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Association of estrogen receptor-alpha gene polymorphisms with bone mineral density in postmenopausal Korean women.
J Bone Miner Metab 2005; 23(1):84-9JB

Abstract

We examined the potential associations between PvuII and XbaI polymorphisms in the first intron of the estrogen receptor alpha (ER-alpha) gene and bone mineral density (BMD) in a population-based study of 174 postmenopausal Korean women. BMD was measured at the lumbar spine (L2-L4), right femoral neck, right trochanter, and right Ward's triangle. ER-alpha gene polymorphisms were detected by PvuII and XbaI restriction endonuclease digestion of polymerase chain reaction products. Differences in BMD values between the ER-alpha genotypes were analyzed in a general linear model, with adjustments for age, height, weight, and smoking status. The following genotype frequencies were noted: PP, 14.9%; Pp, 46.0%; pp, 39.1%; XX, 3.5%; Xx, 29.3%; and xx, 67.2%. Both the femoral neck and Ward's triangle BMD values in women with the Pp genotype were significantly (P < 0.05) higher than those in women with the pp genotype. No significant effect of the XbaI genotype on BMD was found at any site. Carriers of the pX haplotype were more likely to have lower BMD values at the trochanter than noncarriers, after adjustment for potentially confounding factors. Women with the pp genotype had more previous hip or spine fractures than those with other genotypes (P = 0.05). These results suggest that the PvuII polymorphism and the ER-alpha haplotype may be associated with the BMD at several femur sites in postmenopausal Korean women.

Authors+Show Affiliations

Department of Preventive Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15616899

Citation

Nam, Hae-Sung, et al. "Association of Estrogen Receptor-alpha Gene Polymorphisms With Bone Mineral Density in Postmenopausal Korean Women." Journal of Bone and Mineral Metabolism, vol. 23, no. 1, 2005, pp. 84-9.
Nam HS, Shin MH, Kweon SS, et al. Association of estrogen receptor-alpha gene polymorphisms with bone mineral density in postmenopausal Korean women. J Bone Miner Metab. 2005;23(1):84-9.
Nam, H. S., Shin, M. H., Kweon, S. S., Park, K. S., Sohn, S. J., Rhee, J. A., ... Son, M. H. (2005). Association of estrogen receptor-alpha gene polymorphisms with bone mineral density in postmenopausal Korean women. Journal of Bone and Mineral Metabolism, 23(1), pp. 84-9.
Nam HS, et al. Association of Estrogen Receptor-alpha Gene Polymorphisms With Bone Mineral Density in Postmenopausal Korean Women. J Bone Miner Metab. 2005;23(1):84-9. PubMed PMID: 15616899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of estrogen receptor-alpha gene polymorphisms with bone mineral density in postmenopausal Korean women. AU - Nam,Hae-Sung, AU - Shin,Min-Ho, AU - Kweon,Sun-Seog, AU - Park,Kyeong-Soo, AU - Sohn,Seok-Jun, AU - Rhee,Jung-Ae, AU - Choi,Jin-Su, AU - Son,Myung-Ho, PY - 2004/01/16/received PY - 2004/05/19/accepted PY - 2004/12/24/pubmed PY - 2005/5/5/medline PY - 2004/12/24/entrez SP - 84 EP - 9 JF - Journal of bone and mineral metabolism JO - J. Bone Miner. Metab. VL - 23 IS - 1 N2 - We examined the potential associations between PvuII and XbaI polymorphisms in the first intron of the estrogen receptor alpha (ER-alpha) gene and bone mineral density (BMD) in a population-based study of 174 postmenopausal Korean women. BMD was measured at the lumbar spine (L2-L4), right femoral neck, right trochanter, and right Ward's triangle. ER-alpha gene polymorphisms were detected by PvuII and XbaI restriction endonuclease digestion of polymerase chain reaction products. Differences in BMD values between the ER-alpha genotypes were analyzed in a general linear model, with adjustments for age, height, weight, and smoking status. The following genotype frequencies were noted: PP, 14.9%; Pp, 46.0%; pp, 39.1%; XX, 3.5%; Xx, 29.3%; and xx, 67.2%. Both the femoral neck and Ward's triangle BMD values in women with the Pp genotype were significantly (P < 0.05) higher than those in women with the pp genotype. No significant effect of the XbaI genotype on BMD was found at any site. Carriers of the pX haplotype were more likely to have lower BMD values at the trochanter than noncarriers, after adjustment for potentially confounding factors. Women with the pp genotype had more previous hip or spine fractures than those with other genotypes (P = 0.05). These results suggest that the PvuII polymorphism and the ER-alpha haplotype may be associated with the BMD at several femur sites in postmenopausal Korean women. SN - 0914-8779 UR - https://www.unboundmedicine.com/medline/citation/15616899/Association_of_estrogen_receptor_alpha_gene_polymorphisms_with_bone_mineral_density_in_postmenopausal_Korean_women_ L2 - https://dx.doi.org/10.1007/s00774-004-0545-8 DB - PRIME DP - Unbound Medicine ER -