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Current Treatment of Nystagmus.
Curr Treat Options Neurol. 2005 Jan; 7(1):69-77.CT

Abstract

Acquired and congenital nystagmus often causes decreased visual acuity as a direct result of the inability to maintain stable foveal vision. In addition, acquired nystagmus causes a disabling subjective sensation of movement of the visual world called oscillopsia. The eye movements themselves do not require treatment if the patient is asymptomatic. However, therapy is necessary if visual disability is present. Treatments based in pharmacologic mechanisms are preferred. There are few controlled treatment trials and therapeutic efficacy generally is sought in a trial and error approach, depending on the type of nystagmus present. Treatment with 3,4-diaminopyridine and 4-aminopyridine recently have been shown to be effective for downbeat nystagmus. Gabapentin, baclofen, and clonazepam also are useful in some patients with downbeat nystagmus. Baclofen is the therapy of choice for periodic alternating nystagmus. Gabapentin often is effective for acquired pendular nystagmus. Clonazepam and valproate also may be effective for acquired pendular nystagmus. Memantine now is available in the United States and is promising in the treatment of pendular nystagmus. Optical devices that negate the negative effects of nystagmus continue to undergo development research. These and other medical, surgical, and optical devices are potentially useful alone or in combination with other therapies.

Authors+Show Affiliations

Department of Neurology, Case Western Reserve School of Medicine, Hanna House 5th Floor, 11100 Euclid Avenue, Cleveland, OH 44106, USA. janet.rucker@uhhs.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15610709

Citation

Rucker, Janet C.. "Current Treatment of Nystagmus." Current Treatment Options in Neurology, vol. 7, no. 1, 2005, pp. 69-77.
Rucker JC. Current Treatment of Nystagmus. Curr Treat Options Neurol. 2005;7(1):69-77.
Rucker, J. C. (2005). Current Treatment of Nystagmus. Current Treatment Options in Neurology, 7(1), 69-77.
Rucker JC. Current Treatment of Nystagmus. Curr Treat Options Neurol. 2005;7(1):69-77. PubMed PMID: 15610709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current Treatment of Nystagmus. A1 - Rucker,Janet C, PY - 2004/12/22/pubmed PY - 2004/12/22/medline PY - 2004/12/22/entrez SP - 69 EP - 77 JF - Current treatment options in neurology JO - Curr Treat Options Neurol VL - 7 IS - 1 N2 - Acquired and congenital nystagmus often causes decreased visual acuity as a direct result of the inability to maintain stable foveal vision. In addition, acquired nystagmus causes a disabling subjective sensation of movement of the visual world called oscillopsia. The eye movements themselves do not require treatment if the patient is asymptomatic. However, therapy is necessary if visual disability is present. Treatments based in pharmacologic mechanisms are preferred. There are few controlled treatment trials and therapeutic efficacy generally is sought in a trial and error approach, depending on the type of nystagmus present. Treatment with 3,4-diaminopyridine and 4-aminopyridine recently have been shown to be effective for downbeat nystagmus. Gabapentin, baclofen, and clonazepam also are useful in some patients with downbeat nystagmus. Baclofen is the therapy of choice for periodic alternating nystagmus. Gabapentin often is effective for acquired pendular nystagmus. Clonazepam and valproate also may be effective for acquired pendular nystagmus. Memantine now is available in the United States and is promising in the treatment of pendular nystagmus. Optical devices that negate the negative effects of nystagmus continue to undergo development research. These and other medical, surgical, and optical devices are potentially useful alone or in combination with other therapies. SN - 1092-8480 UR - https://www.unboundmedicine.com/medline/citation/15610709/Current_Treatment_of_Nystagmus_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15610709.ui DB - PRIME DP - Unbound Medicine ER -
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