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Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Québec Cardiovascular Study.
Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):553-9.AT

Abstract

OBJECTIVE

The objective of the present study was to investigate the association between large and small low-density lipoprotein (LDL) and long-term ischemic heart disease (IHD) risk in men of the Quebec Cardiovascular Study.

METHODS AND RESULTS

Cholesterol levels in the large and small LDL subfractions (termed LDL-C> or =260A and LDL-C<255A, respectively) were estimated from polyacrylamide gradient gel electrophoresis of whole plasma in the cohort of 2072 men of the population-based Quebec Cardiovascular Study. All men were free of IHD at the baseline examination and followed-up for a period of 13 years, during which 262 first IHD events (coronary death, nonfatal myocardial infarction, and unstable angina pectoris) were recorded. Our study confirmed the strong and independent association between LDL-C<255A levels as a proxy of the small dense LDL phenotype and the risk of IHD in men, particularly over the first 7 years of follow-up. However, elevated LDL-C> or =260A levels (third versus first tertile) were not associated with an increased risk of IHD over the 13-year follow-up (RR=0.76; P=0.07).

CONCLUSIONS

These results indicated that estimated cholesterol levels in the large LDL subfraction were not associated with an increased risk of IHD in men and that the cardiovascular risk attributable to variations in the LDL size phenotype was largely related to markers of a preferential accumulation of small dense LDL particles.

Authors+Show Affiliations

Institute on Nutraceuticals and Fonctionnal Foods, Laval University, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15618542

Citation

St-Pierre, Annie C., et al. "Low-density Lipoprotein Subfractions and the Long-term Risk of Ischemic Heart Disease in Men: 13-year Follow-up Data From the Québec Cardiovascular Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 3, 2005, pp. 553-9.
St-Pierre AC, Cantin B, Dagenais GR, et al. Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Québec Cardiovascular Study. Arterioscler Thromb Vasc Biol. 2005;25(3):553-9.
St-Pierre, A. C., Cantin, B., Dagenais, G. R., Mauriège, P., Bernard, P. M., Després, J. P., & Lamarche, B. (2005). Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Québec Cardiovascular Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(3), 553-9.
St-Pierre AC, et al. Low-density Lipoprotein Subfractions and the Long-term Risk of Ischemic Heart Disease in Men: 13-year Follow-up Data From the Québec Cardiovascular Study. Arterioscler Thromb Vasc Biol. 2005;25(3):553-9. PubMed PMID: 15618542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Québec Cardiovascular Study. AU - St-Pierre,Annie C, AU - Cantin,Bernard, AU - Dagenais,Gilles R, AU - Mauriège,Pascale, AU - Bernard,Paul-Marie, AU - Després,Jean-Pierre, AU - Lamarche,Benoît, Y1 - 2004/12/23/ PY - 2004/12/25/pubmed PY - 2005/11/9/medline PY - 2004/12/25/entrez SP - 553 EP - 9 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 25 IS - 3 N2 - OBJECTIVE: The objective of the present study was to investigate the association between large and small low-density lipoprotein (LDL) and long-term ischemic heart disease (IHD) risk in men of the Quebec Cardiovascular Study. METHODS AND RESULTS: Cholesterol levels in the large and small LDL subfractions (termed LDL-C> or =260A and LDL-C<255A, respectively) were estimated from polyacrylamide gradient gel electrophoresis of whole plasma in the cohort of 2072 men of the population-based Quebec Cardiovascular Study. All men were free of IHD at the baseline examination and followed-up for a period of 13 years, during which 262 first IHD events (coronary death, nonfatal myocardial infarction, and unstable angina pectoris) were recorded. Our study confirmed the strong and independent association between LDL-C<255A levels as a proxy of the small dense LDL phenotype and the risk of IHD in men, particularly over the first 7 years of follow-up. However, elevated LDL-C> or =260A levels (third versus first tertile) were not associated with an increased risk of IHD over the 13-year follow-up (RR=0.76; P=0.07). CONCLUSIONS: These results indicated that estimated cholesterol levels in the large LDL subfraction were not associated with an increased risk of IHD in men and that the cardiovascular risk attributable to variations in the LDL size phenotype was largely related to markers of a preferential accumulation of small dense LDL particles. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/15618542/Low_density_lipoprotein_subfractions_and_the_long_term_risk_of_ischemic_heart_disease_in_men:_13_year_follow_up_data_from_the_Québec_Cardiovascular_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000154144.73236.f4?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -