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High risk of recurrent venous thromboembolism in men.
J Thromb Haemost 2004; 2(12):2152-5JT

Abstract

BACKGROUND

We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE).

METHODS

The Cambridge Venous Thromboembolism Study (CVTE) is a single-center study of a cohort of unselected patients with a first episode of objectively proven VTE.

RESULTS

Recurrence rates were significantly higher in men compared with women [log rank chi2=11.82; hazard ratio (HR) 2.66; 95% confidence interval (CI) 1.49, 4,77; P=0.0006]. The cumulative recurrence rate at 2 years was 19.2% in men and 7.7% in women. There was no evidence of a difference in recurrence between men with or without thrombophilia (log rank chi2=0.03; HR 1.08; 95% CI 0.49, 2.37; P=0.855). The high recurrence rate in men compared with women was still observed when only patients with idiopathic VTE were analyzed (log rank chi2=4.38; HR 2.31; 95% CI 1.027, 5.20; P=0.0363). The recurrence risk was highest in men with a first idiopathic event at 25.7% compared with 11.7% for women in the same category.

CONCLUSION

The risk of recurrent VTE is higher in men than in women.

Authors+Show Affiliations

Addenbrooke's NHS Trust, Cambridge CB2 2QQ, UK. tpb20@cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15613020

Citation

Baglin, T, et al. "High Risk of Recurrent Venous Thromboembolism in Men." Journal of Thrombosis and Haemostasis : JTH, vol. 2, no. 12, 2004, pp. 2152-5.
Baglin T, Luddington R, Brown K, et al. High risk of recurrent venous thromboembolism in men. J Thromb Haemost. 2004;2(12):2152-5.
Baglin, T., Luddington, R., Brown, K., & Baglin, C. (2004). High risk of recurrent venous thromboembolism in men. Journal of Thrombosis and Haemostasis : JTH, 2(12), pp. 2152-5.
Baglin T, et al. High Risk of Recurrent Venous Thromboembolism in Men. J Thromb Haemost. 2004;2(12):2152-5. PubMed PMID: 15613020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High risk of recurrent venous thromboembolism in men. AU - Baglin,T, AU - Luddington,R, AU - Brown,K, AU - Baglin,C, PY - 2004/12/23/pubmed PY - 2005/5/13/medline PY - 2004/12/23/entrez SP - 2152 EP - 5 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 2 IS - 12 N2 - BACKGROUND: We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE). METHODS: The Cambridge Venous Thromboembolism Study (CVTE) is a single-center study of a cohort of unselected patients with a first episode of objectively proven VTE. RESULTS: Recurrence rates were significantly higher in men compared with women [log rank chi2=11.82; hazard ratio (HR) 2.66; 95% confidence interval (CI) 1.49, 4,77; P=0.0006]. The cumulative recurrence rate at 2 years was 19.2% in men and 7.7% in women. There was no evidence of a difference in recurrence between men with or without thrombophilia (log rank chi2=0.03; HR 1.08; 95% CI 0.49, 2.37; P=0.855). The high recurrence rate in men compared with women was still observed when only patients with idiopathic VTE were analyzed (log rank chi2=4.38; HR 2.31; 95% CI 1.027, 5.20; P=0.0363). The recurrence risk was highest in men with a first idiopathic event at 25.7% compared with 11.7% for women in the same category. CONCLUSION: The risk of recurrent VTE is higher in men than in women. SN - 1538-7933 UR - https://www.unboundmedicine.com/medline/citation/15613020/High_risk_of_recurrent_venous_thromboembolism_in_men_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1538-7933&date=2004&volume=2&issue=12&spage=2152 DB - PRIME DP - Unbound Medicine ER -