Tags

Type your tag names separated by a space and hit enter

Anticarcinogenic properties of garlic: a review.

Abstract

Garlic is a popular spice added to several edible preparations and is a remedy for a variety of ailments. Epidemeological as well as laboratory studies have shown that garlic consumption reduces certain cancer incidences in the stomach, colon, mammary, cervical, etc. This article focuses on the general chemistry, metabolism, anticarcinogenic properties, mechanism of action behind the anticarcinogenic effects, functional foods based on garlic; and future areas of research. Garlic has been shown to metabolized into N-aceryl-S-allyl cysteine, allyl mercaptan, diallyl disulfide, diallyl sulfide, diallyl sulfoxide, diallyl sulfone, and allyl methyl sulfide. Garlic has been thought to bring about its anticarcinogenic effect through a number of mechanisms, such as the scavenging of radicals, increasing gluathione levels, increasing the activities of enzymes such as glutathione S-transferase, catalase, inhibition of cytochrome p4502E1, DNA repair mechanisms, prevention of chromosomal damage etc. Future research should standardize the dosage of garlic and type, ie., whether it should be taken fresh, cooked, or aged. The formulation of odorless functional foods with the retention of anticarcinogenic activity should be further studied.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Biochemistry and Nutrition, Defense Food Research Laboratory, Siddarthanagar, Mysore, India.

    ,

    Source

    MeSH

    Animals
    Anticarcinogenic Agents
    Antioxidants
    Diet
    Garlic
    Humans
    Immunity
    Neoplasms

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15615431

    Citation

    Khanum, Farhath, et al. "Anticarcinogenic Properties of Garlic: a Review." Critical Reviews in Food Science and Nutrition, vol. 44, no. 6, 2004, pp. 479-88.
    Khanum F, Anilakumar KR, Viswanathan KR. Anticarcinogenic properties of garlic: a review. Crit Rev Food Sci Nutr. 2004;44(6):479-88.
    Khanum, F., Anilakumar, K. R., & Viswanathan, K. R. (2004). Anticarcinogenic properties of garlic: a review. Critical Reviews in Food Science and Nutrition, 44(6), pp. 479-88.
    Khanum F, Anilakumar KR, Viswanathan KR. Anticarcinogenic Properties of Garlic: a Review. Crit Rev Food Sci Nutr. 2004;44(6):479-88. PubMed PMID: 15615431.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anticarcinogenic properties of garlic: a review. AU - Khanum,Farhath, AU - Anilakumar,K R, AU - Viswanathan,K R, PY - 2004/12/24/pubmed PY - 2005/3/4/medline PY - 2004/12/24/entrez SP - 479 EP - 88 JF - Critical reviews in food science and nutrition JO - Crit Rev Food Sci Nutr VL - 44 IS - 6 N2 - Garlic is a popular spice added to several edible preparations and is a remedy for a variety of ailments. Epidemeological as well as laboratory studies have shown that garlic consumption reduces certain cancer incidences in the stomach, colon, mammary, cervical, etc. This article focuses on the general chemistry, metabolism, anticarcinogenic properties, mechanism of action behind the anticarcinogenic effects, functional foods based on garlic; and future areas of research. Garlic has been shown to metabolized into N-aceryl-S-allyl cysteine, allyl mercaptan, diallyl disulfide, diallyl sulfide, diallyl sulfoxide, diallyl sulfone, and allyl methyl sulfide. Garlic has been thought to bring about its anticarcinogenic effect through a number of mechanisms, such as the scavenging of radicals, increasing gluathione levels, increasing the activities of enzymes such as glutathione S-transferase, catalase, inhibition of cytochrome p4502E1, DNA repair mechanisms, prevention of chromosomal damage etc. Future research should standardize the dosage of garlic and type, ie., whether it should be taken fresh, cooked, or aged. The formulation of odorless functional foods with the retention of anticarcinogenic activity should be further studied. SN - 1040-8398 UR - https://www.unboundmedicine.com/medline/citation/15615431/Anticarcinogenic_properties_of_garlic:_a_review_ L2 - http://www.tandfonline.com/doi/full/10.1080/10408690490886700 DB - PRIME DP - Unbound Medicine ER -