. 2004;9(6):651-6.
Akamatsu, T., Nakamura, N., Kawamura, Y., Shinji, A., Tateiwa, N., Ochi, Y., Katsuyama, T., & Kiyosawa, K. (2004). Possible relationship between Helicobacter pylori infection and cap polyposis of the colon. Helicobacter, 9(6), 651-6.
Akamatsu T, et al. Possible Relationship Between Helicobacter Pylori Infection and Cap Polyposis of the Colon. Helicobacter. 2004;9(6):651-6. PubMed PMID: 15610079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible relationship between Helicobacter pylori infection and cap polyposis of the colon. AU - Akamatsu,Taiji, AU - Nakamura,Naoshi, AU - Kawamura,Yoko, AU - Shinji,Akihiro, AU - Tateiwa,Nobuyuki, AU - Ochi,Yasuhide, AU - Katsuyama,Tsutomu, AU - Kiyosawa,Kendo, PY - 2004/12/22/pubmed PY - 2005/5/17/medline PY - 2004/12/22/entrez SP - 651 EP - 6 JF - Helicobacter JO - Helicobacter VL - 9 IS - 6 N2 - BACKGROUND: Cap polyposis is a rarely encountered disease characterized by multiple distinctive inflammatory colonic polyps located from the rectum to the distal colon. The etiology of this disease is still unknown, and no specific treatment has been established. AIM: We report three cases of cap polyposis that were cured following eradication therapy for Helicobacter pylori infection. METHODS AND RESULTS: Three women were referred to Shinshu University Hospital because of mucoid and/or bloody diarrhea. Laboratory data showed hypoproteinemia in all cases; markers of inflammation such as C-reactive protein were negative. Colonoscopy revealed multiple sessile polyps with mucus adherent on the apices of the mucosal folds in the rectum and/or the sigmoid colon. The intervening mucosa was normal. Microscopic examinations of biopsy specimens taken from sessile polyps revealed inflamed mucosa with elongated tortuous crypts attenuated towards the mucosal surface. A granulation tissue 'cap' was observed on the surface of the mucosa. Various treatments were unsuccessful, including administration of metronidazole or prednisolone, avoidance of straining at defecation, and surgical or endoscopic resection. All were diagnosed with H. pylori infection in the stomach. Helicobacter pylori was not detected in the biopsy specimens from the colonic inflammatory polyps by immunohistochemical study using polyclonal anti-H. pylori antibody. After successful eradication therapy the clinical symptoms improved. Disappearance of cap polyposis was confirmed by colonoscopy in all three cases. CONCLUSION: We speculate that H. pylori infection might play a role in the pathogenesis of cap polyposis. SN - 1083-4389 UR - https://www.unboundmedicine.com/medline/citation/15610079/Possible_relationship_between_Helicobacter_pylori_infection_and_cap_polyposis_of_the_colon_ L2 - https://doi.org/10.1111/j.1083-4389.2004.00273.x DB - PRIME DP - Unbound Medicine ER -