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Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 months of age.
Pediatr Allergy Immunol. 2004 Dec; 15(6):517-22.PA

Abstract

The objective of this study was to assess the relation between observed levels of omega-3 fatty acids in plasma and symptoms of asthma and atopy in children at 18 months of age. A total of 616 women at risk of having a child who would develop asthma because of a family history were recruited from the antenatal clinics of six hospitals in Sydney, Australia. Families were randomized to either active omega-3 supplemented or control group. The active group received a daily tuna fish oil supplement and omega-3-rich margarines and cooking oils and the control group received a placebo supplement with polyunsaturated margarines and cooking oils. When the children were 18 months of age an assessment of symptoms was carried out by a research nurse blinded to treatment group allocation. Atopy was measured by skin prick tests, blood was collected to determine serum immunoglobulin E (IgE), and plasma fatty acid concentrations. A total of 376 children (61.0% of total recruited) completed an assessment at 18 months and had blood taken to determine plasma fatty acid concentrations. Omega-3 fatty acid levels were expressed in quintiles of exposure 'as treated' without reference to treatment group allocation. Wheeze ever, doctor visits for wheeze, bronchodilator use and nocturnal coughing were significantly reduced in children in the higher exposure quintiles. Serum IgE was reduced in the highest quintile but not significantly so. There was no difference in diagnosed asthma or atopy between the exposure quintiles. Although wheeze at this age may not be a good indicator of asthma in later childhood, it is encouraging that some symptoms have been reduced in children with high omega-3 fatty acid concentrations in plasma.

Authors+Show Affiliations

Clinical Epidemiology Unit, The Children's Hospital at Westmead, NSW, Australia. seemam@chw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15610365

Citation

Mihrshahi, Seema, et al. "Effect of Omega-3 Fatty Acid Concentrations in Plasma On Symptoms of Asthma at 18 Months of Age." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 15, no. 6, 2004, pp. 517-22.
Mihrshahi S, Peat JK, Webb K, et al. Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 months of age. Pediatr Allergy Immunol. 2004;15(6):517-22.
Mihrshahi, S., Peat, J. K., Webb, K., Oddy, W., Marks, G. B., & Mellis, C. M. (2004). Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 months of age. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 15(6), 517-22.
Mihrshahi S, et al. Effect of Omega-3 Fatty Acid Concentrations in Plasma On Symptoms of Asthma at 18 Months of Age. Pediatr Allergy Immunol. 2004;15(6):517-22. PubMed PMID: 15610365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 months of age. AU - Mihrshahi,Seema, AU - Peat,Jennifer K, AU - Webb,Karen, AU - Oddy,Wendy, AU - Marks,Guy B, AU - Mellis,Craig M, AU - ,, PY - 2004/12/22/pubmed PY - 2005/5/27/medline PY - 2004/12/22/entrez SP - 517 EP - 22 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 15 IS - 6 N2 - The objective of this study was to assess the relation between observed levels of omega-3 fatty acids in plasma and symptoms of asthma and atopy in children at 18 months of age. A total of 616 women at risk of having a child who would develop asthma because of a family history were recruited from the antenatal clinics of six hospitals in Sydney, Australia. Families were randomized to either active omega-3 supplemented or control group. The active group received a daily tuna fish oil supplement and omega-3-rich margarines and cooking oils and the control group received a placebo supplement with polyunsaturated margarines and cooking oils. When the children were 18 months of age an assessment of symptoms was carried out by a research nurse blinded to treatment group allocation. Atopy was measured by skin prick tests, blood was collected to determine serum immunoglobulin E (IgE), and plasma fatty acid concentrations. A total of 376 children (61.0% of total recruited) completed an assessment at 18 months and had blood taken to determine plasma fatty acid concentrations. Omega-3 fatty acid levels were expressed in quintiles of exposure 'as treated' without reference to treatment group allocation. Wheeze ever, doctor visits for wheeze, bronchodilator use and nocturnal coughing were significantly reduced in children in the higher exposure quintiles. Serum IgE was reduced in the highest quintile but not significantly so. There was no difference in diagnosed asthma or atopy between the exposure quintiles. Although wheeze at this age may not be a good indicator of asthma in later childhood, it is encouraging that some symptoms have been reduced in children with high omega-3 fatty acid concentrations in plasma. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/15610365/Effect_of_omega_3_fatty_acid_concentrations_in_plasma_on_symptoms_of_asthma_at_18_months_of_age_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0905-6157&date=2004&volume=15&issue=6&spage=517 DB - PRIME DP - Unbound Medicine ER -