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Parent-reported outcomes for treatment of acute otitis media with cefdinir or amoxicillin/clavulanate oral suspensions.
Paediatr Drugs 2004; 6(6):387-93PD

Abstract

OBJECTIVE

To compare parent-reported outcomes (satisfaction, tolerability, compliance, and work/daycare missed) for children (aged 6 months to 6 years) receiving either cefdinir or amoxicillin/clavulanate for acute otitis media.

METHOD

In a phase IV, investigator-blinded, parallel-group, randomized, multicenter study, parents or legal guardians were asked to complete the Otitis Parent Questionnaire (OPQ) 12-14 days after the first dose of cefdinir or amoxicillin/clavulanate oral suspensions. Responses in each of the outcome domains were analyzed using non-parametric statistical analysis.

RESULTS

Of 367 parents/guardians who completed the questionnaire, better ease of use (p = 0.009) and taste (p < 0.0001) were associated with cefdinir versus amoxicillin/clavulanate treatment, and children were significantly more likely to experience vomiting with amoxicillin/clavulanate (16% vs 8%; p = 0.016). Parents also reported that their children were much more likely to take all of their medication if receiving cefdinir (68% vs 53% for amoxicillin/clavulanate; p = 0.005). There were no statistically significant differences between groups in work/daycare missed.

CONCLUSION

Based on parents' assessment using the OPQ, cefdinir was easier to administer and tasted better than amoxicillin/clavulanate. Children who received cefdinir also experienced less vomiting and had greater compliance than children who received amoxicillin/clavulanate.

Authors+Show Affiliations

Health Economics and Outcomes Research, Abbott Laboratories, Abbott Park, Illinois 60064-6124, USA. Mary.Cifaldi@abbott.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15612839

Citation

Cifaldi, Mary A., et al. "Parent-reported Outcomes for Treatment of Acute Otitis Media With Cefdinir or Amoxicillin/clavulanate Oral Suspensions." Paediatric Drugs, vol. 6, no. 6, 2004, pp. 387-93.
Cifaldi MA, Paris MM, Devcich KJ, et al. Parent-reported outcomes for treatment of acute otitis media with cefdinir or amoxicillin/clavulanate oral suspensions. Paediatr Drugs. 2004;6(6):387-93.
Cifaldi, M. A., Paris, M. M., Devcich, K. J., & Bukofzer, S. (2004). Parent-reported outcomes for treatment of acute otitis media with cefdinir or amoxicillin/clavulanate oral suspensions. Paediatric Drugs, 6(6), pp. 387-93.
Cifaldi MA, et al. Parent-reported Outcomes for Treatment of Acute Otitis Media With Cefdinir or Amoxicillin/clavulanate Oral Suspensions. Paediatr Drugs. 2004;6(6):387-93. PubMed PMID: 15612839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parent-reported outcomes for treatment of acute otitis media with cefdinir or amoxicillin/clavulanate oral suspensions. AU - Cifaldi,Mary A, AU - Paris,Maria M, AU - Devcich,Karen J, AU - Bukofzer,Stanley, PY - 2004/12/23/pubmed PY - 2005/7/29/medline PY - 2004/12/23/entrez SP - 387 EP - 93 JF - Paediatric drugs JO - Paediatr Drugs VL - 6 IS - 6 N2 - OBJECTIVE: To compare parent-reported outcomes (satisfaction, tolerability, compliance, and work/daycare missed) for children (aged 6 months to 6 years) receiving either cefdinir or amoxicillin/clavulanate for acute otitis media. METHOD: In a phase IV, investigator-blinded, parallel-group, randomized, multicenter study, parents or legal guardians were asked to complete the Otitis Parent Questionnaire (OPQ) 12-14 days after the first dose of cefdinir or amoxicillin/clavulanate oral suspensions. Responses in each of the outcome domains were analyzed using non-parametric statistical analysis. RESULTS: Of 367 parents/guardians who completed the questionnaire, better ease of use (p = 0.009) and taste (p < 0.0001) were associated with cefdinir versus amoxicillin/clavulanate treatment, and children were significantly more likely to experience vomiting with amoxicillin/clavulanate (16% vs 8%; p = 0.016). Parents also reported that their children were much more likely to take all of their medication if receiving cefdinir (68% vs 53% for amoxicillin/clavulanate; p = 0.005). There were no statistically significant differences between groups in work/daycare missed. CONCLUSION: Based on parents' assessment using the OPQ, cefdinir was easier to administer and tasted better than amoxicillin/clavulanate. Children who received cefdinir also experienced less vomiting and had greater compliance than children who received amoxicillin/clavulanate. SN - 1174-5878 UR - https://www.unboundmedicine.com/medline/citation/15612839/Parent_reported_outcomes_for_treatment_of_acute_otitis_media_with_cefdinir_or_amoxicillin/clavulanate_oral_suspensions_ L2 - https://dx.doi.org/10.2165/00148581-200406060-00006 DB - PRIME DP - Unbound Medicine ER -