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[Diagnosis of hepatitis E virus infection in sporadic acute hepatitis].

Abstract

The solid-phase enzyme immunoassay (EIA) was used for detecting anti-HEV immunoglobulin G (IgG) and M (IgM) by using a recombinant chimeric antigen (ORF3-2) from the open reading frame (ORF) 2 and 3 of hepatitis E virus gene. These sera were collected from the patients with sporadic acute viral hepatitis. The positive rate for anti-HEV IgG was 15.22% (7) among 46 patients with acute hepatitis, 5 of the 7 IgG positive sera were also positive (71.4%) for anti-HEV IgM. 91.8% (93) and 76.4% (78) were positive separately for anti-HEV IgG and IgM among 102 patients of suspected HEV infection (these patients were negative for anti-HAV, anti-HBV and anti-HCV), about 2/3 patients of HEV infection detected were simultaneously HEV-IgG and IgM positive. In control group of 98 normal persons, 4 (4.08%) were positive for anti-HEV IgG, but none were IgM positive. Paired sera of the patients in the acute phase and convalescent phase were detected, the titers of anti-HEV IgG with 4-16 fold decrease were seen in 6 cases and with 2-fold rise in 1 case.

Authors+Show Affiliations

Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15619831

Citation

Jiang, Y, et al. "[Diagnosis of Hepatitis E Virus Infection in Sporadic Acute Hepatitis]." Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, vol. 11, no. 2, 1997, pp. 177-80.
Jiang Y, Bi S, Li J, et al. [Diagnosis of hepatitis E virus infection in sporadic acute hepatitis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997;11(2):177-80.
Jiang, Y., Bi, S., Li, J., Lu, J., Liao, S., Zhao, H., Wang, P., Zhan, M., & Liu, C. (1997). [Diagnosis of hepatitis E virus infection in sporadic acute hepatitis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, 11(2), 177-80.
Jiang Y, et al. [Diagnosis of Hepatitis E Virus Infection in Sporadic Acute Hepatitis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997;11(2):177-80. PubMed PMID: 15619831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnosis of hepatitis E virus infection in sporadic acute hepatitis]. AU - Jiang,Y, AU - Bi,S, AU - Li,J, AU - Lu,J, AU - Liao,S, AU - Zhao,H, AU - Wang,P, AU - Zhan,M, AU - Liu,C, PY - 1997/6/1/pubmed PY - 2009/4/25/medline PY - 1997/6/1/entrez SP - 177 EP - 80 JF - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology JO - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi VL - 11 IS - 2 N2 - The solid-phase enzyme immunoassay (EIA) was used for detecting anti-HEV immunoglobulin G (IgG) and M (IgM) by using a recombinant chimeric antigen (ORF3-2) from the open reading frame (ORF) 2 and 3 of hepatitis E virus gene. These sera were collected from the patients with sporadic acute viral hepatitis. The positive rate for anti-HEV IgG was 15.22% (7) among 46 patients with acute hepatitis, 5 of the 7 IgG positive sera were also positive (71.4%) for anti-HEV IgM. 91.8% (93) and 76.4% (78) were positive separately for anti-HEV IgG and IgM among 102 patients of suspected HEV infection (these patients were negative for anti-HAV, anti-HBV and anti-HCV), about 2/3 patients of HEV infection detected were simultaneously HEV-IgG and IgM positive. In control group of 98 normal persons, 4 (4.08%) were positive for anti-HEV IgG, but none were IgM positive. Paired sera of the patients in the acute phase and convalescent phase were detected, the titers of anti-HEV IgG with 4-16 fold decrease were seen in 6 cases and with 2-fold rise in 1 case. SN - 1003-9279 UR - https://www.unboundmedicine.com/medline/citation/15619831/[Diagnosis_of_hepatitis_E_virus_infection_in_sporadic_acute_hepatitis]_ L2 - https://www.diseaseinfosearch.org/result/3334 DB - PRIME DP - Unbound Medicine ER -