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Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice.
Neurosci Lett. 2005 Jan 20; 373(3):237-42.NL

Abstract

The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI). There were no significant differences between gastrin knockout mice and their wildtype controls in any of these baseline parameters. The disruption of PPI by treatment with 5 mg/kg of amphetamine was absent in gastrin knockout mice. However, a higher dose of amphetamine disrupted PPI in both genotypes. Similarly, treatment with the dopamine receptor agonist, apomorphine, the N-methyl-D-aspartate receptor antagonist, MK-801, and the serotonin-1A receptor agonist, 8-hydroxy-di-propylaminotetralin (8-OH-DPAT) modulated PPI similarly in gastrin knockout mice and wildtype controls. These data suggest a role of gastrin in the brain in modulating dopamine release in areas involved in PPI.

Authors+Show Affiliations

van den Buuse M
Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Vic. 3052, Australia. mvandenbuuse@mhri.edu.au
van Driel IR
No affiliation info available
Samuelson LC
No affiliation info available
Pijnappel M
No affiliation info available
Martin S
No affiliation info available

MeSH

AmphetamineAnimalsDizocilpine MaleateFemaleGastrinsMaleMiceMice, Inbred BALB CMice, KnockoutReflex, Startle

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15619550

Citation

van den Buuse, Maarten, et al. "Reduced Effects of Amphetamine On Prepulse Inhibition of Startle in Gastrin-deficient Mice." Neuroscience Letters, vol. 373, no. 3, 2005, pp. 237-42.
van den Buuse M, van Driel IR, Samuelson LC, et al. Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice. Neurosci Lett. 2005;373(3):237-42.
van den Buuse, M., van Driel, I. R., Samuelson, L. C., Pijnappel, M., & Martin, S. (2005). Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice. Neuroscience Letters, 373(3), 237-42.
van den Buuse M, et al. Reduced Effects of Amphetamine On Prepulse Inhibition of Startle in Gastrin-deficient Mice. Neurosci Lett. 2005 Jan 20;373(3):237-42. PubMed PMID: 15619550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice. AU - van den Buuse,Maarten, AU - van Driel,Ian R, AU - Samuelson,Linda C, AU - Pijnappel,Meggie, AU - Martin,Sally, PY - 2004/08/31/received PY - 2004/09/27/revised PY - 2004/10/05/accepted PY - 2004/12/28/pubmed PY - 2005/3/2/medline PY - 2004/12/28/entrez SP - 237 EP - 42 JF - Neuroscience letters JO - Neurosci Lett VL - 373 IS - 3 N2 - The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI). There were no significant differences between gastrin knockout mice and their wildtype controls in any of these baseline parameters. The disruption of PPI by treatment with 5 mg/kg of amphetamine was absent in gastrin knockout mice. However, a higher dose of amphetamine disrupted PPI in both genotypes. Similarly, treatment with the dopamine receptor agonist, apomorphine, the N-methyl-D-aspartate receptor antagonist, MK-801, and the serotonin-1A receptor agonist, 8-hydroxy-di-propylaminotetralin (8-OH-DPAT) modulated PPI similarly in gastrin knockout mice and wildtype controls. These data suggest a role of gastrin in the brain in modulating dopamine release in areas involved in PPI. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15619550/Reduced_effects_of_amphetamine_on_prepulse_inhibition_of_startle_in_gastrin_deficient_mice_ DB - PRIME DP - Unbound Medicine ER -