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Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease.
Can J Cardiol 2004; 20(14):1433-8CJ

Abstract

BACKGROUND

Inflammation plays an important role in atherosclerosis. Markers of low-grade chronic inflammation, such as C-reactive protein (CRP) and soluble cell adhesion molecules (sCAMs), have been associated with coronary artery disease (CAD).

OBJECTIVE

To evaluate the significance of inflammatory markers as novel risk factors for CAD in the Chinese population.

METHODS

High-sensitivity CRP (hs-CRP); sCAMs, including vascular cell adhesion molecule-1 (sVCAM-1), intercellular cell adhesion molecule-1 (sICAM-1), P-selectin (sP-selectin) and E-selectin (sE-selectin); and white blood cell (WBC) count were measured in 170 angiographically defined CAD patients (70% or greater stenosis affecting at least one vessel) and 177 healthy control subjects in the Chinese population in Singapore.

RESULTS

The levels of hs-CRP, sVCAM-1 and sP-selectin, and the WBC count were higher in CAD patients than in control subjects (P<0.001, P<0.05, P<0.05 and P<0.001, respectively). There were no significant differences in the levels of sICAM-1 and sE-selectin between the two groups. Patients with unstable angina or myocardial infarction had higher levels of hs-CRP, and higher WBC and monocyte counts than those with stable angina or atypical chest pain (all P<0.05). The level of sP-selectin in patients with multivessel disease was higher than in those with single-vessel disease (P<0.05). Overall, the levels of hs-CRP and sCAMs showed a significant correlation with the lipid profile and the WBC count.

CONCLUSIONS

The present study suggests that inflammatory markers, including hs-CRP and WBC count, together with sP-selectin and sVCAM-1, could serve as markers of atherogenesis in Chinese patients with CAD, with potential diagnostic and therapeutic implications.

Authors+Show Affiliations

Johns Hopkins Singapore-National Heart Centre Vascular Biology Program, National Heart Centre of Singapore, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15614337

Citation

Fang, Lu, et al. "Markers of Low-grade Inflammation and Soluble Cell Adhesion Molecules in Chinese Patients With Coronary Artery Disease." The Canadian Journal of Cardiology, vol. 20, no. 14, 2004, pp. 1433-8.
Fang L, Wei H, Mak KH, et al. Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease. Can J Cardiol. 2004;20(14):1433-8.
Fang, L., Wei, H., Mak, K. H., Xiong, Z., Song, J., Wang, D., ... Chatterjee, S. (2004). Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease. The Canadian Journal of Cardiology, 20(14), pp. 1433-8.
Fang L, et al. Markers of Low-grade Inflammation and Soluble Cell Adhesion Molecules in Chinese Patients With Coronary Artery Disease. Can J Cardiol. 2004;20(14):1433-8. PubMed PMID: 15614337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease. AU - Fang,Lu, AU - Wei,Heming, AU - Mak,Koon Hou, AU - Xiong,Zhuowei, AU - Song,Jie, AU - Wang,Dong, AU - Lim,Yean Leng, AU - Chatterjee,Subroto, PY - 2004/12/23/pubmed PY - 2005/1/28/medline PY - 2004/12/23/entrez SP - 1433 EP - 8 JF - The Canadian journal of cardiology JO - Can J Cardiol VL - 20 IS - 14 N2 - BACKGROUND: Inflammation plays an important role in atherosclerosis. Markers of low-grade chronic inflammation, such as C-reactive protein (CRP) and soluble cell adhesion molecules (sCAMs), have been associated with coronary artery disease (CAD). OBJECTIVE: To evaluate the significance of inflammatory markers as novel risk factors for CAD in the Chinese population. METHODS: High-sensitivity CRP (hs-CRP); sCAMs, including vascular cell adhesion molecule-1 (sVCAM-1), intercellular cell adhesion molecule-1 (sICAM-1), P-selectin (sP-selectin) and E-selectin (sE-selectin); and white blood cell (WBC) count were measured in 170 angiographically defined CAD patients (70% or greater stenosis affecting at least one vessel) and 177 healthy control subjects in the Chinese population in Singapore. RESULTS: The levels of hs-CRP, sVCAM-1 and sP-selectin, and the WBC count were higher in CAD patients than in control subjects (P<0.001, P<0.05, P<0.05 and P<0.001, respectively). There were no significant differences in the levels of sICAM-1 and sE-selectin between the two groups. Patients with unstable angina or myocardial infarction had higher levels of hs-CRP, and higher WBC and monocyte counts than those with stable angina or atypical chest pain (all P<0.05). The level of sP-selectin in patients with multivessel disease was higher than in those with single-vessel disease (P<0.05). Overall, the levels of hs-CRP and sCAMs showed a significant correlation with the lipid profile and the WBC count. CONCLUSIONS: The present study suggests that inflammatory markers, including hs-CRP and WBC count, together with sP-selectin and sVCAM-1, could serve as markers of atherogenesis in Chinese patients with CAD, with potential diagnostic and therapeutic implications. SN - 0828-282X UR - https://www.unboundmedicine.com/medline/citation/15614337/Markers_of_low_grade_inflammation_and_soluble_cell_adhesion_molecules_in_Chinese_patients_with_coronary_artery_disease_ L2 - https://medlineplus.gov/coronaryarterydisease.html DB - PRIME DP - Unbound Medicine ER -