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Risk assessment in patients with unstable angina/non-ST-elevation myocardial infarction and normal N-terminal pro-brain natriuretic peptide levels by N-terminal pro-atrial natriuretic peptide.
Eur Heart J 2005; 26(3):250-6EH

Abstract

AIMS

To compare the accuracy of the N-terminal fragment of its pro-hormone (Nt-proBNP) and N-terminal pro-atrial natriuretic peptide (Nt-proANP) in the prediction of the 2 year mortality and to investigate whether additional measurement of Nt-proANP to troponin I (TnI) could improve risk assessment in the subgroups of patients with unstable coronary artery disease (UCAD) and normal Nt-proBNP.

METHODS AND RESULTS

Plasma levels of the TnI, Nt-proANP, and Nt-proBNP were determined in 120 consecutive patients with UCAD without ST-segment elevations and normal left ventricular function. In multivariable logistic regression analysis, TnI and Nt-proBNP were independent predictors of mortality (P=0.01 and P=0.02, respectively). However, in the group of patients with normal Nt-proBNP levels, only Nt-proANP and TnI were independently associated with mortality (P=0.007 and P=0.03, respectively). Accordingly, patients with elevated Nt-proANP levels in this group of patients had significantly higher mortality rate than patients with normal Nt-proANP levels (P=0.003).

CONCLUSION

Our results suggest that determination of Nt-proANP might improve risk assessment in patients with UCAD, especially when Nt-proBNP is in the normal range.

Authors+Show Affiliations

Third Department of Medicine (Cardiology and Emergency Medicine), Wilhelminen Hospital Vienna, Montleartstrasse 37, A-1171 Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15618049

Citation

Jarai, Rudolf, et al. "Risk Assessment in Patients With Unstable angina/non-ST-elevation Myocardial Infarction and Normal N-terminal Pro-brain Natriuretic Peptide Levels By N-terminal Pro-atrial Natriuretic Peptide." European Heart Journal, vol. 26, no. 3, 2005, pp. 250-6.
Jarai R, Iordanova N, Jarai R, et al. Risk assessment in patients with unstable angina/non-ST-elevation myocardial infarction and normal N-terminal pro-brain natriuretic peptide levels by N-terminal pro-atrial natriuretic peptide. Eur Heart J. 2005;26(3):250-6.
Jarai, R., Iordanova, N., Jarai, R., Raffetseder, A., Woloszczuk, W., Gyöngyösi, M., ... Huber, K. (2005). Risk assessment in patients with unstable angina/non-ST-elevation myocardial infarction and normal N-terminal pro-brain natriuretic peptide levels by N-terminal pro-atrial natriuretic peptide. European Heart Journal, 26(3), pp. 250-6.
Jarai R, et al. Risk Assessment in Patients With Unstable angina/non-ST-elevation Myocardial Infarction and Normal N-terminal Pro-brain Natriuretic Peptide Levels By N-terminal Pro-atrial Natriuretic Peptide. Eur Heart J. 2005;26(3):250-6. PubMed PMID: 15618049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk assessment in patients with unstable angina/non-ST-elevation myocardial infarction and normal N-terminal pro-brain natriuretic peptide levels by N-terminal pro-atrial natriuretic peptide. AU - Jarai,Rudolf, AU - Iordanova,Nelly, AU - Jarai,Robert, AU - Raffetseder,Annamaria, AU - Woloszczuk,Wolfgang, AU - Gyöngyösi,Mariann, AU - Geyer,Georg, AU - Wojta,Johann, AU - Huber,Kurt, Y1 - 2004/12/20/ PY - 2004/12/25/pubmed PY - 2005/4/21/medline PY - 2004/12/25/entrez SP - 250 EP - 6 JF - European heart journal JO - Eur. Heart J. VL - 26 IS - 3 N2 - AIMS: To compare the accuracy of the N-terminal fragment of its pro-hormone (Nt-proBNP) and N-terminal pro-atrial natriuretic peptide (Nt-proANP) in the prediction of the 2 year mortality and to investigate whether additional measurement of Nt-proANP to troponin I (TnI) could improve risk assessment in the subgroups of patients with unstable coronary artery disease (UCAD) and normal Nt-proBNP. METHODS AND RESULTS: Plasma levels of the TnI, Nt-proANP, and Nt-proBNP were determined in 120 consecutive patients with UCAD without ST-segment elevations and normal left ventricular function. In multivariable logistic regression analysis, TnI and Nt-proBNP were independent predictors of mortality (P=0.01 and P=0.02, respectively). However, in the group of patients with normal Nt-proBNP levels, only Nt-proANP and TnI were independently associated with mortality (P=0.007 and P=0.03, respectively). Accordingly, patients with elevated Nt-proANP levels in this group of patients had significantly higher mortality rate than patients with normal Nt-proANP levels (P=0.003). CONCLUSION: Our results suggest that determination of Nt-proANP might improve risk assessment in patients with UCAD, especially when Nt-proBNP is in the normal range. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/15618049/Risk_assessment_in_patients_with_unstable_angina/non_ST_elevation_myocardial_infarction_and_normal_N_terminal_pro_brain_natriuretic_peptide_levels_by_N_terminal_pro_atrial_natriuretic_peptide_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehi038 DB - PRIME DP - Unbound Medicine ER -