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Efficacy and safety of sildenafil citrate in men with erectile dysfunction and chronic heart failure.
Am J Cardiol. 2005 Jan 01; 95(1):36-42.AJ

Abstract

Chronic heart failure (CHF) is an increasingly common cardiovascular disorder. Many patients who have CHF report moderate to marked decreases in the frequency of sexual activity, and up to 75% of patients report erectile dysfunction (ED). There are few controlled clinical data on the efficacy and safety of sildenafil citrate in men who have ED and CHF; thus, we evaluated these parameters in patients who had stable CHF. This was a double-blind, placebo-controlled, flexible-dose study. Men who had ED and stable CHF were randomized to receive sildenafil or placebo for 12 weeks. Primary outcomes were questions 3 and 4 of the International Index of Erectile Function. Secondary outcomes included the 5 functional domains of the International Index of Erectile Function, 2 global efficacy assessment questions, intercourse success rate, the Erectile Dysfunction Inventory of Treatment Satisfaction, and the Life Satisfaction Checklist. By week 12, patients who received sildenafil (n = 60) showed significant improvements on questions 3 and 4 compared with patients who received placebo (n = 72; p <0.002). Larger percentages of patients who received sildenafil reported improved erections (74%) and improved intercourse (68%) compared with patients who received placebo (18% and 16%, respectively). Intercourse success rates were 53% among patients who received sildenafil and 20% among those who received placebo. Patients who received sildenafil were highly satisfied with treatment and their sexual life compared with patients who received placebo. Sixty percent of patients who received sildenafil and 48% of patients who received placebo developed adverse events, including transient headache, facial flushing, respiratory tract infection, and asthenia. The incidence of events related to cardiovascular effects was low. Sildenafil is an effective and well-tolerated management of ED in men who have mild to moderate CHF.

Authors+Show Affiliations

Department of Internal Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA. stuart.katz@yale.edu <stuart.katz@yale.edu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15619391

Citation

Katz, Stuart D., et al. "Efficacy and Safety of Sildenafil Citrate in Men With Erectile Dysfunction and Chronic Heart Failure." The American Journal of Cardiology, vol. 95, no. 1, 2005, pp. 36-42.
Katz SD, Parker JD, Glasser DB, et al. Efficacy and safety of sildenafil citrate in men with erectile dysfunction and chronic heart failure. Am J Cardiol. 2005;95(1):36-42.
Katz, S. D., Parker, J. D., Glasser, D. B., Bank, A. J., Sherman, N., Wang, H., & Sweeney, M. (2005). Efficacy and safety of sildenafil citrate in men with erectile dysfunction and chronic heart failure. The American Journal of Cardiology, 95(1), 36-42.
Katz SD, et al. Efficacy and Safety of Sildenafil Citrate in Men With Erectile Dysfunction and Chronic Heart Failure. Am J Cardiol. 2005 Jan 1;95(1):36-42. PubMed PMID: 15619391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of sildenafil citrate in men with erectile dysfunction and chronic heart failure. AU - Katz,Stuart D, AU - Parker,John D, AU - Glasser,Dale B, AU - Bank,Alan J, AU - Sherman,Nancy, AU - Wang,Hao, AU - Sweeney,Michael, PY - 2004/07/14/received PY - 2004/08/28/revised PY - 2004/08/26/accepted PY - 2004/12/28/pubmed PY - 2005/2/23/medline PY - 2004/12/28/entrez SP - 36 EP - 42 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 95 IS - 1 N2 - Chronic heart failure (CHF) is an increasingly common cardiovascular disorder. Many patients who have CHF report moderate to marked decreases in the frequency of sexual activity, and up to 75% of patients report erectile dysfunction (ED). There are few controlled clinical data on the efficacy and safety of sildenafil citrate in men who have ED and CHF; thus, we evaluated these parameters in patients who had stable CHF. This was a double-blind, placebo-controlled, flexible-dose study. Men who had ED and stable CHF were randomized to receive sildenafil or placebo for 12 weeks. Primary outcomes were questions 3 and 4 of the International Index of Erectile Function. Secondary outcomes included the 5 functional domains of the International Index of Erectile Function, 2 global efficacy assessment questions, intercourse success rate, the Erectile Dysfunction Inventory of Treatment Satisfaction, and the Life Satisfaction Checklist. By week 12, patients who received sildenafil (n = 60) showed significant improvements on questions 3 and 4 compared with patients who received placebo (n = 72; p <0.002). Larger percentages of patients who received sildenafil reported improved erections (74%) and improved intercourse (68%) compared with patients who received placebo (18% and 16%, respectively). Intercourse success rates were 53% among patients who received sildenafil and 20% among those who received placebo. Patients who received sildenafil were highly satisfied with treatment and their sexual life compared with patients who received placebo. Sixty percent of patients who received sildenafil and 48% of patients who received placebo developed adverse events, including transient headache, facial flushing, respiratory tract infection, and asthenia. The incidence of events related to cardiovascular effects was low. Sildenafil is an effective and well-tolerated management of ED in men who have mild to moderate CHF. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/15619391/Efficacy_and_safety_of_sildenafil_citrate_in_men_with_erectile_dysfunction_and_chronic_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(04)01444-4 DB - PRIME DP - Unbound Medicine ER -