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Biological activities of reverse signal transduction through CD137 ligand.
J Leukoc Biol. 2005 Mar; 77(3):281-6.JL

Abstract

CD137 is a member of the tumor necrosis factor receptor family and a potent regulator of T cell activities. Agonists of CD137 have been used widely and successfully to treat cancer in animal models, and recently, it has become evident that CD137 agonists can also be used to treat autoimmune disease. An aspect of the CD137 receptor/ligand system, which has been comparatively little-explored, is its ability of reverse signaling. Just as is CD137, the CD137 ligand is also expressed as a cell membrane protein, and it too can transduce signals into the cells on which it is expressed. This bidirectional signaling capacity allows the CD137 receptor/ligand system to mediate extensive cross-talk between immune cells and between immune and nonimmune cells. This review summarizes the known activities of the CD137 ligand on the different leukocyte subsets and on cancer cells and discusses their influence on the course of immune responses.

Authors+Show Affiliations

National University of Singapore, 2 Medical Drive, MD 9, Singapore 117597. phssh@nus.edu.sg

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15618293

Citation

Schwarz, Herbert. "Biological Activities of Reverse Signal Transduction Through CD137 Ligand." Journal of Leukocyte Biology, vol. 77, no. 3, 2005, pp. 281-6.
Schwarz H. Biological activities of reverse signal transduction through CD137 ligand. J Leukoc Biol. 2005;77(3):281-6.
Schwarz, H. (2005). Biological activities of reverse signal transduction through CD137 ligand. Journal of Leukocyte Biology, 77(3), 281-6.
Schwarz H. Biological Activities of Reverse Signal Transduction Through CD137 Ligand. J Leukoc Biol. 2005;77(3):281-6. PubMed PMID: 15618293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biological activities of reverse signal transduction through CD137 ligand. A1 - Schwarz,Herbert, Y1 - 2004/12/23/ PY - 2004/12/25/pubmed PY - 2005/4/19/medline PY - 2004/12/25/entrez SP - 281 EP - 6 JF - Journal of leukocyte biology JO - J Leukoc Biol VL - 77 IS - 3 N2 - CD137 is a member of the tumor necrosis factor receptor family and a potent regulator of T cell activities. Agonists of CD137 have been used widely and successfully to treat cancer in animal models, and recently, it has become evident that CD137 agonists can also be used to treat autoimmune disease. An aspect of the CD137 receptor/ligand system, which has been comparatively little-explored, is its ability of reverse signaling. Just as is CD137, the CD137 ligand is also expressed as a cell membrane protein, and it too can transduce signals into the cells on which it is expressed. This bidirectional signaling capacity allows the CD137 receptor/ligand system to mediate extensive cross-talk between immune cells and between immune and nonimmune cells. This review summarizes the known activities of the CD137 ligand on the different leukocyte subsets and on cancer cells and discusses their influence on the course of immune responses. SN - 0741-5400 UR - https://www.unboundmedicine.com/medline/citation/15618293/Biological_activities_of_reverse_signal_transduction_through_CD137_ligand_ L2 - https://doi.org/10.1189/jlb.0904558 DB - PRIME DP - Unbound Medicine ER -