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Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study.

Abstract

Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, P.O. Box 1627, Kuopio, Finland.

    , , , , , , , , , , , , , , , , , , , , ,

    Source

    Diabetes 54:1 2005 Jan pg 158-65

    MeSH

    Diabetes Mellitus, Type 2
    Energy Intake
    Exercise
    Female
    Finland
    Glucose Tolerance Test
    Humans
    Leisure Activities
    Life Style
    Male
    Middle Aged
    Physical Fitness
    Risk Factors
    Walking
    Weight Loss

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15616024

    Citation

    Laaksonen, David E., et al. "Physical Activity in the Prevention of Type 2 Diabetes: the Finnish Diabetes Prevention Study." Diabetes, vol. 54, no. 1, 2005, pp. 158-65.
    Laaksonen DE, Lindström J, Lakka TA, et al. Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes. 2005;54(1):158-65.
    Laaksonen, D. E., Lindström, J., Lakka, T. A., Eriksson, J. G., Niskanen, L., Wikström, K., ... Uusitupa, M. (2005). Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes, 54(1), pp. 158-65.
    Laaksonen DE, et al. Physical Activity in the Prevention of Type 2 Diabetes: the Finnish Diabetes Prevention Study. Diabetes. 2005;54(1):158-65. PubMed PMID: 15616024.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. AU - Laaksonen,David E, AU - Lindström,Jaana, AU - Lakka,Timo A, AU - Eriksson,Johan G, AU - Niskanen,Leo, AU - Wikström,Katja, AU - Aunola,Sirkka, AU - Keinänen-Kiukaanniemi,Sirkka, AU - Laakso,Mauri, AU - Valle,Timo T, AU - Ilanne-Parikka,Pirjo, AU - Louheranta,Anne, AU - Hämäläinen,Helena, AU - Rastas,Merja, AU - Salminen,Virpi, AU - Cepaitis,Zygimantas, AU - Hakumäki,Martti, AU - Kaikkonen,Hannu, AU - Härkönen,Pirjo, AU - Sundvall,Jouko, AU - Tuomilehto,Jaakko, AU - Uusitupa,Matti, AU - ,, PY - 2004/12/24/pubmed PY - 2005/4/15/medline PY - 2004/12/24/entrez SP - 158 EP - 65 JF - Diabetes JO - Diabetes VL - 54 IS - 1 N2 - Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/15616024/full_citation L2 - http://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=15616024 DB - PRIME DP - Unbound Medicine ER -