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Avian influenza viruses and their implication for human health.
Clin Infect Dis. 2005 Jan 01; 40(1):108-12.CI

Abstract

Widespread outbreaks of avian influenza in domestic fowl throughout eastern Asia have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza pandemic. Simultaneous infection of humans (or swine) by avian influenza viruses in the presence of human influenza viruses could theoretically generate novel influenza viruses with pandemic potential as a result of reassortment of genome subunits between avian and mammalian influenza viruses. These hybrid viruses would have the potential to express surface antigens from avian viruses to which the human population has no preexisting immunity. This article reviews current knowledge of the routes of transmission of avian influenza A viruses to humans, places the risk of appearance of a new pandemic influenza virus in perspective, and describes the recently observed epidemiology and clinical syndromes of avian influenza in humans.

Authors+Show Affiliations

Kaye D
Drexel University, College of Medicine, Philadelphia, PA, USA. donjank@aol.com
Pringle CR
No affiliation info available

MeSH

AnimalsBirdsDelivery of Health CareDisease OutbreaksHumansInfluenza A virusInfluenza in BirdsInfluenza, HumanReassortant Viruses

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15614699

Citation

Kaye, Donald, and Craig R. Pringle. "Avian Influenza Viruses and Their Implication for Human Health." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 40, no. 1, 2005, pp. 108-12.
Kaye D, Pringle CR. Avian influenza viruses and their implication for human health. Clin Infect Dis. 2005;40(1):108-12.
Kaye, D., & Pringle, C. R. (2005). Avian influenza viruses and their implication for human health. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 40(1), 108-12.
Kaye D, Pringle CR. Avian Influenza Viruses and Their Implication for Human Health. Clin Infect Dis. 2005 Jan 1;40(1):108-12. PubMed PMID: 15614699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Avian influenza viruses and their implication for human health. AU - Kaye,Donald, AU - Pringle,Craig R, Y1 - 2004/12/07/ PY - 2004/10/05/received PY - 2004/11/04/accepted PY - 2004/12/23/pubmed PY - 2005/10/18/medline PY - 2004/12/23/entrez SP - 108 EP - 12 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 40 IS - 1 N2 - Widespread outbreaks of avian influenza in domestic fowl throughout eastern Asia have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza pandemic. Simultaneous infection of humans (or swine) by avian influenza viruses in the presence of human influenza viruses could theoretically generate novel influenza viruses with pandemic potential as a result of reassortment of genome subunits between avian and mammalian influenza viruses. These hybrid viruses would have the potential to express surface antigens from avian viruses to which the human population has no preexisting immunity. This article reviews current knowledge of the routes of transmission of avian influenza A viruses to humans, places the risk of appearance of a new pandemic influenza virus in perspective, and describes the recently observed epidemiology and clinical syndromes of avian influenza in humans. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15614699/Avian_influenza_viruses_and_their_implication_for_human_health_ DB - PRIME DP - Unbound Medicine ER -