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Avian influenza viruses and their implication for human health.

Abstract

Widespread outbreaks of avian influenza in domestic fowl throughout eastern Asia have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza pandemic. Simultaneous infection of humans (or swine) by avian influenza viruses in the presence of human influenza viruses could theoretically generate novel influenza viruses with pandemic potential as a result of reassortment of genome subunits between avian and mammalian influenza viruses. These hybrid viruses would have the potential to express surface antigens from avian viruses to which the human population has no preexisting immunity. This article reviews current knowledge of the routes of transmission of avian influenza A viruses to humans, places the risk of appearance of a new pandemic influenza virus in perspective, and describes the recently observed epidemiology and clinical syndromes of avian influenza in humans.

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  • Publisher Full Text

    • Grapherence [↓9]

    Authors+Show Affiliations

    Kaye D
    ,

    Drexel University, College of Medicine, Philadelphia, PA, USA. donjank@aol.com

    Pringle CR

    Source

    MeSH

    Animals
    Birds
    Delivery of Health Care
    Disease Outbreaks
    Humans
    Influenza A virus
    Influenza in Birds
    Influenza, Human
    Reassortant Viruses

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15614699

    Citation

    Kaye, Donald, and Craig R. Pringle. "Avian Influenza Viruses and Their Implication for Human Health." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 40, no. 1, 2005, pp. 108-12.
    Kaye D, Pringle CR. Avian influenza viruses and their implication for human health. Clin Infect Dis. 2005;40(1):108-12.
    Kaye, D., & Pringle, C. R. (2005). Avian influenza viruses and their implication for human health. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 40(1), pp. 108-12.
    Kaye D, Pringle CR. Avian Influenza Viruses and Their Implication for Human Health. Clin Infect Dis. 2005 Jan 1;40(1):108-12. PubMed PMID: 15614699.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Avian influenza viruses and their implication for human health. AU - Kaye,Donald, AU - Pringle,Craig R, Y1 - 2004/12/07/ PY - 2004/10/05/received PY - 2004/11/04/accepted PY - 2004/12/23/pubmed PY - 2005/10/18/medline PY - 2004/12/23/entrez SP - 108 EP - 12 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 40 IS - 1 N2 - Widespread outbreaks of avian influenza in domestic fowl throughout eastern Asia have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza pandemic. Simultaneous infection of humans (or swine) by avian influenza viruses in the presence of human influenza viruses could theoretically generate novel influenza viruses with pandemic potential as a result of reassortment of genome subunits between avian and mammalian influenza viruses. These hybrid viruses would have the potential to express surface antigens from avian viruses to which the human population has no preexisting immunity. This article reviews current knowledge of the routes of transmission of avian influenza A viruses to humans, places the risk of appearance of a new pandemic influenza virus in perspective, and describes the recently observed epidemiology and clinical syndromes of avian influenza in humans. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15614699/Avian_influenza_viruses_and_their_implication_for_human_health_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/427236 DB - PRIME DP - Unbound Medicine ER -