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Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships.
J Agric Food Chem. 2004 Dec 29; 52(26):7884-90.JA

Abstract

The phenolic constituents in the roots of Rheum officinale and Rubia cordifolia were identified with the aid of high-performance liquid chromatography and liquid chromatography-mass spectrometry and by comparison with authentic standards. A total of 17 hydroxyanthraquinones, gallic acid, and tannins were separated, and 14 of them were identified, being the main phenolic constituents present. Their antioxidant activity (Trolox equivalent antioxidant capacity) was evaluated using the improved 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt method. Hydroxyanthraquinones were the predominant antioxidant phenolic constituents in the roots of R. cordifolia, and tannins and gallic acid were the predominant antioxidant phenolic constituents in the roots of R. officinale. The structure-radical scavenging activity relationships of the tested hydroxyanthraquinones were systematically demonstrated as follows: Hydroxy groups on one benzene ring of the anthraquinone structure were essential for hydroxyanthraquinones to show activity, the ortho-dihydroxy structure in the hydroxyanthraquinone molecules could greatly enhance their radical scavenging effect, and glycosylation of the hydroxyanthraquinones reduced activity.

Authors+Show Affiliations

Departments of Botany and Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong,No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15612771

Citation

Cai, Yizhong, et al. "Antioxidant Phenolic Constituents in Roots of Rheum Officinale and Rubia Cordifolia: Structure-radical Scavenging Activity Relationships." Journal of Agricultural and Food Chemistry, vol. 52, no. 26, 2004, pp. 7884-90.
Cai Y, Sun M, Xing J, et al. Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. J Agric Food Chem. 2004;52(26):7884-90.
Cai, Y., Sun, M., Xing, J., & Corke, H. (2004). Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. Journal of Agricultural and Food Chemistry, 52(26), 7884-90.
Cai Y, et al. Antioxidant Phenolic Constituents in Roots of Rheum Officinale and Rubia Cordifolia: Structure-radical Scavenging Activity Relationships. J Agric Food Chem. 2004 Dec 29;52(26):7884-90. PubMed PMID: 15612771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. AU - Cai,Yizhong, AU - Sun,Mei, AU - Xing,Jie, AU - Corke,Harold, PY - 2004/12/23/pubmed PY - 2005/1/27/medline PY - 2004/12/23/entrez SP - 7884 EP - 90 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 52 IS - 26 N2 - The phenolic constituents in the roots of Rheum officinale and Rubia cordifolia were identified with the aid of high-performance liquid chromatography and liquid chromatography-mass spectrometry and by comparison with authentic standards. A total of 17 hydroxyanthraquinones, gallic acid, and tannins were separated, and 14 of them were identified, being the main phenolic constituents present. Their antioxidant activity (Trolox equivalent antioxidant capacity) was evaluated using the improved 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt method. Hydroxyanthraquinones were the predominant antioxidant phenolic constituents in the roots of R. cordifolia, and tannins and gallic acid were the predominant antioxidant phenolic constituents in the roots of R. officinale. The structure-radical scavenging activity relationships of the tested hydroxyanthraquinones were systematically demonstrated as follows: Hydroxy groups on one benzene ring of the anthraquinone structure were essential for hydroxyanthraquinones to show activity, the ortho-dihydroxy structure in the hydroxyanthraquinone molecules could greatly enhance their radical scavenging effect, and glycosylation of the hydroxyanthraquinones reduced activity. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15612771/Antioxidant_phenolic_constituents_in_roots_of_Rheum_officinale_and_Rubia_cordifolia:_structure_radical_scavenging_activity_relationships_ L2 - https://doi.org/10.1021/jf0489116 DB - PRIME DP - Unbound Medicine ER -